SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rwy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)		 4rwy ANTIBODY 8ANC131
HEAVY CHAIN
(Homo
sapiens) 		4 / 8 GLN H   6
VAL H 109
GLY H   8
GLY H   9
 None
None
EDO  H 304 ( 3.5A)
EDO  H 304 ( 3.7A)
 0.70A 1ekjE-4rwyH:
undetectable
1ekjF-4rwyH:
undetectable		 1ekjE-4rwyH:
23.27
1ekjF-4rwyH:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4rwy ANTIBODY 8ANC131
HEAVY CHAIN
(Homo
sapiens) 		5 / 12 ILE H  37
ALA H  93
LEU H   4
LEU H  97
LEU H  50
 None
 1.29A 1g5yB-4rwyH:
undetectable		 1g5yB-4rwyH:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TF1_A_ACTA191_0
(METHYL-ACCEPTING
CHEMOTAXIS PROTEIN)		 4rwy ANTIBODY 8ANC131
HEAVY CHAIN
(Homo
sapiens) 		4 / 5 THR H 112
ILE H 110
PHE H 146
LEU H 170
 None
 1.20A 3tf1A-4rwyH:
3.2		 3tf1A-4rwyH:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 4rwy ANTIBODY 8ANC131
HEAVY CHAIN
(Homo
sapiens) 		4 / 8 TYR H  90
ASP H  85
PHE H  63
LEU H  48
 None
 0.80A 4f8hA-4rwyH:
undetectable
4f8hB-4rwyH:
3.3		 4f8hA-4rwyH:
22.12
4f8hB-4rwyH:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 4rwy ANTIBODY 8ANC131
HEAVY CHAIN
(Homo
sapiens) 		4 / 8 TYR H  90
ASP H  85
PHE H  63
LEU H  48
 None
 0.83A 4f8hB-4rwyH:
3.3
4f8hC-4rwyH:
undetectable		 4f8hB-4rwyH:
22.12
4f8hC-4rwyH:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 4rwy ANTIBODY 8ANC131
HEAVY CHAIN
(Homo
sapiens) 		4 / 8 TYR H  90
ASP H  85
PHE H  63
LEU H  48
 None
 0.80A 4f8hC-4rwyH:
undetectable
4f8hD-4rwyH:
undetectable		 4f8hC-4rwyH:
22.12
4f8hD-4rwyH:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 4rwy ANTIBODY 8ANC131
HEAVY CHAIN
(Homo
sapiens) 		4 / 8 TYR H  90
ASP H  85
PHE H  63
LEU H  48
 None
 0.80A 4f8hD-4rwyH:
undetectable
4f8hE-4rwyH:
undetectable		 4f8hD-4rwyH:
22.12
4f8hE-4rwyH:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 4rwy ANTIBODY 8ANC131
HEAVY CHAIN
(Homo
sapiens) 		4 / 8 PHE H  63
LEU H  48
TYR H  90
ASP H  85
 None
 0.81A 4f8hA-4rwyH:
undetectable
4f8hE-4rwyH:
undetectable		 4f8hA-4rwyH:
22.12
4f8hE-4rwyH:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 4rwy ANTIBODY 8ANC131
HEAVY CHAIN
(Homo
sapiens) 		4 / 6 TYR H 194
GLY H 134
SER H 187
LEU H 189
 None
 1.19A 5bphA-4rwyH:
undetectable		 5bphA-4rwyH:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_C_ACTC403_0
(D-ALANINE--D-ALANINE
LIGASE)		 4rwy ANTIBODY 8ANC131
HEAVY CHAIN
(Homo
sapiens) 		4 / 4 TYR H 194
GLY H 134
SER H 187
LEU H 189
 None
 1.15A 5bphC-4rwyH:
undetectable		 5bphC-4rwyH:
22.92