SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ry9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4ry9 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Verminephrobacte
r
eiseniae) 		5 / 12 GLY A  39
LEU A  95
GLY A  91
SER A 113
VAL A 109
 None
None
GOL  A 403 (-3.3A)
None
None
 1.23A 1fduC-4ry9A:
6.5		 1fduC-4ry9A:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4ry9 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Verminephrobacte
r
eiseniae) 		4 / 6 ASN A 171
ASN A 280
SER A 138
ASN A 140
 TLZ  A 401 (-3.0A)
TLZ  A 401 (-3.7A)
None
None
 1.27A 1h7xA-4ry9A:
4.2		 1h7xA-4ry9A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_3
(HIV-1 PROTEASE)		 4ry9 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Verminephrobacte
r
eiseniae) 		5 / 12 LEU A 105
ASP A  86
GLY A  39
ILE A  96
VAL A 109
 None
 1.01A 1hxbB-4ry9A:
undetectable		 1hxbB-4ry9A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 4ry9 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Verminephrobacte
r
eiseniae) 		5 / 10 LEU A  64
ALA A  56
VAL A  40
ILE A  38
VAL A  68
 None
 0.91A 2nnjA-4ry9A:
undetectable		 2nnjA-4ry9A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_3
(PROTEASE)		 4ry9 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Verminephrobacte
r
eiseniae) 		5 / 12 LEU A 105
ASP A  86
GLY A  39
ILE A  96
VAL A 109
 None
 0.97A 2nnkB-4ry9A:
undetectable		 2nnkB-4ry9A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_1
(PROTEASE)		 4ry9 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Verminephrobacte
r
eiseniae) 		5 / 11 LEU A 105
ASP A  86
GLY A  39
ILE A  96
VAL A 109
 None
 1.05A 2o4pA-4ry9A:
undetectable		 2o4pA-4ry9A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)		 4ry9 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Verminephrobacte
r
eiseniae) 		4 / 8 LYS A 270
TYR A 324
ASN A 325
LYS A 327
 None
 1.37A 3bjwD-4ry9A:
undetectable		 3bjwD-4ry9A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4ry9 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Verminephrobacte
r
eiseniae) 		4 / 8 GLY A 232
VAL A 238
ILE A 162
VAL A 181
 None
 0.76A 3fi0B-4ry9A:
undetectable		 3fi0B-4ry9A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_G_TRPG1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4ry9 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Verminephrobacte
r
eiseniae) 		4 / 8 GLY A 232
VAL A 238
ILE A 162
VAL A 181
 None
 0.66A 3fi0G-4ry9A:
undetectable		 3fi0G-4ry9A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_Q_TRPQ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4ry9 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Verminephrobacte
r
eiseniae) 		4 / 8 GLY A 232
VAL A 238
ILE A 162
VAL A 181
 None
 0.69A 3fi0Q-4ry9A:
undetectable		 3fi0Q-4ry9A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_1
(HIV-1 PROTEASE)		 4ry9 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Verminephrobacte
r
eiseniae) 		5 / 12 LEU A 105
ASP A  86
GLY A  39
ILE A  96
VAL A 109
 None
 1.03A 3k4vC-4ry9A:
undetectable		 3k4vC-4ry9A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4ry9 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Verminephrobacte
r
eiseniae) 		5 / 12 VAL A 155
VAL A 256
LEU A 231
LEU A 254
GLY A 184
 None
 1.06A 3n8zA-4ry9A:
undetectable		 3n8zA-4ry9A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_1
(PROTEASE)		 4ry9 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Verminephrobacte
r
eiseniae) 		5 / 12 LEU A 105
ASP A  86
GLY A  39
ILE A  96
VAL A 109
 None
 1.02A 3nduC-4ry9A:
undetectable		 3nduC-4ry9A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 4ry9 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Verminephrobacte
r
eiseniae) 		3 / 3 ASP A 260
