SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rxl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_A_803A311_1
(ANTIGEN CD11A (P180))
4rxl MOLYBDENUM ABC
TRANSPORTER,
PERIPLASMIC
MOLYBDENUM-BINDING
PROTEIN

(Vibrio
cholerae)
6 / 10 LEU A 108
ILE A 189
LEU A 167
GLU A 164
LEU A 163
VAL A 159
None
1.24A 1cqpA-4rxlA:
undetectable
1cqpB-4rxlA:
undetectable
1cqpA-4rxlA:
18.33
1cqpB-4rxlA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)
4rxl MOLYBDENUM ABC
TRANSPORTER,
PERIPLASMIC
MOLYBDENUM-BINDING
PROTEIN

(Vibrio
cholerae)
5 / 12 ALA A  30
TYR A  57
LEU A 101
VAL A  42
LEU A  41
None
1.05A 1jipA-4rxlA:
undetectable
1jipA-4rxlA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)
4rxl MOLYBDENUM ABC
TRANSPORTER,
PERIPLASMIC
MOLYBDENUM-BINDING
PROTEIN

(Vibrio
cholerae)
4 / 6 LEU A 187
TRP A 127
LEU A 121
PHE A 207
None
1.45A 1ru9H-4rxlA:
undetectable
1ru9L-4rxlA:
undetectable
1ru9H-4rxlA:
23.88
1ru9L-4rxlA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
4rxl MOLYBDENUM ABC
TRANSPORTER,
PERIPLASMIC
MOLYBDENUM-BINDING
PROTEIN

(Vibrio
cholerae)
3 / 3 ASN A  80
TRP A  83
GLN A 152
None
1.30A 1xoqA-4rxlA:
undetectable
1xoqA-4rxlA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)
4rxl MOLYBDENUM ABC
TRANSPORTER,
PERIPLASMIC
MOLYBDENUM-BINDING
PROTEIN

(Vibrio
cholerae)
4 / 8 PHE A 119
LEU A 108
LEU A 154
LEU A 163
None
0.89A 2bfpA-4rxlA:
undetectable
2bfpA-4rxlA:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)
4rxl MOLYBDENUM ABC
TRANSPORTER,
PERIPLASMIC
MOLYBDENUM-BINDING
PROTEIN

(Vibrio
cholerae)
5 / 11 ALA A 150
LEU A 131
LEU A 187
LEU A 136
ARG A 166
None
1.04A 2ceoA-4rxlA:
undetectable
2ceoA-4rxlA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
4rxl MOLYBDENUM ABC
TRANSPORTER,
PERIPLASMIC
MOLYBDENUM-BINDING
PROTEIN

(Vibrio
cholerae)
4 / 6 PHE A 207
VAL A 159
LEU A 163
ALA A 150
None
1.08A 2e1qA-4rxlA:
undetectable
2e1qA-4rxlA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
4rxl MOLYBDENUM ABC
TRANSPORTER,
PERIPLASMIC
MOLYBDENUM-BINDING
PROTEIN

(Vibrio
cholerae)
4 / 6 PHE A 207
VAL A 159
LEU A 163
ALA A 150
None
1.06A 2e1qC-4rxlA:
undetectable
2e1qC-4rxlA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)
4rxl MOLYBDENUM ABC
TRANSPORTER,
PERIPLASMIC
MOLYBDENUM-BINDING
PROTEIN

(Vibrio
cholerae)
5 / 10 ALA A 150
LEU A 131
LEU A 187
LEU A 136
ARG A 166
None
1.10A 2riwA-4rxlA:
undetectable
2riwB-4rxlA:
undetectable
2riwA-4rxlA:
22.41
2riwB-4rxlA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)
4rxl MOLYBDENUM ABC
TRANSPORTER,
PERIPLASMIC
MOLYBDENUM-BINDING
PROTEIN

(Vibrio
cholerae)
5 / 10 ALA A 150
LEU A 131
LEU A 154
LEU A 136
ARG A 166
None
1.14A 2xn6A-4rxlA:
undetectable
2xn6B-4rxlA:
undetectable
2xn6A-4rxlA:
22.07
2xn6B-4rxlA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)
4rxl MOLYBDENUM ABC
TRANSPORTER,
PERIPLASMIC
MOLYBDENUM-BINDING
PROTEIN

