SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rxv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GSF_C_EAAC223_1 (GLUTATHIONE TRANSFERASE A1-1)	4rxv	HYPOTHETICAL PROTEIN LPG0944 (Legionella pneumophila)	4 / 8	TYR A 17 LEU A 112 VAL A 126 PHE A 104	None	1.02A	1gsfC-4rxvA: undetectable	1gsfC-4rxvA: 18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RET_A_DGXA1107_1 (SODIUM/POTASSIUM-TRA NSPORTING ATPASE SUBUNIT ALPHA-1)	4rxv	HYPOTHETICAL PROTEIN LPG0944 (Legionella pneumophila)	5 / 12	ASP A 24 PHE A 20 GLY A 175 ALA A 173 PHE A 104	None	1.06A	4retA-4rxvA: undetectable	4retA-4rxvA: 11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VVN_B_H4BB502_1 (NITRIC OXIDE SYNTHASE, ENDOTHELIAL)	4rxv	HYPOTHETICAL PROTEIN LPG0944 (Legionella pneumophila)	4 / 7	TRP A 62 PHE A 59 SER A 99 VAL A 21	None	1.34A	5vvnA-4rxvA: undetectable 5vvnB-4rxvA: undetectable	5vvnA-4rxvA: 19.73 5vvnB-4rxvA: 19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FGD_A_ACTA812_0 (GEPHYRIN)	4rxv	HYPOTHETICAL PROTEIN LPG0944 (Legionella pneumophila)	4 / 6	ARG A 97 LYS A 19 PHE A 20 VAL A 174	None	0.91A	6fgdA-4rxvA: undetectable	6fgdA-4rxvA: 21.62

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1GSF_C_EAAC223_1","GLUTATHIONE TRANSFERASE A1-1","4rxv","HYPOTHETICAL PROTEIN LPG0944","Legionella pneumophila",4,"TYR A  17;LEU A 112;VAL A 126;PHE A 104","None","1.02A","1gsfC-4rxvA:undetectable","1gsfC-4rxvA:18.91"],["4RET_A_DGXA1107_1","SODIUM\/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA-1","4rxv","HYPOTHETICAL PROTEIN LPG0944","Legionella pneumophila",5,"ASP A  24;PHE A  20;GLY A 175;ALA A 173;PHE A 104","None","1.06A","4retA-4rxvA:undetectable","4retA-4rxvA:11.61"],["5VVN_B_H4BB502_1","NITRIC OXIDE SYNTHASE, ENDOTHELIAL;NITRIC OXIDE SYNTHASE, ENDOTHELIAL","4rxv","HYPOTHETICAL PROTEIN LPG0944","Legionella pneumophila",4,"TRP A  62;PHE A  59;SER A  99;VAL A  21","None","1.34A","5vvnA-4rxvA:undetectable;5vvnB-4rxvA:undetectable","5vvnA-4rxvA:19.73;5vvnB-4rxvA:19.73"],["6FGD_A_ACTA812_0","GEPHYRIN","4rxv","HYPOTHETICAL PROTEIN LPG0944","Legionella pneumophila",4,"ARG A  97;LYS A  19;PHE A  20;VAL A 174","None","0.91A","6fgdA-4rxvA:undetectable","6fgdA-4rxvA:21.62"]]