SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rws'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 4rws C-X-C CHEMOKINE
RECEPTOR TYPE
4/ENDOLYSIN CHIMERIC
PROTEIN
(Homo
sapiens;
Escherichia
virus
T4) 		4 / 7 LEU A1033
LEU A1015
GLY A1028
LEU A1066
 None
 0.90A 1gtiA-4rwsA:
undetectable		 1gtiA-4rwsA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4rws C-X-C CHEMOKINE
RECEPTOR TYPE
4/ENDOLYSIN CHIMERIC
PROTEIN
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 7 LEU A  91
SER A  46
PHE A  49
LEU A  50
 None
 0.72A 1j8uA-4rwsA:
undetectable		 1j8uA-4rwsA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA864_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4rws C-X-C CHEMOKINE
RECEPTOR TYPE
4/ENDOLYSIN CHIMERIC
PROTEIN
(Escherichia
virus
T4;
Homo
sapiens) 		3 / 3 TRP A 102
HIS A 113
LYS A 110
 None
 1.42A 1l7xA-4rwsA:
0.5		 1l7xA-4rwsA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 4rws C-X-C CHEMOKINE
RECEPTOR TYPE
4/ENDOLYSIN CHIMERIC
PROTEIN
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 8 SER A 227
SER A 224
ASN A1068
GLN A1069
 None
 1.07A 2cmlC-4rwsA:
undetectable		 2cmlC-4rwsA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4rws C-X-C CHEMOKINE
RECEPTOR TYPE
4/ENDOLYSIN CHIMERIC
PROTEIN
(Escherichia
virus
T4;
Homo
sapiens) 		3 / 3 LEU A  80
TRP A 125
TYR A  76
 None
 0.98A 3aicA-4rwsA:
undetectable		 3aicA-4rwsA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4rws C-X-C CHEMOKINE
RECEPTOR TYPE
4/ENDOLYSIN CHIMERIC
PROTEIN
(Escherichia
virus
T4;
Homo
sapiens) 		3 / 3 LEU A  80
TRP A 125
TYR A  76
 None
 0.93A 3aicB-4rwsA:
undetectable		 3aicB-4rwsA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4rws C-X-C CHEMOKINE
RECEPTOR TYPE
4/ENDOLYSIN CHIMERIC
PROTEIN
(Escherichia
virus
T4;
Homo
sapiens) 		3 / 3 LEU A  80
TRP A 125
TYR A  76
 None
 0.96A 3aicE-4rwsA:
undetectable		 3aicE-4rwsA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4rws C-X-C CHEMOKINE
RECEPTOR TYPE
4/ENDOLYSIN CHIMERIC
PROTEIN
(Escherichia
virus
T4;
Homo
sapiens) 		3 / 3 LEU A  80
TRP A 125
TYR A  76
 None
 0.97A 3aicG-4rwsA:
undetectable		 3aicG-4rwsA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4rws C-X-C CHEMOKINE
RECEPTOR TYPE
4/ENDOLYSIN CHIMERIC
PROTEIN
(Escherichia
virus
T4;
Homo
sapiens) 		3 / 3 LEU A  80
TRP A 125
TYR A  76
 None
 0.94A 3aicH-4rwsA:
undetectable		 3aicH-4rwsA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 4rws C-X-C CHEMOKINE
RECEPTOR TYPE
4/ENDOLYSIN CHIMERIC
PROTEIN
VIRAL MACROPHAGE
INFLAMMATORY PROTEIN
2
(Homo
sapiens;
Escherichia
virus
T4;
Human
gammaherpesvirus
8) 		4 / 6 GLY C   2
GLU A 288
ASP A  97
ASN A  37
 None
 1.02A 3vywC-4rwsC:
undetectable		 3vywC-4rwsC:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 4rws C-X-C CHEMOKINE
RECEPTOR TYPE
4/ENDOLYSIN CHIMERIC
PROTEIN
VIRAL MACROPHAGE
INFLAMMATORY PROTEIN
2
(Escherichia
virus
T4;
Homo
sapiens;
Human
gammaherpesvirus
8) 		4 / 6 GLU A  31
ASP C   9
GLU A 179
ASN A 101
 None
 1.35A 4ntxA-4rwsA:
2.2
4ntxC-4rwsA:
2.2		 4ntxA-4rwsA:
21.36
4ntxC-4rwsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 4rws C-X-C CHEMOKINE
RECEPTOR TYPE
4/ENDOLYSIN CHIMERIC
PROTEIN
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 9 VAL A 156
GLY A 159
ILE A 215
LEU A 127
ASP A 133
 None
 1.30A 6c2mC-4rwsA:
undetectable		 6c2mC-4rwsA:
10.18