(Vibrio
cholerae)
5 / 10 ALA A 150
LEU A 131
LEU A 187
LEU A 136
ARG A 166
None
1.07A 2xn6A-4rxlA:
undetectable
2xn6B-4rxlA:
undetectable
2xn6A-4rxlA:
22.07
2xn6B-4rxlA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)
4rxl MOLYBDENUM ABC
TRANSPORTER,
PERIPLASMIC
MOLYBDENUM-BINDING
PROTEIN

(Vibrio
cholerae)
5 / 10 ALA A 150
LEU A 131
LEU A 187
LEU A 136
ARG A 166
None
1.08A 2xn7A-4rxlA:
undetectable
2xn7B-4rxlA:
undetectable
2xn7A-4rxlA:
22.07
2xn7B-4rxlA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)
4rxl MOLYBDENUM ABC
TRANSPORTER,
PERIPLASMIC
MOLYBDENUM-BINDING
PROTEIN

(Vibrio
cholerae)
4 / 5 ALA A 239
GLN A 242
ILE A 243
ARG A 246
None
0.49A 2z0aA-4rxlA:
undetectable
2z0aA-4rxlA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_A_DP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)
4rxl MOLYBDENUM ABC
TRANSPORTER,
PERIPLASMIC
MOLYBDENUM-BINDING
PROTEIN

(Vibrio
cholerae)
5 / 12 TYR A 191
ILE A 215
GLU A 250
ALA A  37
SER A  33
WO4  A 301 (-4.5A)
None
None
None
WO4  A 301 (-2.4A)
1.39A 3apwA-4rxlA:
undetectable
3apwA-4rxlA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)
4rxl MOLYBDENUM ABC
TRANSPORTER,
PERIPLASMIC
MOLYBDENUM-BINDING
PROTEIN

(Vibrio
cholerae)
4 / 5 LEU A 179
GLN A 169
THR A 170
LEU A 131
None
1.13A 3ce6D-4rxlA:
undetectable
3ce6D-4rxlA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
4rxl MOLYBDENUM ABC
TRANSPORTER,
PERIPLASMIC
MOLYBDENUM-BINDING
PROTEIN

(Vibrio
cholerae)
5 / 12 VAL A  88
ILE A  28
ASP A  74
LEU A 219
LEU A 235
None
1.16A 3cjtG-4rxlA:
undetectable
3cjtG-4rxlA:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_K_SAMK302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
4rxl MOLYBDENUM ABC
TRANSPORTER,
PERIPLASMIC
MOLYBDENUM-BINDING
PROTEIN

(Vibrio
cholerae)
5 / 12 VAL A  88
ILE A  28
ASP A  74
LEU A 219
LEU A 235
None
1.16A 3cjtK-4rxlA:
undetectable
3cjtK-4rxlA:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)
4rxl MOLYBDENUM ABC
TRANSPORTER,
PERIPLASMIC
MOLYBDENUM-BINDING
PROTEIN

(Vibrio
cholerae)
5 / 12 GLY A 248
SER A 105
LEU A 196
SER A  33
ALA A 195
None
None
None
WO4  A 301 (-2.4A)
None
1.23A 3d91A-4rxlA:
undetectable
3d91A-4rxlA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)
4rxl MOLYBDENUM ABC
TRANSPORTER,
PERIPLASMIC
MOLYBDENUM-BINDING
PROTEIN

(Vibrio
cholerae)
5 / 12 ALA A 130
LEU A 121
GLN A 122
ILE A 189
LEU A 154
None
1.45A 3ia4A-4rxlA:
2.4
3ia4A-4rxlA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)
4rxl MOLYBDENUM ABC
TRANSPORTER,
PERIPLASMIC
MOLYBDENUM-BINDING
PROTEIN

(Vibrio
cholerae)
4 / 8 ALA A  31
SER A  78
TYR A 149
TYR A 217
WO4  A 301 (-3.3A)
None
None
None
1.16A 4ijiF-4rxlA:
undetectable
4ijiF-4rxlA:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)
4rxl MOLYBDENUM ABC
TRANSPORTER,
PERIPLASMIC
MOLYBDENUM-BINDING
PROTEIN

(Vibrio
cholerae)
5 / 12 ILE A 215
HIS A 212
ILE A 189
ALA A 153
PHE A 207
None
1.24A 4rp8C-4rxlA:
undetectable
4rp8C-4rxlA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)
4rxl MOLYBDENUM ABC
TRANSPORTER,
PERIPLASMIC
MOLYBDENUM-BINDING
PROTEIN

