SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rxe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_2
(CARBONIC ANHYDRASE
II)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		4 / 4 HIS A 121
VAL A 124
THR A  42
LEU A 135
 None
 1.43A 1oq5A-4rxeA:
undetectable		 1oq5A-4rxeA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 11 ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
THR A 213
GLN A 252
ASP A 255
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
 0.35A 1rqjA-4rxeA:
29.8		 1rqjA-4rxeA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		6 / 11 ASP A 103
ASP A 107
ARG A 112
GLN A 252
ASP A 255
LYS A 269
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 0.88A 1rqjA-4rxeA:
29.8		 1rqjA-4rxeA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		6 / 11 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 172
ASP A 255
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
MG  A3003 ( 2.9A)
 0.65A 1rqjA-4rxeA:
29.8		 1rqjA-4rxeA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 11 ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
THR A 213
GLN A 252
ASP A 255
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
 0.35A 1rqjB-4rxeA:
29.9		 1rqjB-4rxeA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 11 ASP A 107
ARG A 112
GLN A 252
ASP A 255
LYS A 269
 MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 0.93A 1rqjB-4rxeA:
29.9		 1rqjB-4rxeA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		7 / 11 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
ASP A 255
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
MG  A3003 ( 2.9A)
 0.61A 1rqjB-4rxeA:
29.9		 1rqjB-4rxeA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		3 / 3 LEU A 135
LEU A  17
MET A  27
 None
 0.73A 1ya3B-4rxeA:
undetectable		 1ya3B-4rxeA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE509_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		4 / 6 GLU A 330
TYR A 250
ARG A 365
LYS A 364
 None
 1.29A 1yc2A-4rxeA:
undetectable
1yc2B-4rxeA:
undetectable
1yc2E-4rxeA:
undetectable		 1yc2A-4rxeA:
20.97
1yc2B-4rxeA:
20.97
1yc2E-4rxeA:
20.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		9 / 11 ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
THR A 213
GLN A 252
ASP A 255
LYS A 269
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 0.78A 1yhlA-4rxeA:
52.9		 1yhlA-4rxeA:
66.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		9 / 11 ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
THR A 213
TYR A 216
GLN A 252
ASP A 255
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 (-4.7A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
 0.30A 1yhlA-4rxeA:
52.9		 1yhlA-4rxeA:
66.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 11 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
TYR A 216
ASP A 255
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.7A)
MG  A3003 ( 2.9A)
 0.57A 1yhlA-4rxeA:
52.9		 1yhlA-4rxeA:
66.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		9 / 11 ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
THR A 213
GLN A 252
ASP A 255
LYS A 269
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 0.70A 1yq7A-4rxeA:
42.7		 1yq7A-4rxeA:
38.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		9 / 11 ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
THR A 213
TYR A 216
GLN A 252
ASP A 255
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 (-4.7A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
 0.34A 1yq7A-4rxeA:
42.7		 1yq7A-4rxeA:
38.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		9 / 11 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
THR A 213
ASP A 255
LYS A 269
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 0.82A 1yq7A-4rxeA:
42.7		 1yq7A-4rxeA:
38.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		9 / 11 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
THR A 213
TYR A 216
ASP A 255
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 (-4.7A)
MG  A3003 ( 2.9A)
 0.55A 1yq7A-4rxeA:
42.7		 1yq7A-4rxeA:
38.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 10 ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
THR A 213
GLN A 252
ASP A 255
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
 0.31A 1yv5A-4rxeA:
42.9		 1yv5A-4rxeA:
38.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 10 ASP A 103
ASP A 107
GLN A 172
LYS A 212
THR A 213
GLN A 252
ASP A 255
LYS A 269
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 0.74A 1yv5A-4rxeA:
42.9		 1yv5A-4rxeA:
38.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		7 / 10 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
ASP A 255
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
MG  A3003 ( 2.9A)
 0.54A 1yv5A-4rxeA:
42.9		 1yv5A-4rxeA:
38.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 10 LEU A 100
ASP A 103
ASP A 107
ARG A 112
THR A 168
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
None
 1.24A 1yv5A-4rxeA:
42.9		 1yv5A-4rxeA:
38.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZW5_A_ZOLA901_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 9 ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
THR A 213
GLN A 252
ASP A 255
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
 0.33A 1zw5A-4rxeA:
43.8		 1zw5A-4rxeA:
