SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rwf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)
4rwf ADRENOMEDULLIN
MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo
sapiens)
4 / 6 LEU A1109
ILE A1120
TYR B  52
VAL A1065
None
0.96A 1db1A-4rwfA:
undetectable
1db1A-4rwfA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo
sapiens)
4 / 6 VAL A  10
VAL A  52
ILE A  62
ASN A 269
None
0.91A 1e06A-4rwfA:
undetectable
1e06A-4rwfA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo
sapiens)
3 / 3 PHE A1111
TYR A2049
PRO A1112
None
1.17A 1mcnA-4rwfA:
undetectable
1mcnB-4rwfA:
undetectable
1mcnP-4rwfA:
undetectable
1mcnA-4rwfA:
16.70
1mcnB-4rwfA:
16.70
1mcnP-4rwfA:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo
sapiens)
3 / 3 ASP A2090
GLU A2047
ARG A1097
None
EDO  A2205 ( 3.2A)
None
0.79A 1wopA-4rwfA:
undetectable
1wopA-4rwfA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo
sapiens)
5 / 10 LEU A 194
LEU A 197
ILE A 163
GLU A 155
LEU A 153
None
None
None
MAL  A2201 (-3.7A)
None
1.24A 1wopA-4rwfA:
undetectable
1wopA-4rwfA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6001_0
(PANTOTHENATE KINASE)
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN
ADRENOMEDULLIN

(Escherichia
coli;
Homo
sapiens;
Homo
sapiens)
5 / 11 TYR B  52
ASP A1098
ARG A1097
ILE A2041
ARG A 356
None
1.30A 2f9wA-4rwfB:
undetectable
2f9wB-4rwfB:
undetectable
2f9wA-4rwfB:
10.05
2f9wB-4rwfB:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN
ADRENOMEDULLIN