(Vibrio
cholerae)
5 / 9 ALA A 150
LEU A 131
LEU A 154
LEU A 136
ARG A 166
None
1.17A 4x30A-4rxlA:
undetectable
4x30A-4rxlA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)
4rxl MOLYBDENUM ABC
TRANSPORTER,
PERIPLASMIC
MOLYBDENUM-BINDING
PROTEIN

(Vibrio
cholerae)
4 / 8 SER A 105
ALA A 195
LEU A 196
GLY A 248
None
0.86A 4xk8a-4rxlA:
undetectable
4xk8a-4rxlA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)
4rxl MOLYBDENUM ABC
TRANSPORTER,
PERIPLASMIC
MOLYBDENUM-BINDING
PROTEIN

(Vibrio
cholerae)
5 / 12 ALA A 126
PHE A 119
GLN A 114
ARG A 166
LEU A 187
None
1.28A 5m54B-4rxlA:
undetectable
5m54B-4rxlA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4rxl MOLYBDENUM ABC
TRANSPORTER,
PERIPLASMIC
MOLYBDENUM-BINDING
PROTEIN

(Vibrio
cholerae)
4 / 6 GLN A 128
PHE A 119
LEU A 121
PHE A 207
None
1.10A 5zcoP-4rxlA:
undetectable
5zcoW-4rxlA:
undetectable
5zcoP-4rxlA:
20.55
5zcoW-4rxlA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4rxl MOLYBDENUM ABC
TRANSPORTER,
PERIPLASMIC
MOLYBDENUM-BINDING
PROTEIN

(Vibrio
cholerae)
4 / 6 GLN A 128
PHE A 119
LEU A 121
PHE A 207
None
1.10A 5zcpC-4rxlA:
undetectable
5zcpJ-4rxlA:
undetectable
5zcpC-4rxlA:
20.55
5zcpJ-4rxlA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)
4rxl MOLYBDENUM ABC
TRANSPORTER,
PERIPLASMIC
MOLYBDENUM-BINDING
PROTEIN

(Vibrio
cholerae)
5 / 12 ILE A 109
TYR A 191
GLY A 147
ALA A 150
LEU A 154
None
WO4  A 301 (-4.5A)
None
None
None
1.08A 5zwrA-4rxlA:
undetectable
5zwrA-4rxlA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)
4rxl MOLYBDENUM ABC
TRANSPORTER,
PERIPLASMIC
MOLYBDENUM-BINDING
PROTEIN

(Vibrio
cholerae)
4 / 8 GLU A  82
ARG A 216
PRO A 218
PRO A 145
None
None
None
WO4  A 301 (-3.6A)
0.88A 6a4iA-4rxlA:
undetectable
6a4iA-4rxlA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)
4rxl MOLYBDENUM ABC
TRANSPORTER,
PERIPLASMIC
MOLYBDENUM-BINDING
PROTEIN

(Vibrio
cholerae)
4 / 7 GLU A  82
ARG A 216
PRO A 218
PRO A 145
None
None
None
WO4  A 301 (-3.6A)
1.21A 6a4iB-4rxlA:
undetectable
6a4iB-4rxlA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)
4rxl MOLYBDENUM ABC
TRANSPORTER,
PERIPLASMIC
MOLYBDENUM-BINDING
PROTEIN

(Vibrio
cholerae)
5 / 12 THR A  35
LEU A 175
GLY A  58
PHE A 249
VAL A 190
None
1.03A 6a94B-4rxlA:
undetectable
6a94B-4rxlA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)
4rxl MOLYBDENUM ABC
TRANSPORTER,
PERIPLASMIC
MOLYBDENUM-BINDING
PROTEIN

(Vibrio
cholerae)
5 / 9 ALA A  31
SER A  33
SER A  60
GLY A  58
ALA A 139
WO4  A 301 (-3.3A)
WO4  A 301 (-2.4A)
WO4  A 301 (-2.3A)
None
WO4  A 301 ( 4.9A)
0.97A 6bklE-4rxlA:
undetectable
6bklF-4rxlA:
undetectable
6bklG-4rxlA:
undetectable
6bklH-4rxlA:
undetectable
6bklE-4rxlA:
7.89
6bklF-4rxlA:
7.89
6bklG-4rxlA:
7.89
6bklH-4rxlA:
7.89