SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rx1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_2
(HIV-1 PROTEASE)		 4rx1 PUTATIVE RRNA
METHYLTRANSFERASE
(Sorangium
cellulosum) 		5 / 12 LEU A 101
GLY A  96
ILE A  52
VAL A  31
ILE A  29
 None
 0.87A 2hs1B-4rx1A:
undetectable		 2hs1B-4rx1A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4rx1 PUTATIVE RRNA
METHYLTRANSFERASE
(Sorangium
cellulosum) 		4 / 6 ILE A  29
VAL A  31
LEU A 103
LEU A 135
 None
 0.76A 3kp6A-4rx1A:
undetectable
3kp6B-4rx1A:
undetectable		 3kp6A-4rx1A:
20.51
3kp6B-4rx1A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 4rx1 PUTATIVE RRNA
METHYLTRANSFERASE
(Sorangium
cellulosum) 		5 / 12 GLY A  32
GLY A  34
PRO A  56
PHE A 105
LEU A 110
 GOL  A 303 (-3.7A)
None
None
None
None
 0.75A 3mteB-4rx1A:
25.4		 3mteB-4rx1A:
29.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 4rx1 PUTATIVE RRNA
METHYLTRANSFERASE
(Sorangium
cellulosum) 		5 / 12 GLY A  32
GLY A  34
PRO A  56
PHE A 105
LEU A 110
 GOL  A 303 (-3.7A)
None
None
None
None
 0.72A 3p2kC-4rx1A:
25.0		 3p2kC-4rx1A:
28.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 4rx1 PUTATIVE RRNA
METHYLTRANSFERASE
(Sorangium
cellulosum) 		4 / 5 ASN A  79
ALA A  43
TYR A  40
ALA A  68
 None
 1.32A 3twpD-4rx1A:
3.4		 3twpD-4rx1A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 4rx1 PUTATIVE RRNA
METHYLTRANSFERASE
(Sorangium
cellulosum) 		5 / 11 LEU A 111
ALA A 113
GLU A 118
GLY A  32
LEU A 103
 None
None
None
GOL  A 303 (-3.7A)
None
 1.27A 3uudA-4rx1A:
undetectable		 3uudA-4rx1A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 4rx1 PUTATIVE RRNA
METHYLTRANSFERASE
(Sorangium
cellulosum) 		5 / 11 ILE A 178
LEU A 135
LEU A 114
ALA A 137
LEU A 158
 None
 1.00A 4p65E-4rx1A:
undetectable
4p65F-4rx1A:
undetectable
4p65J-4rx1A:
undetectable
4p65L-4rx1A:
undetectable		 4p65E-4rx1A:
7.28
4p65F-4rx1A:
15.38
4p65J-4rx1A:
15.38
4p65L-4rx1A:
15.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 4rx1 PUTATIVE RRNA
METHYLTRANSFERASE
(Sorangium
cellulosum) 		5 / 12 GLY A  32
GLY A  34
ASP A  55
PRO A  56
TRP A 107
 GOL  A 303 (-3.7A)
None
GOL  A 303 ( 4.2A)
None
GOL  A 303 (-3.2A)
 0.59A 5bw4A-4rx1A:
25.7		 5bw4A-4rx1A:
34.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 4rx1 PUTATIVE RRNA
METHYLTRANSFERASE
(Sorangium
cellulosum) 		5 / 12 GLY A  32
GLY A  34
PRO A  56
TRP A 107
LEU A 110
 GOL  A 303 (-3.7A)
None
None
GOL  A 303 (-3.2A)
None
 0.93A 5bw4A-4rx1A:
25.7		 5bw4A-4rx1A:
34.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 4rx1 PUTATIVE RRNA
METHYLTRANSFERASE
(Sorangium
cellulosum) 		4 / 5 LEU A  81
LYS A   1
LEU A  17
GLU A  93
 None
 1.15A 5weaA-4rx1A:
2.5		 5weaA-4rx1A:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 4rx1 PUTATIVE RRNA
METHYLTRANSFERASE
(Sorangium
cellulosum) 		5 / 12 GLY A  32
GLY A  34
ASP A  55
SER A  86
VAL A  87
 GOL  A 303 (-3.7A)
None
GOL  A 303 ( 4.2A)
None
IOD  A 302 ( 4.3A)
 0.67A 5wy0A-4rx1A:
10.8		 5wy0A-4rx1A:
23.51