(Escherichia
coli;
Homo
sapiens;
Homo
sapiens)
5 / 8 ARG A 356
TYR B  52
ASP A1098
ARG A1097
ILE A2041
None
1.36A 2f9wA-4rwfA:
undetectable
2f9wB-4rwfA:
undetectable
2f9wA-4rwfA:
17.98
2f9wB-4rwfA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo
sapiens)
5 / 12 LEU A 264
ILE A 110
VAL A  99
LEU A  78
ILE A  81
None
1.00A 2h42C-4rwfA:
undetectable
2h42C-4rwfA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo
sapiens)
4 / 6 ASP A 199
THR A 195
LYS A 202
ASP A 360
None
1.19A 2j2pE-4rwfA:
undetectable
2j2pF-4rwfA:
undetectable
2j2pE-4rwfA:
16.02
2j2pF-4rwfA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo
sapiens)
5 / 12 ALA A 266
LEU A 282
PHE A 281
VAL A 295
GLY A  18
None
None
None
None
EDO  A2203 ( 3.9A)
1.08A 2ve3A-4rwfA:
undetectable
2ve3A-4rwfA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo
sapiens)
4 / 8 LEU A 264
ILE A  62
TYR A  72
PHE A  69
None
0.99A 2weyB-4rwfA:
2.1
2weyB-4rwfA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo
sapiens)
4 / 8 THR A  95
LEU A 287
ASP A 289
GLU A 113
None
None
None
MAL  A2201 (-3.0A)
1.00A 2zw9A-4rwfA:
undetectable
2zw9A-4rwfA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo
sapiens)
4 / 6 ALA A 190
LEU A 194
ALA A 348
THR A 347
None
0.89A 3b6hA-4rwfA:
undetectable
3b6hA-4rwfA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo
sapiens)
4 / 6 ALA A 190
LEU A 194
ALA A 348
THR A 347
None
0.91A 3b6hB-4rwfA:
undetectable
3b6hB-4rwfA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo
sapiens)
4 / 6 PHE A 260
ALA A 164
LEU A 249
PRO A 161
None
0.95A 3bgdA-4rwfA:
undetectable
3bgdA-4rwfA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo
sapiens)
4 / 7 VAL A 112
GLY A 302
PRO A 231
LYS A 307
None
0.67A 3bjwC-4rwfA:
2.0
3bjwC-4rwfA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo
sapiens)
4 / 6 PRO A 128
LEU A 149
ALA A 225
PRO A 127
None
1.30A 3gv1A-4rwfA:
undetectable
3gv1C-4rwfA:
undetectable
3gv1A-4rwfA:
12.67
3gv1C-4rwfA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo
sapiens)
4 / 6 LEU A 149
ALA A 225
PRO A 127
PRO A 128
None
1.28A 3gv1A-4rwfA:
undetectable
3gv1B-4rwfA:
undetectable
3gv1A-4rwfA:
12.67
3gv1B-4rwfA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo
sapiens)
5 / 12 VAL A 345
GLY A 189
ALA A 190
LEU A 194
LEU A 162
None
1.02A 3hs6A-4rwfA:
undetectable
3hs6A-4rwfA:
21.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo
sapiens)
10 / 12 ASP A  16
LYS A  17
LYS A  44
GLU A  46
GLU A  47
ALA A  65
ASP A  67
ARG A  68
GLU A 113
TRP A 232
MAL  A2201 (-3.0A)
MAL  A2201 ( 2.7A)
None
None
None
MAL  A2201 (-3.4A)
MAL  A2201 (-2.8A)
MAL  A2201 (-3.8A)
MAL  A2201 (-3.0A)
MAL  A2201 ( 4.5A)
0.64A 3jyrA-4rwfA:
61.9
3jyrA-4rwfA:
61.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo
sapiens)
10 / 12 ASP A  16
LYS A  17
LYS A  44
GLU A  46
GLU A  47
ALA A  65
ASP A  67
GLU A 113
PRO A 156
TRP A 232
MAL  A2201 (-3.0A)
MAL  A2201 ( 2.7A)
None
None
None
MAL  A2201 (-3.4A)
MAL  A2201 (-2.8A)
MAL  A2201 (-3.0A)
MAL  A2201 (-3.4A)
MAL  A2201 ( 4.5A)
0.31A 3jyrA-4rwfA:
61.9
3jyrA-4rwfA:
61.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo
sapiens)
6 / 7 ASN A  14
GLU A 155
TYR A 157
MET A 332
TRP A 342
ARG A 346
MAL  A2201 (-4.6A)
MAL  A2201 (-3.7A)
MAL  A2201 (-3.9A)
MAL  A2201 ( 4.3A)
MAL  A2201 (-3.7A)
None
0.88A 3jyrA-4rwfA:
61.9
3jyrA-4rwfA:
61.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo
sapiens)
6 / 7 ASN A  14
TRP A  64
GLU A 155
TYR A 157
MET A 332
TRP A 342
MAL  A2201 (-4.6A)
MAL  A2201 (-4.3A)
MAL  A2201 (-3.7A)
MAL  A2201 (-3.9A)
MAL  A2201 ( 4.3A)
MAL  A2201 (-3.7A)
0.17A 3jyrA-4rwfA:
61.9
3jyrA-4rwfA:
61.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)
4rwf ADRENOMEDULLIN
MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo
sapiens)
4 / 5 ILE B  47
PHE A2095
ASP A2096
GLU A2099
None
0.71A 3kp6A-4rwfB:
undetectable
3kp6B-4rwfB:
undetectable
3kp6A-4rwfB:
14.29
3kp6B-4rwfB:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo
sapiens)
5 / 12 VAL A 198
LEU A 162
GLY A 189
ALA A 190
LEU A 363
None
1.00A 3n8yB-4rwfA:
undetectable
3n8yB-4rwfA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo
sapiens)
5 / 12 PHE A 158
GLY A 302
LEU A 301
GLU A 113
ALA A 233
None
None
None
MAL  A2201 (-3.0A)
None
0.86A 3tbgB-4rwfA:
undetectable
3tbgB-4rwfA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo
sapiens)
5 / 12 PHE A 158
GLY A 302
LEU A 301
GLU A 113
ALA A 233
None
None
None
MAL  A2201 (-3.0A)
None
0.84A 3tbgD-4rwfA:
undetectable
3tbgD-4rwfA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo
sapiens)
5 / 12 ALA A 233
TYR A  19
TYR A 212
ASN A 236
GLY A 230
None
EDO  A2203 (-3.4A)
None
None
None
1.34A 3vwqA-4rwfA:
undetectable
3vwqA-4rwfA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo
sapiens)
4 / 8 VAL A 112
GLN A 327
ILE A 331
MET A 323
None
1.09A 4iilA-4rwfA:
3.6
4iilA-4rwfA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo
sapiens)
4 / 5 ASN A 269
ALA A  53
GLY A  58
ASP A  16
None
None
None
MAL  A2201 (-3.0A)
0.97A 4n48A-4rwfA:
undetectable
4n48A-4rwfA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo
sapiens)
4 / 6 GLU A 155
GLU A1105
ASN A 351
ARG A 356
MAL  A2201 (-3.7A)
None
None
None
1.32A 4ntxA-4rwfA:
2.4
4ntxC-4rwfA:
1.7
4ntxA-4rwfA:
21.96
4ntxC-4rwfA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_B_ASCB304_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo
sapiens)
4 / 6 PHE A1121
HIS A1124
ILE A1120
TYR A1093
None
1.48A 4o7gB-4rwfA:
undetectable
4o7gB-4rwfA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKN_B_KANB403_1
(L-LACTATE
DEHYDROGENASE A
CHAIN)
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo
sapiens)
5 / 9 VAL A 304
TYR A  92
ALA A 314
ARG A 318
ILE A 319
None
1.48A 4oknB-4rwfA:
undetectable
4oknB-4rwfA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB602_1
(SERUM ALBUMIN)
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo
sapiens)
5 / 9 ALA A 266
ALA A 107
LEU A 105
LEU A 264
VAL A 263
None
1.13A 4or0B-4rwfA:
undetectable
4or0B-4rwfA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN
ADRENOMEDULLIN

(Escherichia
coli;
Homo
sapiens;
Homo
sapiens)
3 / 3 TYR A 343
TYR B  52
SER B  45
None
0.85A 5iktB-4rwfA:
undetectable
5iktB-4rwfA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo
sapiens)
6 / 12 ALA A 344
ALA A 340
GLY A 168
ALA A 190
PHE A 171
VAL A 183
None
EDO  A2204 ( 3.8A)
None
None
None
None
1.38A 5w4zA-4rwfA:
undetectable
5w4zA-4rwfA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo
sapiens)
6 / 12 ALA A 344
ALA A 340
GLY A 168
ALA A 190
PHE A 171
VAL A 183
None
EDO  A2204 ( 3.8A)
None
None
None
None
1.40A 5w4zB-4rwfA:
undetectable
5w4zB-4rwfA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo
sapiens)
5 / 11 PRO A 135
GLU A 132
PRO A 256
ALA A 165
PRO A 161
None
1.41A 6bm5A-4rwfA:
undetectable
6bm5A-4rwfA:
22.01