SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rwr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 4rwr STAGE II SPORULATION
PROTEIN D
(Bacillus
anthracis) 		5 / 9 THR A 288
LEU A 270
VAL A 264
ILE A 240
VAL A 252
 None
 1.46A 2l8mA-4rwrA:
undetectable		 2l8mA-4rwrA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 4rwr STAGE II SPORULATION
PROTEIN D
(Bacillus
anthracis) 		5 / 12 GLY A 294
ASN A 181
PHE A 176
ASP A 122
GLY A 292
 None
 1.39A 3ps9A-4rwrA:
undetectable		 3ps9A-4rwrA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 4rwr STAGE II SPORULATION
PROTEIN D
(Bacillus
anthracis) 		5 / 12 GLY A 294
ASN A 181
SER A 175
GLY A 246
SER A 200
 None
 1.07A 5hikA-4rwrA:
undetectable		 5hikA-4rwrA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 4rwr STAGE II SPORULATION
PROTEIN D
(Bacillus
anthracis) 		4 / 7 GLY A 301
ILE A 315
TRP A 205
TYR A 320
 None
 1.10A 5vlmC-4rwrA:
undetectable		 5vlmC-4rwrA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4rwr STAGE II SPORULATION
PROTEIN D
(Bacillus
anthracis) 		5 / 9 VAL A 264
VAL A 237
LEU A 268
GLN A 224
VAL A 286
 None
 1.36A 6czmB-4rwrA:
undetectable
6czmC-4rwrA:
undetectable		 6czmB-4rwrA:
20.69
6czmC-4rwrA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4rwr STAGE II SPORULATION
PROTEIN D
(Bacillus
anthracis) 		5 / 12 TRP A 277
PHE A 218
THR A 288
VAL A 286
THR A 260
 None
 1.21A 6djzB-4rwrA:
undetectable		 6djzB-4rwrA:
20.06