36.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZW5_A_ZOLA901_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 9 ASP A 103
ASP A 107
GLN A 172
LYS A 212
THR A 213
GLN A 252
ASP A 255
LYS A 269
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 0.79A 1zw5A-4rxeA:
43.8		 1zw5A-4rxeA:
36.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 9 ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
THR A 213
GLN A 252
ASP A 255
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
 0.33A 2e91A-4rxeA:
24.8		 2e91A-4rxeA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_B_ZOLB902_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 9 ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
THR A 213
GLN A 252
ASP A 255
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
 0.51A 2e91B-4rxeA:
23.9		 2e91B-4rxeA:
21.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F89_F_210F9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 9 ASP A 103
ASP A 107
ARG A 112
LYS A 212
THR A 213
TYR A 216
GLN A 252
ASP A 255
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 (-4.7A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
 0.27A 2f89F-4rxeA:
44.4		 2f89F-4rxeA:
36.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F89_F_210F9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		7 / 9 ASP A 103
ASP A 107
LYS A 212
THR A 213
GLN A 252
ASP A 255
LYS A 269
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 0.79A 2f89F-4rxeA:
44.4		 2f89F-4rxeA:
36.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		9 / 11 ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
THR A 213
TYR A 216
GLN A 252
ASP A 255
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 (-4.7A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
 0.29A 2f8cF-4rxeA:
43.6		 2f8cF-4rxeA:
36.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		7 / 11 ASP A 103
ASP A 107
GLN A 172
LYS A 212
GLN A 252
ASP A 255
LYS A 269
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 0.75A 2f8cF-4rxeA:
43.6		 2f8cF-4rxeA:
36.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 11 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
TYR A 216
ASP A 255
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.7A)
MG  A3003 ( 2.9A)
 0.52A 2f8cF-4rxeA:
43.6		 2f8cF-4rxeA:
36.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 10 ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
THR A 213
GLN A 252
ASP A 255
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
 0.30A 2f8zF-4rxeA:
44.2		 2f8zF-4rxeA:
36.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 10 ASP A 103
ASP A 107
GLN A 172
LYS A 212
THR A 213
GLN A 252
ASP A 255
LYS A 269
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 0.80A 2f8zF-4rxeA:
44.2		 2f8zF-4rxeA:
36.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 10 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
THR A 213
ASP A 255
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
MG  A3003 ( 2.9A)
 0.55A 2f8zF-4rxeA:
44.2		 2f8zF-4rxeA:
36.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		11 / 12 LEU A 100
ASP A 103
ASP A 107
ARG A 112
THR A 168
GLN A 172
LYS A 212
THR A 213
TYR A 216
GLN A 252
ASP A 255
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
None
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 (-4.7A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
 0.66A 2f94F-4rxeA:
43.3		 2f94F-4rxeA:
36.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		11 / 12 LEU A 100
ASP A 103
ASP A 107
THR A 168
GLN A 172
LYS A 212
THR A 213
TYR A 216
GLN A 252
ASP A 255
LYS A 269
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
None
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 (-4.7A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 0.85A 2f94F-4rxeA:
43.3		 2f94F-4rxeA:
36.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 10 ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
THR A 213
GLN A 252
ASP A 255
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
 0.29A 2f9kF-4rxeA:
43.6		 2f9kF-4rxeA:
36.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 10 ASP A 103
ASP A 107
GLN A 172
LYS A 212
THR A 213
GLN A 252
ASP A 255
LYS A 269
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 0.75A 2f9kF-4rxeA:
43.6		 2f9kF-4rxeA:
36.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		6 / 10 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 172
ASP A 255
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
MG  A3003 ( 2.9A)
 0.63A 2f9kF-4rxeA:
43.6		 2f9kF-4rxeA:
36.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		6 / 10 LEU A 100
ASP A 103
ASP A 107
GLN A 172
ASP A 255
LYS A 269
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
MG  A3004 ( 3.8A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 0.97A 2f9kF-4rxeA:
43.6		 2f9kF-4rxeA:
36.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		7 / 9 ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
THR A 213
GLN A 252
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
 0.48A 2o1oA-4rxeA:
36.3		 2o1oA-4rxeA:
30.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 9 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 172
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
 0.58A 2o1oA-4rxeA:
36.3		 2o1oA-4rxeA:
