SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rxm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_B_FK5B401_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica)
5 / 10 ASP A 184
ARG A 169
VAL A 211
ILE A 212
ILE A 197
None
1.34A 1q6iB-4rxmA:
undetectable
1q6iB-4rxmA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_C_T44C601_1
(TRANSTHYRETIN)
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica)
5 / 9 LEU A 259
LEU A 297
LYS A 137
GLU A 171
ALA A 138
None
1.45A 1sn0A-4rxmA:
undetectable
1sn0C-4rxmA:
undetectable
1sn0A-4rxmA:
18.49
1sn0C-4rxmA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica)
5 / 8 LEU A  31
GLN A  69
PHE A  29
LEU A  42
PHE A  38
None
None
None
None
INS  A 401 (-4.5A)
1.15A 1v54C-4rxmA:
undetectable
1v54J-4rxmA:
undetectable
1v54C-4rxmA:
20.81
1v54J-4rxmA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica)
4 / 8 LEU A  31
PHE A  29
LEU A  42
PHE A  38
None
None
None
INS  A 401 (-4.5A)
0.91A 1v54P-4rxmA:
undetectable
1v54W-4rxmA:
undetectable
1v54P-4rxmA:
20.81
1v54W-4rxmA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica)
5 / 8 LEU A  31
GLN A  69
PHE A  29
LEU A  42
PHE A  38
None
None
None
None
INS  A 401 (-4.5A)
1.16A 2dyrC-4rxmA:
undetectable
2dyrJ-4rxmA:
undetectable
2dyrC-4rxmA:
20.81
2dyrJ-4rxmA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica)
4 / 7 LEU A  31
PHE A  29
LEU A  42
PHE A  38
None
None
None
INS  A 401 (-4.5A)
0.96A 2eimP-4rxmA:
undetectable
2eimW-4rxmA:
undetectable
2eimP-4rxmA:
20.81
2eimW-4rxmA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica)
4 / 6 THR A 159
PRO A  88
SER A  95
VAL A  98
None
1.05A 2hdnI-4rxmA:
undetectable
2hdnJ-4rxmA:
3.0
2hdnL-4rxmA:
2.5
2hdnI-4rxmA:
8.75
2hdnJ-4rxmA:
22.16
2hdnL-4rxmA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica)
4 / 6 SER A  95
VAL A  98
THR A 159
PRO A  88
None
1.09A 2hdnJ-4rxmA:
3.0
2hdnK-4rxmA:
undetectable
2hdnL-4rxmA:
2.5
2hdnJ-4rxmA:
22.16
2hdnK-4rxmA:
8.75
2hdnL-4rxmA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica)
4 / 6 LEU A  31
GLN A  69
LEU A  42
PHE A  38
None
None
None
INS  A 401 (-4.5A)
1.02A 2zxwP-4rxmA:
undetectable
2zxwW-4rxmA:
undetectable
2zxwP-4rxmA:
20.81
2zxwW-4rxmA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica)
4 / 6 LEU A  31
GLN A  69
LEU A  42
PHE A  38
None
None
None
INS  A 401 (-4.5A)
1.01A 3ag1C-4rxmA:
undetectable
3ag1J-4rxmA:
undetectable
3ag1C-4rxmA:
20.81
3ag1J-4rxmA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica)
4 / 7 LEU A  31
PHE A  29
LEU A  42
PHE A  38
None
None
None
INS  A 401 (-4.5A)
0.97A 3asnC-4rxmA:
undetectable
3asnJ-4rxmA:
undetectable
3asnC-4rxmA:
20.81
3asnJ-4rxmA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica)
4 / 7 LEU A  31
PHE A  29
LEU A  42
PHE A  38
None
None
None
INS  A 401 (-4.5A)
0.92A 3asnP-4rxmA:
undetectable
3asnW-4rxmA:
undetectable
3asnP-4rxmA:
20.81
3asnW-4rxmA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica)
4 / 7 LEU A  31
PHE A  29
LEU A  42
PHE A  38
None
None
None
INS  A 401 (-4.5A)
0.93A 3asoP-4rxmA:
undetectable
3asoW-4rxmA:
undetectable
3asoP-4rxmA:
20.81
3asoW-4rxmA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica)
5 / 12 ALA A 268
LEU A 111
PRO A  32
ASN A  33
LEU A  34
None
1.38A 3eigA-4rxmA:
undetectable
3eigA-4rxmA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_B_TRUB800_1
(GLUTAMATE RECEPTOR 2)
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica)
5 / 12 PRO A  32
SER A  64
LEU A  42
LEU A  34
SER A  36
None
None
None
None
INS  A 401 ( 4.4A)
1.36A 3iltB-4rxmA:
2.1
3iltE-4rxmA:
3.4
3iltB-4rxmA:
21.81
3iltE-4rxmA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P73_A_ACTA275_0
(MHC RFP-Y CLASS I
ALPHA CHAIN)
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica)
3 / 3 ILE A  55
VAL A 277
ARG A 281
None
0.62A 3p73A-4rxmA:
undetectable
3p73A-4rxmA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQA_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica)
5 / 10 ASP A 184
ARG A 169
VAL A 211
ILE A 212
ILE A 197
None
1.42A 3uqaA-4rxmA:
undetectable
3uqaA-4rxmA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_C_MIYC2001_1
(TETX2 PROTEIN)
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica)
4 / 8 PHE A 242
GLY A 241
GLY A 167
ASN A 127
None
1.01A 3v3nC-4rxmA:
undetectable