GLU A 264
SER A 124
 TLZ  A 401 ( 2.7A)
None
TLZ  A 401 (-2.8A)
 0.73A 3p2kA-4ry9A:
undetectable		 3p2kA-4ry9A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 4ry9 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Verminephrobacte
r
eiseniae) 		5 / 12 ARG A 177
GLY A 144
ASP A 260
PHE A 323
SER A 138
 TLZ  A 401 (-2.9A)
None
TLZ  A 401 ( 2.7A)
GOL  A 406 (-4.8A)
None
 1.10A 3tkaA-4ry9A:
3.9		 3tkaA-4ry9A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_2
(ASPARTYL PROTEASE)		 4ry9 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Verminephrobacte
r
eiseniae) 		5 / 10 LEU A 105
ASP A  86
GLY A  39
ILE A  96
VAL A 109
 None
 0.98A 4dqbB-4ry9A:
undetectable		 4dqbB-4ry9A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_2
(ASPARTYL PROTEASE)		 4ry9 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Verminephrobacte
r
eiseniae) 		5 / 10 LEU A 105
ASP A  86
GLY A  39
ILE A  96
VAL A 109
 None
 0.97A 4dqeB-4ry9A:
undetectable		 4dqeB-4ry9A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_2
(WILD-TYPE HIV-1
PROTEASE DIMER)		 4ry9 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Verminephrobacte
r
eiseniae) 		5 / 10 LEU A 105
ASP A  86
GLY A  39
ILE A  96
VAL A 109
 None
 0.99A 4dqhB-4ry9A:
undetectable		 4dqhB-4ry9A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4ry9 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Verminephrobacte
r
eiseniae) 		5 / 10 ALA A 163
ILE A 253
ALA A 244
ALA A 241
ILE A 245
 None
 1.07A 4lbgA-4ry9A:
4.5		 4lbgA-4ry9A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4ry9 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Verminephrobacte
r
eiseniae) 		5 / 9 ALA A 163
ILE A 253
ALA A 244
ALA A 241
ILE A 245
 None
 1.01A 4lbgB-4ry9A:
6.0		 4lbgB-4ry9A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4ry9 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Verminephrobacte
r
eiseniae) 		4 / 7 ASP A 291
ARG A  60
GLY A  61
GLU A  63
 None
 1.12A 5btfA-4ry9A:
undetectable
5btfC-4ry9A:
undetectable
5btfD-4ry9A:
2.6		 5btfA-4ry9A:
21.59
5btfC-4ry9A:
21.59
5btfD-4ry9A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 4ry9 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Verminephrobacte
r
eiseniae) 		5 / 12 LEU A 220
TYR A 274
VAL A 181
GLY A 204
LEU A 214
 None
 1.19A 5hg0A-4ry9A:
2.8		 5hg0A-4ry9A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 4ry9 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Verminephrobacte
r
eiseniae) 		5 / 12 LEU A  94
ALA A  52
VAL A  40
GLY A  39
ILE A  38
 None
 0.74A 5j2tC-4ry9A:
4.0		 5j2tC-4ry9A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_2
(PROTEASE PR5-SQV)		 4ry9 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Verminephrobacte
r
eiseniae) 		5 / 11 LEU A 105
ASP A  86
GLY A  39
ILE A  96
VAL A 109
 None
 1.04A 5kr2B-4ry9A:
undetectable		 5kr2B-4ry9A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4ry9 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Verminephrobacte
r
eiseniae) 		5 / 12 ILE A  96
VAL A  84
VAL A  88
ALA A  57
VAL A  68
 None
None
GOL  A 403 ( 4.1A)
None
None
 1.21A 5n0rA-4ry9A:
3.2		 5n0rA-4ry9A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4ry9 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Verminephrobacte
r
eiseniae) 		5 / 12 ILE A  96
VAL A  84
VAL A  88
ALA A  57
VAL A  68
 None
None
GOL  A 403 ( 4.1A)
None
None
 1.22A 5n0wA-4ry9A:
3.9		 5n0wA-4ry9A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUJ_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 4ry9 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Verminephrobacte
r
eiseniae) 		4 / 8 ALA A  51
ILE A 122
ASN A  98
VAL A  40
 None
None
TLZ  A 401 ( 4.4A)
None
 0.81A 5nujA-4ry9A:
undetectable		 5nujA-4ry9A:
16.78