SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rx4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 4rx4 8ANC134 LIGHT CHAIN
(Homo
sapiens) 		4 / 7 LEU L 135
THR L 172
SER L 162
THR L 164
 None
 0.67A 1ictD-4rx4L:
2.8		 1ictD-4rx4L:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4rx4 8ANC134 LIGHT CHAIN
(Homo
sapiens) 		4 / 5 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.90A 2aojA-4rx4L:
undetectable		 2aojA-4rx4L:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 4rx4 HIV-1 CLADE A
Q842.D12 GP120
(Human
immunodeficiency
virus
1) 		5 / 9 THR G 387
LEU G 416
VAL G 333
ILE G 449
VAL G 292
 None
 1.49A 2l8mA-4rx4G:
undetectable		 2l8mA-4rx4G:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4rx4 HIV-1 CLADE A
Q842.D12 GP120
(Human
immunodeficiency
virus
1) 		5 / 12 GLY G 250
TYR G 217
ALA G  70
PRO G 253
LEU G 111
 EDO  G 510 ( 4.3A)
None
None
None
None
 0.98A 3tm4B-4rx4G:
undetectable		 3tm4B-4rx4G:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 4rx4 HIV-1 CLADE A
Q842.D12 GP120
(Human
immunodeficiency
virus
1) 		3 / 3 SER G 375
PHE G 382
LYS G 421
 None
None
SO4  G 511 (-4.3A)
 0.95A 3u88A-4rx4G:
undetectable		 3u88A-4rx4G:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 4rx4 HIV-1 CLADE A
Q842.D12 GP120
(Human
immunodeficiency
virus
1) 		5 / 12 PHE G 391
ASN G 332
VAL G 292
ILE G 449
LEU G 452
 None
NAG  G 502 (-4.3A)
None
None
None
 1.42A 4k39A-4rx4G:
undetectable		 4k39A-4rx4G:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 4rx4 HIV-1 CLADE A
Q842.D12 GP120
(Human
immunodeficiency
virus
1) 		4 / 4 VAL G  89
THR G  90
GLU G  91
GLU G  92
 None
 1.38A 4l78A-4rx4G:
undetectable		 4l78A-4rx4G:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 4rx4 HIV-1 CLADE A
Q842.D12 GP120
(Human
immunodeficiency
virus
1) 		5 / 7 ASP G 477
GLY G 472
HIS G 105
ASP G 474
ASN G 478
 EDO  G 509 (-2.1A)
None
None
EDO  G 509 (-3.4A)
None
 1.32A 5nnwD-4rx4G:
undetectable		 5nnwD-4rx4G:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 4rx4 HIV-1 CLADE A
Q842.D12 GP120
(Human
immunodeficiency
virus
1) 		5 / 7 ASP G 477
GLY G 472
HIS G 105
ASP G 474
ASN G 478
 EDO  G 509 (-2.1A)
None
None
EDO  G 509 (-3.4A)
None
 1.32A 5no9D-4rx4G:
undetectable		 5no9D-4rx4G:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 4rx4 HIV-1 CLADE A
Q842.D12 GP120
(Human
immunodeficiency
virus
1) 		4 / 6 PHE G 468
LEU G 452
ARG G 469
GLY G 471
 None
None
EDO  G 513 ( 4.8A)
None
 1.12A 5o4yA-4rx4G:
undetectable		 5o4yA-4rx4G:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 4rx4 HIV-1 CLADE A
Q842.D12 GP120
(Human
immunodeficiency
virus
1) 		3 / 3 TRP G  69
ILE G 109
ASP G 107
 None
 0.87A 6i0y7-4rx4G:
undetectable		 6i0y7-4rx4G:
8.20