SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rxt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4rxt SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		5 / 11 ASP A 123
GLY A 142
THR A 140
GLY A 175
GLN A 179
 ARA  A 401 (-2.7A)
None
None
None
None
 1.44A 1jr1A-4rxtA:
undetectable		 1jr1A-4rxtA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4rxt SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		5 / 11 ASP A 123
GLY A 143
THR A 140
GLY A 175
GLN A 179
 ARA  A 401 (-2.7A)
None
None
None
None
 1.40A 1jr1A-4rxtA:
undetectable		 1jr1A-4rxtA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_1
(PROTEASE)		 4rxt SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		5 / 10 GLY A 269
ALA A 270
GLY A 255
ILE A 254
ILE A 242
 None
 0.98A 1muiA-4rxtA:
undetectable		 1muiA-4rxtA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		 4rxt SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		3 / 3 ASN A 212
ALA A 241
ASN A 245
 None
 0.83A 1n4fA-4rxtA:
undetectable		 1n4fA-4rxtA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 4rxt SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		5 / 9 ASN A 231
ILE A 233
ALA A 207
GLN A 236
THR A 262
 ARA  A 401 (-3.7A)
None
None
None
None
 1.39A 2dtjA-4rxtA:
undetectable
2dtjB-4rxtA:
undetectable		 2dtjA-4rxtA:
21.90
2dtjB-4rxtA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 4rxt SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		5 / 9 ALA A 229
ALA A 203
GLY A 205
GLY A 210
ILE A 213
 None
 0.86A 2v7bA-4rxtA:
4.6		 2v7bA-4rxtA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 4rxt SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		5 / 9 ALA A 229
ALA A 203
GLY A 205
GLY A 210
ILE A 213
 None
 0.87A 2v7bB-4rxtA:
4.2		 2v7bB-4rxtA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 4rxt SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		4 / 5 GLN A 236
ALA A 207
GLN A 206
ILE A 233
 None
 1.34A 2z0aA-4rxtA:
undetectable		 2z0aA-4rxtA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		 4rxt SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		5 / 12 GLY A 142
GLY A 143
GLN A 141
MET A 282
ILE A 254
 None
 1.13A 3h52B-4rxtA:
undetectable		 3h52B-4rxtA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 4rxt SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		5 / 10 LYS A 201
SER A 230
LEU A 217
ILE A 213
GLY A 210
 None
 1.41A 3ijxB-4rxtA:
2.5
3ijxD-4rxtA:
2.5		 3ijxB-4rxtA:
25.39
3ijxD-4rxtA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 4rxt SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		5 / 10 ILE A 213
GLY A 210
LYS A 201
SER A 230
LEU A 217
 None
 1.42A 3ik6B-4rxtA:
3.5
3ik6E-4rxtA:
3.3		 3ik6B-4rxtA:
25.39
3ik6E-4rxtA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 4rxt SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		5 / 10 LYS A 201
SER A 230
LEU A 217
ILE A 213
GLY A 210
 None
 1.44A 3iluB-4rxtA:
undetectable
3iluE-4rxtA:
2.9		 3iluB-4rxtA:
25.39
3iluE-4rxtA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB830_1
(ALPHA-AMYLASE, SUSG)		 4rxt SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		4 / 5 ARG A 281
TYR A 284
LYS A 288
ASP A 285
 None
 1.16A 3k8mB-4rxtA:
0.7		 3k8mB-4rxtA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 4rxt SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		5 / 10 PRO A 172
ARG A 180
GLY A 205
GLY A 175
ALA A 174
 None
ARA  A 401 (-3.0A)
None
None
None
 1.50A 3pp7B-4rxtA:
3.7		 3pp7B-4rxtA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROZ_A_NCAA266_0
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 4rxt SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		4 / 6 ASP A 216
LEU A 217
ALA A 241
LEU A 211
 None
 1.00A 3rozA-4rxtA:
4.6		 3rozA-4rxtA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4rxt SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		5 / 9 LEU A  63
LEU A  70
ILE A  40
TYR A 284
ILE A  96
 None
 1.21A 3zosB-4rxtA:
undetectable		 3zosB-4rxtA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 4rxt SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		5 / 12 LEU A  63
ILE A  39
VAL A  67
ALA A 292
ASP A 285
 None
 1.14A 4a6dA-4rxtA:
3.2		 4a6dA-4rxtA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4rxt SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		5 / 12 VAL A  65
GLY A 286
ILE A  37
ILE A  39
ARG A 281
 None
 0.97A 4iv0A-4rxtA:
undetectable		 4iv0A-4rxtA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4rxt SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		5 / 10 THR A 215
LEU A 211
GLY A 237
VAL A 227
VAL A 253
 None
 1.18A 4jx1B-4rxtA:
undetectable		 4jx1B-4rxtA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4rxt SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		5 / 12 VAL A  65
GLY A 286
ILE A  37
ILE A  39
ARG A 281
 None
 0.98A 4mwzB-4rxtA:
undetectable		 4mwzB-4rxtA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA602_1
(SERUM ALBUMIN)		 4rxt SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		5 / 9 ALA A 235
ALA A 229
LEU A 177
LEU A 274
VAL A 275
 None
None
ARA  A 401 ( 4.6A)
None
None
 1.32A 4or0A-4rxtA:
undetectable		 4or0A-4rxtA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 4rxt SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		5 / 11 PHE A 228
TYR A  48
GLY A 143
SER A 230
GLY A 255
 None
ARA  A 401 (-3.7A)
None
None
None
 1.00A 4xp4A-4rxtA:
undetectable		 4xp4A-4rxtA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4rxt SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		5 / 12 PHE A 228
ILE A 254
GLY A 142
THR A 137
THR A 101
 None
 1.10A 4ze2A-4rxtA:
undetectable		 4ze2A-4rxtA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4rxt SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		4 / 4 ILE A 213
GLY A 237
ILE A 168
LEU A 211
 None
 0.82A 5dzkl-4rxtA:
undetectable
5dzkz-4rxtA:
undetectable		 5dzkl-4rxtA:
23.08
5dzkz-4rxtA:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4rxt SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		4 / 7 GLY A 173
GLU A 102
LYS A 104
ALA A 105
 None
 0.95A 5mvsA-4rxtA:
undetectable		 5mvsA-4rxtA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 4rxt SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		5 / 12 SER A  46
VAL A 275
GLY A 237
ALA A 207
ASN A 139
 None
 1.11A 6bqgA-4rxtA:
undetectable		 6bqgA-4rxtA:
15.44