SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rxu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 4rxu PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Chloroflexus
aurantiacus) 		4 / 8 ASP A 298
ASP A 273
TYR A 377
THR A 315
 BGC  A 402 (-2.7A)
None
None
None
 1.47A 1ceaA-4rxuA:
undetectable
1ceaB-4rxuA:
undetectable		 1ceaA-4rxuA:
12.26
1ceaB-4rxuA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		 4rxu PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Chloroflexus
aurantiacus) 		5 / 11 LEU A 220
LEU A 226
ILE A 234
PHE A 193
LEU A 179
 None
 1.26A 2qeiA-4rxuA:
undetectable		 2qeiA-4rxuA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 4rxu PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Chloroflexus
aurantiacus) 		5 / 11 ALA A 146
THR A 144
ILE A 141
ALA A 126
ALA A 123
 None
 1.12A 2qhfA-4rxuA:
undetectable		 2qhfA-4rxuA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4rxu PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Chloroflexus
aurantiacus) 		5 / 11 ILE A 135
TYR A 137
GLY A  54
PHE A  72
ILE A  55
 None
 1.21A 2y7kA-4rxuA:
3.7		 2y7kA-4rxuA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4rxu PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Chloroflexus
aurantiacus) 		5 / 12 ILE A 135
TYR A 137
GLY A  54
PHE A  72
ILE A  55
 None
 1.21A 2y7kC-4rxuA:
2.8		 2y7kC-4rxuA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4rxu PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Chloroflexus
aurantiacus) 		5 / 10 ILE A 135
TYR A 137
GLY A  54
PHE A  72
ILE A  55
 None
 1.24A 2y7pA-4rxuA:
3.8		 2y7pA-4rxuA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_A_SALA1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4rxu PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Chloroflexus
aurantiacus) 		5 / 9 ILE A 135
TYR A 137
GLY A  54
PHE A  72
ILE A  55
 None
 1.22A 2y7wA-4rxuA:
2.5		 2y7wA-4rxuA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 4rxu PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Chloroflexus
aurantiacus) 		3 / 3 ARG A 142
ASP A 145
ASN A 347
 None
 0.75A 2zzmA-4rxuA:
undetectable		 2zzmA-4rxuA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		 4rxu PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Chloroflexus
aurantiacus) 		4 / 7 GLY A 117
ASP A 138
TRP A  65
ARG A  64
 None
BGC  A 402 (-3.0A)
BGC  A 402 (-4.3A)
BGC  A 402 (-3.9A)
 1.28A 3arrA-4rxuA:
undetectable		 3arrA-4rxuA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4rxu PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Chloroflexus
aurantiacus) 		5 / 9 LEU A 250
THR A 240
GLY A 274
ALA A 276
ILE A 268
 None
 1.32A 3jusB-4rxuA:
undetectable		 3jusB-4rxuA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)		 4rxu PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Chloroflexus
aurantiacus) 		5 / 12 ASP A 138
ILE A 111
ASP A 298
ARG A  64
ASP A  68
 BGC  A 402 (-3.0A)
None
BGC  A 402 (-2.7A)
BGC  A 402 (-3.9A)
None
 1.48A 3phaB-4rxuA:
undetectable		 3phaB-4rxuA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_C_ACRC701_1
(ALPHA-GLUCOSIDASE)		 4rxu PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Chloroflexus
aurantiacus) 		5 / 12 ASP A 138
ILE A 111
ASP A 298
ARG A  64
ASP A  68
 BGC  A 402 (-3.0A)
None
BGC  A 402 (-2.7A)
BGC  A 402 (-3.9A)
None
 1.43A 3phaC-4rxuA:
2.1		 3phaC-4rxuA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_D_ACRD701_1
(ALPHA-GLUCOSIDASE)		 4rxu PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Chloroflexus
aurantiacus) 		5 / 12 ASP A 138
ILE A 111
ASP A 298
ARG A  64
ASP A  68
 BGC  A 402 (-3.0A)
None
BGC  A 402 (-2.7A)
BGC  A 402 (-3.9A)
None
 1.44A 3phaD-4rxuA:
undetectable		 3phaD-4rxuA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 4rxu PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Chloroflexus
aurantiacus) 		5 / 12 ASP A 138
PHE A  72
ASP A 298
ARG A  64
ASP A  68
 BGC  A 402 (-3.0A)
None
BGC  A 402 (-2.7A)
BGC  A 402 (-3.9A)
None
 1.45A 3welA-4rxuA:
2.1		 3welA-4rxuA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEM_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 4rxu PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Chloroflexus
aurantiacus) 		5 / 12 ASP A 138
PHE A  72
ASP A 298
ARG A  64
ASP A  68
 BGC  A 402 (-3.0A)
None
BGC  A 402 (-2.7A)
BGC  A 402 (-3.9A)
None
 1.45A 3wemA-4rxuA:
undetectable		 3wemA-4rxuA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 4rxu PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Chloroflexus
aurantiacus) 		5 / 12 ASP A 138
PHE A  72
ASP A 298
ARG A  64
ASP A  68
 BGC  A 402 (-3.0A)
None
BGC  A 402 (-2.7A)
BGC  A 402 (-3.9A)
None
 1.46A 3weoA-4rxuA:
undetectable		 3weoA-4rxuA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4rxu PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Chloroflexus
aurantiacus) 		3 / 3 LYS A 318
ASN A 367
ASP A 298
 BGC  A 402 (-2.9A)
None
BGC  A 402 (-2.7A)
 0.90A 4o1eA-4rxuA:
undetectable		 4o1eA-4rxuA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 4rxu PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Chloroflexus
aurantiacus) 		4 / 4 SER A 155
ASP A 186
ASP A 243
ASP A 298
 None
BGC  A 402 (-2.7A)
None
BGC  A 402 (-2.7A)
 1.48A 4uciA-4rxuA:
1.5		 4uciA-4rxuA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 4rxu PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Chloroflexus
aurantiacus) 		4 / 4 SER A 155
ASP A 186
ASP A 243
ASP A 298
 None
BGC  A 402 (-2.7A)
None
BGC  A 402 (-2.7A)
 1.49A 4uciB-4rxuA:
undetectable		 4uciB-4rxuA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 4rxu PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Chloroflexus
aurantiacus) 		4 / 6 PHE A 153
ARG A  64
ASP A 273
GLY A 296
 None
BGC  A 402 (-3.9A)
None
None
 1.25A 5mraA-4rxuA:
undetectable
5mraB-4rxuA:
undetectable		 5mraA-4rxuA:
18.95
5mraB-4rxuA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MD4_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4rxu PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Chloroflexus
aurantiacus) 		5 / 12 GLY A 296
GLN A 297
TYR A 377
LEU A 372
ILE A 307
 None
BGC  A 402 ( 4.3A)
None
None
None
 1.39A 6md4A-4rxuA:
undetectable		 6md4A-4rxuA:
13.47