3v3nC-4rxmA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica)
4 / 6 LEU A  31
PHE A  29
LEU A  42
PHE A  38
None
None
None
INS  A 401 (-4.5A)
0.96A 3wg7C-4rxmA:
undetectable
3wg7J-4rxmA:
undetectable
3wg7C-4rxmA:
20.81
3wg7J-4rxmA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica)
4 / 6 LEU A  31
PHE A  29
LEU A  42
PHE A  38
None
None
None
INS  A 401 (-4.5A)
0.99A 3wg7P-4rxmA:
undetectable
3wg7W-4rxmA:
undetectable
3wg7P-4rxmA:
20.81
3wg7W-4rxmA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica)
4 / 8 ILE A 213
ARG A 191
LEU A 151
ILE A 212
None
0.75A 4v04A-4rxmA:
undetectable
4v04A-4rxmA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y9T_A_PA1A401_1
(ABC TRANSPORTER,
SOLUTE BINDING
PROTEIN)
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica)
5 / 12 PHE A  38
ASP A 112
ARG A 113
TRP A 189
GLN A 263
INS  A 401 (-4.5A)
INS  A 401 (-2.6A)
INS  A 401 (-3.8A)
INS  A 401 (-3.6A)
INS  A 401 (-3.3A)
0.80A 4y9tA-4rxmA:
35.5
4y9tA-4rxmA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica)
5 / 7 LEU A  31
GLN A  69
PHE A  29
LEU A  42
PHE A  38
None
None
None
None
INS  A 401 (-4.5A)
1.11A 5b1bP-4rxmA:
undetectable
5b1bW-4rxmA:
undetectable
5b1bP-4rxmA:
20.81
5b1bW-4rxmA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BR1_A_X6XA401_1
(ABC TRANSPORTER,
BINDING PROTEIN)
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica)
5 / 11 PHE A  38
ASP A 112
ARG A 113
TRP A 189
GLN A 263
INS  A 401 (-4.5A)
INS  A 401 (-2.6A)
INS  A 401 (-3.8A)
INS  A 401 (-3.6A)
INS  A 401 (-3.3A)
0.78A 5br1A-4rxmA:
35.4
5br1A-4rxmA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica)
5 / 10 LEU A 111
GLY A 288
VAL A 276
LEU A 273
THR A 271
None
1.02A 5o96G-4rxmA:
undetectable
5o96H-4rxmA:
2.9
5o96G-4rxmA:
21.07
5o96H-4rxmA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica)
5 / 12 GLY A 154
VAL A 139
LEU A 259
GLY A 132
ILE A 168
None
0.77A 5vooA-4rxmA:
2.6
5vooA-4rxmA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica)
5 / 12 GLY A 154
VAL A 139
LEU A 259
GLY A 132
ILE A 168
None
0.77A 5vooB-4rxmA:
2.3
5vooB-4rxmA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica)
5 / 12 GLY A 154
VAL A 139
LEU A 259
GLY A 132
ILE A 168
None
0.80A 5vooC-4rxmA:
2.3
5vooC-4rxmA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica)
5 / 12 GLY A 154
VAL A 139
LEU A 259
GLY A 132
ILE A 168
None
0.78A 5vooD-4rxmA:
undetectable
5vooD-4rxmA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica)
5 / 12 GLY A 154
VAL A 139
LEU A 259
GLY A 132
ILE A 168
None
0.84A 5vooE-4rxmA:
undetectable
5vooE-4rxmA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica)
5 / 12 GLY A 154
VAL A 139
LEU A 259
GLY A 132
ILE A 168
None
0.84A 5vooF-4rxmA:
2.6
5vooF-4rxmA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica)
5 / 12 GLY A 154
VAL A 139
LEU A 259
GLY A 132
ILE A 168
None
0.77A 5vopA-4rxmA:
2.6
5vopA-4rxmA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica)
5 / 12 GLY A 154
VAL A 139
LEU A 259
GLY A 132
ILE A 168
None
0.90A 5vopB-4rxmA:
undetectable
5vopB-4rxmA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica)
4 / 5 LEU A  31
PHE A  29
LEU A  42
PHE A  38
None
None
None
INS  A 401 (-4.5A)
0.98A 5x19C-4rxmA:
undetectable
5x19J-4rxmA:
undetectable
5x19C-4rxmA:
20.81
5x19J-4rxmA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica)
4 / 7 LEU A  31
PHE A  29
LEU A  42
PHE A  38
None
None
None
INS  A 401 (-4.5A)
0.97A 5x1fP-4rxmA:
undetectable
5x1fW-4rxmA:
undetectable
5x1fP-4rxmA:
20.81
5x1fW-4rxmA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica)
4 / 7 LEU A  31
PHE A  29
LEU A  42
PHE A  38
None
None
None
INS  A 401 (-4.5A)
0.93A 5zcoC-4rxmA:
undetectable
5zcoJ-4rxmA:
undetectable
5zcoC-4rxmA:
20.81
5zcoJ-4rxmA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica)
4 / 7 LEU A  31
PHE A  29
LEU A  42
PHE A  38
None
None
None
INS  A 401 (-4.5A)
0.95A 5zcqC-4rxmA:
undetectable
5zcqJ-4rxmA:
undetectable
5zcqC-4rxmA:
20.81
5zcqJ-4rxmA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica)
5 / 10 HIS A 123
ALA A 109
PRO A  32
PHE A  38
VAL A 269
None
None
None
INS  A 401 (-4.5A)
None
0.99A 6b89B-4rxmA:
2.5
6b89B-4rxmA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica)
4 / 7 LEU A 232
GLY A 235
LEU A 257
GLY A 241
None
0.79A 6eu9D-4rxmA:
undetectable
6eu9D-4rxmA:
15.86