30.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		7 / 10 ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
THR A 213
GLN A 252
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
 0.49A 2o1oB-4rxeA:
36.8		 2o1oB-4rxeA:
30.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		6 / 10 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
 0.66A 2o1oB-4rxeA:
36.8		 2o1oB-4rxeA:
30.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 10 ASP A 103
ARG A 112
GLN A 172
LYS A 212
ASP A 273
 MG  A3004 (-2.5A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
MG  A3003 (-3.6A)
 1.37A 2q58A-4rxeA:
36.1		 2q58A-4rxeA:
30.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 10 ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
THR A 213
GLN A 252
ASP A 256
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
None
 0.61A 2q58A-4rxeA:
36.1		 2q58A-4rxeA:
30.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Q58_B_ZOLB2_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		7 / 9 ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
THR A 213
GLN A 252
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
 0.52A 2q58B-4rxeA:
36.2		 2q58B-4rxeA:
30.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QIS_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		7 / 10 ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
GLN A 252
ASP A 255
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
 0.28A 2qisA-4rxeA:
43.2		 2qisA-4rxeA:
37.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QIS_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		7 / 10 ASP A 103
ASP A 107
GLN A 172
LYS A 212
GLN A 252
ASP A 255
LYS A 269
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 0.80A 2qisA-4rxeA:
43.2		 2qisA-4rxeA:
37.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QIS_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		6 / 10 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 172
ASP A 255
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
MG  A3003 ( 2.9A)
 0.60A 2qisA-4rxeA:
43.2		 2qisA-4rxeA:
37.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		4 / 9 PHE A 351
ALA A 352
VAL A 355
GLU A 356
 None
 0.47A 2vufA-4rxeA:
undetectable		 2vufA-4rxeA:
21.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EZ3_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 9 ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
THR A 213
GLN A 252
ASP A 255
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
 0.44A 3ez3A-4rxeA:
43.4		 3ez3A-4rxeA:
34.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EZ3_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 9 ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
THR A 213
GLN A 252
ASP A 255
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
 0.32A 3ez3B-4rxeA:
42.7		 3ez3B-4rxeA:
34.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EZ3_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 9 ASP A 107
THR A 213
GLN A 252
ASP A 255
LYS A 269
 MG  A3004 (-2.3A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 1.01A 3ez3B-4rxeA:
42.7		 3ez3B-4rxeA:
34.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EZ3_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 9 ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
THR A 213
GLN A 252
ASP A 255
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
 0.44A 3ez3C-4rxeA:
43.4		 3ez3C-4rxeA:
34.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EZ3_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 9 ASP A 107
THR A 213
GLN A 252
ASP A 255
LYS A 269
 MG  A3004 (-2.3A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 0.97A 3ez3C-4rxeA:
43.4		 3ez3C-4rxeA:
34.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 10 ASP A 107
THR A 213
GLN A 252
ASP A 255
LYS A 269
 MG  A3004 (-2.3A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 0.99A 3ez3D-4rxeA:
42.3		 3ez3D-4rxeA:
34.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		9 / 10 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
THR A 213
GLN A 252
ASP A 255
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
 0.54A 3ez3D-4rxeA:
42.3		 3ez3D-4rxeA:
34.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 10 LEU A 100
ASP A 103
ASP A 107
ARG A 112
THR A 168
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
None
 1.22A 3ez3D-4rxeA:
42.3		 3ez3D-4rxeA:
34.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IBA_A_ZOLA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		10 / 10 ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
THR A 213
TYR A 216
GLN A 252
ASP A 255
LYS A 269
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 (-4.7A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 0.77A 3ibaA-4rxeA:
52.9		 3ibaA-4rxeA:
66.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LDW_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 9 ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
THR A 213
GLN A 252
ASP A 255
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
 0.44A 3ldwA-4rxeA:
43.3		 3ldwA-4rxeA:
34.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LDW_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 9 ASP A 107
THR A 213
GLN A 252
ASP A 255
LYS A 269
 MG  A3004 (-2.3A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 0.99A 3ldwA-4rxeA:
43.3		 3ldwA-4rxeA:
34.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LDW_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 9 ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
THR A 213
GLN A 252
ASP A 255
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
 0.32A 3ldwB-4rxeA:
42.7		 3ldwB-4rxeA:
34.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LDW_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 9 ASP A 107
THR A 213
GLN A 252
ASP A 255
LYS A 269
 MG  A3004 (-2.3A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 1.01A 3ldwB-4rxeA:
42.7		 3ldwB-4rxeA:
34.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LDW_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 9 ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
THR A 213
GLN A 252
ASP A 255
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
 0.41A 3ldwC-4rxeA:
43.3		 3ldwC-4rxeA:
34.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LDW_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 9 ASP A 107
THR A 213
GLN A 252
ASP A 255
LYS A 269
 MG  A3004 (-2.3A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 0.98A 3ldwC-4rxeA:
43.3		 3ldwC-4rxeA:
34.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LDW_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 9 ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
THR A 213
GLN A 252
ASP A 255
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
 0.33A 3ldwD-4rxeA:
42.4		 3ldwD-4rxeA:
34.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LDW_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 9 ASP A 107
THR A 213
GLN A 252
ASP A 255
LYS A 269
 MG  A3004 (-2.3A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 1.00A 3ldwD-4rxeA:
42.4		 3ldwD-4rxeA:
34.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		9 / 11 ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
THR A 213
TYR A 216
GLN A 252
ASP A 255
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 (-4.7A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
 0.29A 3n45F-4rxeA:
43.7		 3n45F-4rxeA:
36.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		7 / 11 ASP A 103
ASP A 107
GLN A 172
LYS A 212
GLN A 252
ASP A 255
LYS A 269
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 0.78A 3n45F-4rxeA:
43.7		 3n45F-4rxeA:
36.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		7 / 11 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 172
TYR A 216
ASP A 255
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-4.7A)
MG  A3003 ( 2.9A)
 0.61A 3n45F-4rxeA:
43.7		 3n45F-4rxeA:
36.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 10 ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
THR A 213
GLN A 252
ASP A 255
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
 0.32A 3n46F-4rxeA:
43.7		 3n46F-4rxeA:
36.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		7 / 10 ASP A 103
ASP A 107
GLN A 172
LYS A 212
GLN A 252
ASP A 255
LYS A 269
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 0.80A 3n46F-4rxeA:
43.7		 3n46F-4rxeA:
36.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 10 LEU A 100
ASP A 103
ASP A 107
ARG A 112
ASP A 255
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3003 ( 2.9A)
 0.67A 3n46F-4rxeA:
43.7		 3n46F-4rxeA:
36.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		4 / 7 ASN A  49
GLN A 366
TYR A 363
TYR A 218
 None
 1.27A 3ugrA-4rxeA:
undetectable		 3ugrA-4rxeA:
21.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KFA_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		7 / 9 ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
GLN A 252
ASP A 255
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
 0.37A 4kfaA-4rxeA:
42.7		 4kfaA-4rxeA:
38.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KFA_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		7 / 9 ASP A 103
ASP A 107
GLN A 172
LYS A 212
GLN A 252
ASP A 255
LYS A 269
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 0.84A 4kfaA-4rxeA:
42.7		 4kfaA-4rxeA:
38.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KFA_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 9 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 172
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
 0.56A 4kfaA-4rxeA:
42.7		 4kfaA-4rxeA:
38.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		7 / 10 ASP A 103
ASP A 107
GLN A 172
LYS A 212
GLN A 252
ASP A 255
LYS A 269
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 0.81A 4kpdA-4rxeA:
43.6		 4kpdA-4rxeA:
38.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		9 / 10 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
THR A 213
GLN A 252
ASP A 255
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
 0.51A 4kpdA-4rxeA:
43.6		 4kpdA-4rxeA:
38.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		7 / 9 ASP A 103
ASP A 107
ARG A 112
LYS A 212
THR A 213
GLN A 252
ASP A 255
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
 0.29A 4kpjA-4rxeA:
42.8		 4kpjA-4rxeA:
38.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		7 / 9 ASP A 103
ASP A 107
LYS A 212
THR A 213
GLN A 252
ASP A 255
LYS A 269
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 0.79A 4kpjA-4rxeA:
42.8		 4kpjA-4rxeA:
