SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ry0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_B_KANB501_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 4ry0 PROBABLE RIBOSE ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 9 ASP A  67
ASP A 162
SER A 193
ASP A 243
THR A 220
 None
RIP  A 401 (-3.0A)
None
RIP  A 401 (-2.6A)
RIP  A 401 ( 4.8A)
 1.17A 1m4iB-4ry0A:
0.0		 1m4iB-4ry0A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4ry0 PROBABLE RIBOSE ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 10 ASP A 115
ASN A 132
ILE A 167
GLY A 166
GLY A  93
 RIP  A 401 (-2.8A)
None
None
None
CL  A 402 (-3.5A)
 1.00A 1mehA-4ry0A:
undetectable		 1mehA-4ry0A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_C_SAMC303_0
(HEMK PROTEIN)		 4ry0 PROBABLE RIBOSE ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 12 GLY A 217
ALA A 165
VAL A 240
GLU A 142
ASN A 132
 None
 1.17A 1sg9C-4ry0A:
5.0		 1sg9C-4ry0A:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 4ry0 PROBABLE RIBOSE ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		6 / 12 GLY A  48
ILE A 128
MET A 293
LEU A 271
VAL A 273
ALA A 272
 None
 1.14A 1v2xA-4ry0A:
4.4		 1v2xA-4ry0A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 4ry0 PROBABLE RIBOSE ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		3 / 3 SER A 169
TYR A 172
HIS A 173
 None
 0.60A 2r2vD-4ry0A:
undetectable		 2r2vD-4ry0A:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_A_T44A128_1
(TRANSTHYRETIN)		 4ry0 PROBABLE RIBOSE ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		4 / 4 LYS A 305
LEU A 311
ALA A 303
LEU A 262
 None
 1.50A 2roxA-4ry0A:
undetectable		 2roxA-4ry0A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		 4ry0 PROBABLE RIBOSE ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 12 ASP A 219
GLY A 244
LEU A 306
SER A 251
ALA A 303
 None
 1.04A 3d91A-4ry0A:
undetectable		 3d91A-4ry0A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4ry0 PROBABLE RIBOSE ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 12 GLU A 160
GLY A  93
ASP A  68
ALA A  69
ASP A  95
 None
CL  A 402 (-3.5A)
None
None
None
 0.87A 3nvkF-4ry0A:
undetectable
3nvkJ-4ry0A:
4.0		 3nvkF-4ry0A:
21.11
3nvkJ-4ry0A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4ry0 PROBABLE RIBOSE ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 12 LEU A 306
ALA A 265
GLY A 244
SER A 245
ALA A 269
 None
 1.22A 3ou6C-4ry0A:
2.2		 3ou6C-4ry0A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 4ry0 PROBABLE RIBOSE ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		4 / 8 ASN A  39
ASP A 115
SER A 130
ASP A  90
 RIP  A 401 (-3.2A)
RIP  A 401 (-2.8A)
None
None
 1.07A 3sg9B-4ry0A:
undetectable		 3sg9B-4ry0A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ry0 PROBABLE RIBOSE ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		4 / 8 ASP A 243
ASP A  67
ASN A 132
ASP A 115
 RIP  A 401 (-2.6A)
None
None
RIP  A 401 (-2.8A)
 1.11A 4feuD-4ry0A:
undetectable		 4feuD-4ry0A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 4ry0 PROBABLE RIBOSE ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		4 / 7 LEU A 297
VAL A 296
GLU A 142
TYR A 172
 None
 1.06A 4lb2A-4ry0A:
undetectable		 4lb2A-4ry0A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 4ry0 PROBABLE RIBOSE ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		3 / 3 PRO A 180
MET A 182
TYR A 179
 None
 1.02A 4qa2B-4ry0A:
undetectable		 4qa2B-4ry0A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y9T_A_PA1A401_1
(ABC TRANSPORTER,
SOLUTE BINDING
PROTEIN)		 4ry0 PROBABLE RIBOSE ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		6 / 12 PHE A  41
ASP A 115
ARG A 116
ASP A 162
TRP A 192
GLN A 263
 RIP  A 401 ( 4.0A)
RIP  A 401 (-2.8A)
RIP  A 401 (-3.9A)
RIP  A 401 (-3.0A)
RIP  A 401 (-3.5A)
RIP  A 401 (-3.2A)
 0.64A 4y9tA-4ry0A:
35.4		 4y9tA-4ry0A:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BR1_A_X6XA401_1
(ABC TRANSPORTER,
BINDING PROTEIN)		 4ry0 PROBABLE RIBOSE ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		6 / 11 PHE A  41
ASP A 115
ARG A 116
ASP A 162
TRP A 192
GLN A 263
 RIP  A 401 ( 4.0A)
RIP  A 401 (-2.8A)
RIP  A 401 (-3.9A)
RIP  A 401 (-3.0A)
RIP  A 401 (-3.5A)
RIP  A 401 (-3.2A)
 0.62A 5br1A-4ry0A:
35.3		 5br1A-4ry0A:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4ry0 PROBABLE RIBOSE ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		4 / 8 GLN A 263
VAL A 157
ARG A 168
ASP A 115
 RIP  A 401 (-3.2A)
None
RIP  A 401 (-2.9A)
RIP  A 401 (-2.8A)
 1.07A 6hu9a-4ry0A:
undetectable
6hu9e-4ry0A:
undetectable		 6hu9a-4ry0A:
19.04
6hu9e-4ry0A:
19.44