SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ry8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E3V_A_DXCA801_0
(STEROID
DELTA-ISOMERASE)		 4ry8 PERIPLASMIC BINDING
PROTEIN
(Pseudothermotoga
lettingae) 		5 / 12 ASP A 137
GLY A 271
PHE A 121
VAL A 277
ASP A 122
 SR1  A 401 ( 4.9A)
None
None
None
SR1  A 401 (-3.1A)
 1.04A 1e3vA-4ry8A:
undetectable		 1e3vA-4ry8A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4ry8 PERIPLASMIC BINDING
PROTEIN
(Pseudothermotoga
lettingae) 		5 / 12 ALA A 210
ILE A 159
VAL A 161
ALA A 222
PHE A 227
 None
 1.00A 1uduB-4ry8A:
undetectable		 1uduB-4ry8A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 4ry8 PERIPLASMIC BINDING
PROTEIN
(Pseudothermotoga
lettingae) 		4 / 6 LEU A 294
ILE A 133
VAL A 119
ALA A 284
 None
 1.02A 2j5mA-4ry8A:
undetectable		 2j5mA-4ry8A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 4ry8 PERIPLASMIC BINDING
PROTEIN
(Pseudothermotoga
lettingae) 		5 / 12 ALA A 281
ALA A  60
VAL A  65
VAL A 130
ILE A  96
 None
 1.09A 3czhA-4ry8A:
undetectable		 3czhA-4ry8A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 4ry8 PERIPLASMIC BINDING
PROTEIN
(Pseudothermotoga
lettingae) 		5 / 12 ALA A 281
ALA A  60
VAL A  65
VAL A 130
ILE A  96
 None
 1.07A 3czhB-4ry8A:
undetectable		 3czhB-4ry8A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4ry8 PERIPLASMIC BINDING
PROTEIN
(Pseudothermotoga
lettingae) 		3 / 3 ASN A 162
ASP A 170
ARG A  41
 None
 0.87A 3k13C-4ry8A:
undetectable		 3k13C-4ry8A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 4ry8 PERIPLASMIC BINDING
PROTEIN
(Pseudothermotoga
lettingae) 		4 / 6 PHE A  48
TYR A  52
VAL A 300
PHE A 121
 SR1  A 401 (-3.6A)
None
None
None
 1.03A 3ltwA-4ry8A:
undetectable		 3ltwA-4ry8A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_2
(GLUCOCORTICOID
RECEPTOR)		 4ry8 PERIPLASMIC BINDING
PROTEIN
(Pseudothermotoga
lettingae) 		4 / 6 LEU A 143
MET A 175
GLN A 147
TYR A 247
 None
 1.47A 3mnoA-4ry8A:
undetectable		 3mnoA-4ry8A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_2
(GLUCOCORTICOID
RECEPTOR)		 4ry8 PERIPLASMIC BINDING
PROTEIN
(Pseudothermotoga
lettingae) 		4 / 6 LEU A 143
MET A 175
GLN A 147
TYR A 247
 None
 1.46A 3mnpA-4ry8A:
undetectable		 3mnpA-4ry8A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_2
(POL POLYPROTEIN)		 4ry8 PERIPLASMIC BINDING
PROTEIN
(Pseudothermotoga
lettingae) 		5 / 9 GLY A 230
ALA A 231
GLY A 193
LEU A 221
VAL A 220
 None
 1.03A 3u7sB-4ry8A:
undetectable		 3u7sB-4ry8A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)		 4ry8 PERIPLASMIC BINDING
PROTEIN
(Pseudothermotoga
lettingae) 		5 / 12 GLY A 230
ALA A 231
ILE A 159
GLY A 193
VAL A 220
 None
 1.00A 3ucbA-4ry8A:
undetectable		 3ucbA-4ry8A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_2
(PROTEASE)		 4ry8 PERIPLASMIC BINDING
PROTEIN
(Pseudothermotoga
lettingae) 		5 / 12 GLY A 230
ALA A 231
ILE A 159
GLY A 193
VAL A 220
 None
 1.02A 3ucbB-4ry8A:
undetectable		 3ucbB-4ry8A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_1
(MEMBRANE LIPOPROTEIN
TPN38(B))		 4ry8 PERIPLASMIC BINDING
PROTEIN
(Pseudothermotoga
lettingae) 		5 / 12 SER A  47
ALA A  56
GLN A 135
GLY A  46
ASP A 250
 None
None
SR1  A 401 (-3.5A)
None
SR1  A 401 (-2.7A)
 1.41A 4iilA-4ry8A:
19.4		 4iilA-4ry8A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4ry8 PERIPLASMIC BINDING
PROTEIN
(Pseudothermotoga
lettingae) 		4 / 8 ALA A  56
ALA A  60
ALA A 285
ALA A 281
 None
 0.77A 4twdF-4ry8A:
undetectable
4twdG-4ry8A:
undetectable
4twdH-4ry8A:
undetectable
4twdI-4ry8A:
undetectable
4twdJ-4ry8A:
undetectable		 4twdF-4ry8A:
21.65
4twdG-4ry8A:
21.65
4twdH-4ry8A:
21.65
4twdI-4ry8A:
21.65
4twdJ-4ry8A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4ry8 PERIPLASMIC BINDING
PROTEIN
(Pseudothermotoga
lettingae) 		4 / 8 ALA A 285
ALA A 281
ALA A  56
ALA A  60
 None
 0.76A 4twdF-4ry8A:
undetectable
4twdG-4ry8A:
undetectable
4twdH-4ry8A:
undetectable
4twdI-4ry8A:
undetectable
4twdJ-4ry8A:
undetectable		 4twdF-4ry8A:
21.65
4twdG-4ry8A:
21.65
4twdH-4ry8A:
21.65
4twdI-4ry8A:
21.65
4twdJ-4ry8A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 4ry8 PERIPLASMIC BINDING
PROTEIN
(Pseudothermotoga
lettingae) 		4 / 5 ALA A  93
ALA A 285
ILE A  37
LEU A  67
 None
 0.81A 5jncD-4ry8A:
undetectable		 5jncD-4ry8A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4ry8 PERIPLASMIC BINDING
PROTEIN
(Pseudothermotoga
lettingae) 		4 / 7 ALA A 324
ASP A 255
ILE A 256
ILE A 260
 None
 0.97A 6fbnA-4ry8A:
undetectable		 6fbnA-4ry8A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_N_PCFN606_0
(CYTOCHROME B)		 4ry8 PERIPLASMIC BINDING
PROTEIN
(Pseudothermotoga
lettingae) 		5 / 12 MET A 223
ALA A 222
THR A 205
VAL A 246
VAL A 267
 None
 1.37A 6hu9N-4ry8A:
undetectable		 6hu9N-4ry8A:
20.20