38.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 9 LEU A 100
ASP A 103
ASP A 107
ARG A 112
THR A 168
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
None
 1.25A 4kpjA-4rxeA:
42.8		 4kpjA-4rxeA:
38.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 10 ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
THR A 213
GLN A 252
ASP A 255
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
 0.33A 4kq5A-4rxeA:
43.1		 4kq5A-4rxeA:
38.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		7 / 10 ASP A 103
ASP A 107
GLN A 172
THR A 213
GLN A 252
ASP A 255
LYS A 269
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 0.88A 4kq5A-4rxeA:
43.1		 4kq5A-4rxeA:
38.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 10 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 172
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
 0.64A 4kq5A-4rxeA:
43.1		 4kq5A-4rxeA:
38.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 10 ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
THR A 213
GLN A 252
ASP A 255
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
 0.28A 4kqsA-4rxeA:
43.4		 4kqsA-4rxeA:
38.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 10 ASP A 103
ASP A 107
GLN A 172
LYS A 212
THR A 213
GLN A 252
ASP A 255
LYS A 269
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 0.75A 4kqsA-4rxeA:
43.4		 4kqsA-4rxeA:
38.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		7 / 10 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
ASP A 255
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
MG  A3003 ( 2.9A)
 0.54A 4kqsA-4rxeA:
43.4		 4kqsA-4rxeA:
38.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 10 LEU A 100
ASP A 103
ASP A 107
ARG A 112
THR A 168
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
None
 1.22A 4kqsA-4rxeA:
43.4		 4kqsA-4rxeA:
38.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 9 LEU A 222
LEU A  61
PHE A 351
THR A 240
LEU A 243
 None
 1.20A 4ltwA-4rxeA:
1.9		 4ltwA-4rxeA:
21.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 10 ASP A 103
ASP A 107
ARG A 112
THR A 168
GLN A 172
THR A 213
GLN A 252
ASP A 255
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
None
MG  A3004 ( 3.8A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
 0.30A 4n9uA-4rxeA:
42.6		 4n9uA-4rxeA:
38.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		6 / 10 ASP A 103
ASP A 107
GLN A 172
GLN A 252
ASP A 255
LYS A 269
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
MG  A3004 ( 3.8A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 0.85A 4n9uA-4rxeA:
42.6		 4n9uA-4rxeA:
38.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		7 / 10 LEU A 100
ASP A 103
ASP A 107
ARG A 112
THR A 168
GLN A 172
ASP A 255
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
None
MG  A3004 ( 3.8A)
MG  A3003 ( 2.9A)
 0.57A 4n9uA-4rxeA:
42.6		 4n9uA-4rxeA:
38.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 10 LEU A 100
ASP A 103
ASP A 107
ARG A 112
THR A 213
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
3YQ  A3001 (-4.2A)
 1.43A 4n9uA-4rxeA:
42.6		 4n9uA-4rxeA:
38.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		9 / 12 ASP A 103
ASP A 107
ARG A 112
THR A 168
GLN A 172
THR A 213
TYR A 216
GLN A 252
ASP A 255
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
None
MG  A3004 ( 3.8A)
3YQ  A3001 (-4.2A)
3YQ  A3001 (-4.7A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
 0.57A 4ng6A-4rxeA:
43.8		 4ng6A-4rxeA:
38.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 12 ASP A 103
ASP A 107
GLN A 172
THR A 213
TYR A 216
GLN A 252
ASP A 255
LYS A 269
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-4.2A)
3YQ  A3001 (-4.7A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 0.90A 4ng6A-4rxeA:
43.8		 4ng6A-4rxeA:
38.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		9 / 12 LEU A 100
ASP A 103
ASP A 107
ARG A 112
THR A 168
GLN A 172
THR A 213
TYR A 216
ASP A 255
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
None
MG  A3004 ( 3.8A)
3YQ  A3001 (-4.2A)
3YQ  A3001 (-4.7A)
MG  A3003 ( 2.9A)
 0.69A 4ng6A-4rxeA:
43.8		 4ng6A-4rxeA:
38.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		9 / 10 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
THR A 213
GLN A 252
ASP A 255
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
 0.48A 4nkeA-4rxeA:
42.9		 4nkeA-4rxeA:
38.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 10 LEU A 100
ASP A 103
ASP A 107
ARG A 112
THR A 168
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
None
 1.19A 4nkeA-4rxeA:
42.9		 4nkeA-4rxeA:
38.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		9 / 10 LEU A 100
ASP A 103
ASP A 107
GLN A 172
LYS A 212
THR A 213
GLN A 252
ASP A 255
LYS A 269
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 0.66A 4nkeA-4rxeA:
42.9		 4nkeA-4rxeA:
38.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		7 / 9 ASP A 103
ASP A 107
ARG A 112
LYS A 212
THR A 213
GLN A 252
ASP A 255
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
 0.34A 4nkfA-4rxeA:
42.8		 4nkfA-4rxeA:
38.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		7 / 9 ASP A 103
ASP A 107
LYS A 212
THR A 213
GLN A 252
ASP A 255
LYS A 269
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 0.79A 4nkfA-4rxeA:
42.8		 4nkfA-4rxeA:
38.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 9 LEU A 100
ASP A 103
ASP A 107
ARG A 112
ASP A 255
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3003 ( 2.9A)
 0.62A 4nkfA-4rxeA:
42.8		 4nkfA-4rxeA:
38.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 6 ARG A 365
ASP A 255
GLU A 249
VAL A 284
ALA A 283
 None
MG  A3003 ( 2.9A)
None
None
None
 1.50A 4nkxA-4rxeA:
undetectable		 4nkxA-4rxeA:
21.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 10 ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
THR A 213
GLN A 252
ASP A 255
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
 0.26A 4nuaA-4rxeA:
42.9		 4nuaA-4rxeA:
38.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 10 ASP A 103
ASP A 107
GLN A 172
LYS A 212
THR A 213
GLN A 252
ASP A 255
LYS A 269
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 0.48A 4nuaA-4rxeA:
42.9		 4nuaA-4rxeA:
38.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		7 / 10 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
ASP A 255
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
MG  A3003 ( 2.9A)
 0.53A 4nuaA-4rxeA:
42.9		 4nuaA-4rxeA:
38.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 10 LEU A 100
ASP A 103
ASP A 107
ARG A 112
THR A 168
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
None
 1.22A 4nuaA-4rxeA:
42.9		 4nuaA-4rxeA:
38.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		7 / 10 LEU A 100
ASP A 103
ASP A 107
GLN A 172
LYS A 212
ASP A 255
LYS A 269
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 0.68A 4nuaA-4rxeA:
42.9		 4nuaA-4rxeA:
38.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		7 / 9 ASP A 103
ASP A 107
ARG A 112
LYS A 212
THR A 213
GLN A 252
ASP A 255
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
 0.33A 4oguA-4rxeA:
42.8		 4oguA-4rxeA:
38.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		7 / 9 ASP A 103
ASP A 107
LYS A 212
THR A 213
GLN A 252
ASP A 255
LYS A 269
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 0.83A 4oguA-4rxeA:
42.8		 4oguA-4rxeA:
38.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		6 / 9 LEU A 100
ASP A 103
ASP A 107
ARG A 112
LYS A 212
ASP A 255
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
3YQ  A3001 (-2.9A)
MG  A3003 ( 2.9A)
 0.53A 4oguA-4rxeA:
42.8		 4oguA-4rxeA:
38.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P0V_A_ZOLA401_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 9 ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
THR A 213
GLN A 252
ASP A 255
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
 0.33A 4p0vA-4rxeA:
44.1		 4p0vA-4rxeA:
37.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P0V_A_ZOLA401_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 9 ASP A 103
ASP A 107
GLN A 172
LYS A 212
THR A 213
GLN A 252
ASP A 255
LYS A 269
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 0.72A 4p0vA-4rxeA:
44.1		 4p0vA-4rxeA:
37.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		9 / 11 ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
THR A 213
TYR A 216
GLN A 252
ASP A 255
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 (-4.7A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
 0.35A 4p0wA-4rxeA:
44.1		 4p0wA-4rxeA:
35.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 11 ASP A 103
ASP A 107
GLN A 172
LYS A 212
THR A 213
GLN A 252
ASP A 255
LYS A 269
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 0.72A 4p0wA-4rxeA:
44.1		 4p0wA-4rxeA:
35.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 11 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
TYR A 216
ASP A 255
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.7A)
MG  A3003 ( 2.9A)
 0.54A 4p0wA-4rxeA:
44.1		 4p0wA-4rxeA:
35.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		4 / 5 THR A 167
THR A 168
THR A 140
HIS A 141
 None
 1.35A 4pgfB-4rxeA:
undetectable		 4pgfB-4rxeA:
19.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q23_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 10 ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
TYR A 216
GLN A 252
ASP A 255
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.7A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
 0.29A 4q23A-4rxeA:
42.8		 4q23A-4rxeA:
38.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q23_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		7 / 10 ASP A 103
ASP A 107
GLN A 172
LYS A 212
GLN A 252
ASP A 255
LYS A 269
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 0.80A 4q23A-4rxeA:
42.8		 4q23A-4rxeA:
38.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q23_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 10 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
TYR A 216
ASP A 255
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.7A)
MG  A3003 ( 2.9A)
 0.51A 4q23A-4rxeA:
42.8		 4q23A-4rxeA:
38.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		9 / 10 ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
THR A 213
GLN A 252
ASP A 255
LYS A 269
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 0.66A 4rxdA-4rxeA:
54.8		 4rxdA-4rxeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 10 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
ASP A 255
LYS A 269
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 0.81A 4rxdA-4rxeA:
54.8		 4rxdA-4rxeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 10 LEU A 100
ASP A 103
ASP A 107
ARG A 112
THR A 168
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
None
 1.17A 4rxdA-4rxeA:
54.8		 4rxdA-4rxeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		9 / 10 ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
THR A 213
GLN A 252
ASP A 255
LYS A 269
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 0.67A 4rxdB-4rxeA:
55.3		 4rxdB-4rxeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		9 / 10 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
GLN A 252
ASP A 255
LYS A 269
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 0.79A 4rxdB-4rxeA:
55.3		 4rxdB-4rxeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 10 LEU A 100
ASP A 103
ASP A 107
ARG A 112
THR A 168
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
None
 1.17A 4rxdB-4rxeA:
55.3		 4rxdB-4rxeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		9 / 10 ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
THR A 213
GLN A 252
ASP A 255
LYS A 269
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 0.68A 4rxdC-4rxeA:
55.4		 4rxdC-4rxeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 10 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
ASP A 255
LYS A 269
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 0.83A 4rxdC-4rxeA:
55.4		 4rxdC-4rxeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 10 LEU A 100
ASP A 103
ASP A 107
ARG A 112
THR A 168
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
None
 1.17A 4rxdC-4rxeA:
55.4		 4rxdC-4rxeA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		6 / 8 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
 0.75A 4umjA-4rxeA:
23.5		 4umjA-4rxeA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		7 / 9 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
THR A 213
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
 0.68A 4umjB-4rxeA:
23.6		 4umjB-4rxeA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 9 LEU A 100
ASP A 103
ASP A 107
ARG A 112
THR A 168
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
None
 1.16A 4umjB-4rxeA:
23.6		 4umjB-4rxeA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 12 VAL A 126
GLU A 102
GLY A 133
TYR A 119
SER A 138
 None
 1.31A 4xudA-4rxeA:
undetectable		 4xudA-4rxeA:
20.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		10 / 12 ASP A 103
ASP A 107
ARG A 112
THR A 168
GLN A 172
LYS A 212
THR A 213
TYR A 216
GLN A 252
ASP A 255
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
None
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 (-4.7A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
 0.25A 5cg5A-4rxeA:
43.5		 5cg5A-4rxeA:
36.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		10 / 12 ASP A 103
ASP A 107
THR A 168
GLN A 172
LYS A 212
THR A 213
TYR A 216
GLN A 252
ASP A 255
LYS A 269
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
None
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 (-4.7A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 0.57A 5cg5A-4rxeA:
43.5		 5cg5A-4rxeA:
36.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		9 / 12 LEU A 100
ASP A 103
ASP A 107
ARG A 112
THR A 168
GLN A 172
LYS A 212
TYR A 216
ASP A 255
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
None
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.7A)
MG  A3003 ( 2.9A)
 0.49A 5cg5A-4rxeA:
43.5		 5cg5A-4rxeA:
36.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		9 / 12 LEU A 100
ASP A 103
ASP A 107
THR A 168
GLN A 172
LYS A 212
TYR A 216
ASP A 255
LYS A 269
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
None
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.7A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 0.73A 5cg5A-4rxeA:
43.5		 5cg5A-4rxeA:
36.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		9 / 12 ASP A 103
ASP A 107
ARG A 112
THR A 168
GLN A 172
LYS A 212
THR A 213
GLN A 252
ASP A 255
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
None
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
 0.29A 5cg6A-4rxeA:
44.0		 5cg6A-4rxeA:
36.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		9 / 12 ASP A 103
ASP A 107
THR A 168
GLN A 172
LYS A 212
THR A 213
GLN A 252
ASP A 255
LYS A 269
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
None
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 0.72A 5cg6A-4rxeA:
44.0		 5cg6A-4rxeA:
36.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 12 LEU A 100
ASP A 103
ASP A 107
ARG A 112
THR A 168
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
None
 1.19A 5cg6A-4rxeA:
44.0		 5cg6A-4rxeA:
36.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		9 / 12 LEU A 100
ASP A 103
ASP A 107
ARG A 112
THR A 168
GLN A 172
LYS A 212
THR A 213
ASP A 255
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
None
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
MG  A3003 ( 2.9A)
 0.50A 5cg6A-4rxeA:
44.0		 5cg6A-4rxeA:
36.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_A_210A804_1
(FUSICOCCADIENE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 9 LEU A 100
ASP A 103
ASP A 107
ARG A 112
LYS A 212
GLN A 252
ASP A 255
LYS A 269
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 0.86A 5eroA-4rxeA:
27.3		 5eroA-4rxeA:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_B_210B804_1
(FUSICOCCADIENE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		8 / 9 ASP A 103
ASP A 107
ARG A 112
LYS A 212
GLN A 252
ASP A 255
ASP A 256
LYS A 269
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
None
3YQ  A3001 (-3.1A)
 0.80A 5eroB-4rxeA:
27.0		 5eroB-4rxeA:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_B_210B804_1
(FUSICOCCADIENE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 9 ASP A 107
GLN A 252
ASP A 255
ASP A 256
LYS A 269
 MG  A3004 (-2.3A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
None
3YQ  A3001 (-3.1A)
 1.27A 5eroB-4rxeA:
27.0		 5eroB-4rxeA:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		9 / 10 ASP A 103
ASP A 104
ASP A 107
ARG A 112
LYS A 212
GLN A 252
ASP A 255
ASP A 256
LYS A 269
 MG  A3004 (-2.5A)
MG  A3002 (-4.6A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
None
3YQ  A3001 (-3.1A)
 0.72A 5eroC-4rxeA:
27.0		 5eroC-4rxeA:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		7 / 10 ASP A 107
ASP A 104
ARG A 112
GLN A 252
ASP A 255
ASP A 256
LYS A 269
 MG  A3004 (-2.3A)
MG  A3002 (-4.6A)
3YQ  A3001 (-2.8A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
None
3YQ  A3001 (-3.1A)
 1.24A 5eroC-4rxeA:
27.0		 5eroC-4rxeA:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		4 / 6 VAL A 355
ILE A 341
GLU A 342
ARG A 345
 None
 0.97A 5z3jA-4rxeA:
undetectable		 5z3jA-4rxeA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		4 / 6 CYH A  88
ILE A  92
ILE A 227
ASP A 156
 None
 1.20A 6cbdA-4rxeA:
undetectable		 6cbdA-4rxeA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_A_ACTA403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		3 / 3 TYR A  99
ASP A 103
GLN A 172
 None
MG  A3004 (-2.5A)
MG  A3004 ( 3.8A)
 0.93A 6g1pA-4rxeA:
undetectable		 6g1pA-4rxeA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_A_ZOLA401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		6 / 7 ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
GLN A 252
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 ( 4.2A)
 0.97A 6g31A-4rxeA:
25.7		 6g31A-4rxeA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_B_ZOLB401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 6 ASP A 103
ASP A 107
ARG A 112
GLN A 172
GLN A 252
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 ( 4.2A)
 0.66A 6g31B-4rxeA:
25.8		 6g31B-4rxeA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_C_ZOLC401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 5 ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
 1.22A 6g31C-4rxeA:
25.9		 6g31C-4rxeA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		6 / 7 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 172
GLN A 252
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 ( 4.2A)
 0.74A 6g31D-4rxeA:
25.3		 6g31D-4rxeA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_E_ZOLE401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		4 / 4 LEU A 100
ASP A 103
ASP A 107
ARG A 112
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
 0.66A 6g31E-4rxeA:
19.8		 6g31E-4rxeA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_F_ZOLF401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 5 ASP A 103
ASP A 107
ARG A 112
GLN A 172
GLN A 252
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 ( 4.2A)
 0.58A 6g31F-4rxeA:
25.8		 6g31F-4rxeA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		6 / 7 ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
GLN A 252
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 ( 4.2A)
 0.49A 6g31G-4rxeA:
24.9		 6g31G-4rxeA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_H_ZOLH401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		4 / 5 ASP A 103
ASP A 107
GLN A 172
GLN A 252
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
MG  A3004 ( 3.8A)
3YQ  A3001 ( 4.2A)
 0.46A 6g31H-4rxeA:
24.6		 6g31H-4rxeA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_I_ZOLI401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		4 / 4 ASP A 103
ASP A 107
LYS A 212
GLN A 252
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.9A)
3YQ  A3001 ( 4.2A)
 0.91A 6g31I-4rxeA:
24.8		 6g31I-4rxeA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		6 / 6 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 172
GLN A 252
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 ( 4.2A)
 1.01A 6g31J-4rxeA:
26.1		 6g31J-4rxeA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_K_ZOLK401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		4 / 4 ASP A 103
ASP A 107
ARG A 112
GLN A 172
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
 0.49A 6g31K-4rxeA:
23.7		 6g31K-4rxeA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_L_ZOLL401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 6 ASP A 103
ASP A 107
ARG A 112
GLN A 172
GLN A 252
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 ( 4.2A)
 0.83A 6g31L-4rxeA:
25.6		 6g31L-4rxeA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_L_ZOLL401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
brucei) 		5 / 6 ASP A 103
ASP A 107
GLN A 172
GLN A 252
LYS A 278
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
MG  A3004 ( 3.8A)
3YQ  A3001 ( 4.2A)
None
 1.30A 6g31L-4rxeA:
25.6		 6g31L-4rxeA:
11.14