SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rxx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 4rxx UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 38
(Homo
sapiens) 		4 / 7 VAL A  60
ASP A  54
LEU A  48
ILE A  21
 None
 1.05A 3avpA-4rxxA:
undetectable		 3avpA-4rxxA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4rxx UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 38
(Homo
sapiens) 		5 / 12 SER A 279
VAL A 326
GLY A 329
ALA A 330
LEU A 334
 None
 0.81A 3hs6A-4rxxA:
1.6		 3hs6A-4rxxA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB323_0
(INVASIN IPAD)		 4rxx UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 38
(Homo
sapiens) 		4 / 7 ILE A 103
ILE A 107
VAL A  85
LEU A  88
 None
 0.64A 3r9vA-4rxxA:
undetectable
3r9vB-4rxxA:
undetectable		 3r9vA-4rxxA:
19.30
3r9vB-4rxxA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 4rxx UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 38
(Homo
sapiens) 		5 / 9 LEU A 252
LEU A 214
ILE A 175
PHE A 221
VAL A 220
 None
 1.45A 3tmzA-4rxxA:
undetectable		 3tmzA-4rxxA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 4rxx UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 38
(Homo
sapiens) 		3 / 3 ARG A 320
PHE A 323
PRO A 324
 None
 0.81A 3zoaB-4rxxA:
undetectable		 3zoaB-4rxxA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4rxx UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 38
(Homo
sapiens) 		4 / 7 VAL A 352
ILE A 351
HIS A 343
LEU A 311
 None
 0.86A 4l1wA-4rxxA:
undetectable		 4l1wA-4rxxA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)		 4rxx UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 38
(Homo
sapiens) 		3 / 3 PHE A 178
THR A 152
LEU A 171
 None
 0.73A 4qztA-4rxxA:
undetectable		 4qztA-4rxxA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_A_QI9A602_0
(CYTOCHROME P450 2D6)		 4rxx UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 38
(Homo
sapiens) 		5 / 9 PHE A  80
LEU A 111
THR A  46
VAL A  85
LEU A  50
 None
 1.49A 4wnvA-4rxxA:
undetectable		 4wnvA-4rxxA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 4rxx UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 38
(Homo
sapiens) 		4 / 7 ARG A 320
VAL A 317
LEU A 278
SER A 279
 None
 1.06A 4zphA-4rxxA:
undetectable
4zphB-4rxxA:
undetectable		 4zphA-4rxxA:
22.05
4zphB-4rxxA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		 4rxx UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 38
(Homo
sapiens) 		5 / 12 MET A 385
ILE A 381
LEU A 377
LEU A 334
LEU A 321
 None
 1.16A 5tiwA-4rxxA:
undetectable		 5tiwA-4rxxA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 4rxx UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 38
(Homo
sapiens) 		3 / 3 ASP A 259
SER A 225
SER A 266
 None
 0.80A 6mxtA-4rxxA:
undetectable		 6mxtA-4rxxA:
22.81