SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rya'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 4rya ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL)
(Agrobacterium
vitis) 		4 / 5 TYR A 135
PRO A 133
LEU A 123
ARG A  65
 MTL  A 501 (-4.5A)
None
None
MTL  A 501 (-3.1A)
 1.36A 1i2wA-4ryaA:
undetectable		 1i2wA-4ryaA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 4rya ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL)
(Agrobacterium
vitis) 		4 / 7 ASP A  34
GLU A  61
GLU A 247
GLU A 191
 None
MTL  A 501 (-2.8A)
None
None
 1.11A 1knyA-4ryaA:
undetectable
1knyB-4ryaA:
undetectable		 1knyA-4ryaA:
20.60
1knyB-4ryaA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4rya ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL)
(Agrobacterium
vitis) 		4 / 5 GLY A  93
GLN A  95
TRP A  97
VAL A  72
 None
 1.38A 1rs6B-4ryaA:
undetectable		 1rs6B-4ryaA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4rya ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL)
(Agrobacterium
vitis) 		4 / 6 GLY A  93
ILE A  91
GLN A  95
VAL A  72
 None
 0.81A 1rs7B-4ryaA:
undetectable		 1rs7B-4ryaA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_0
(AMINOMETHYLTRANSFERA
SE)		 4rya ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL)
(Agrobacterium
vitis) 		5 / 12 VAL A 341
VAL A 332
TYR A 350
TYR A 355
TYR A 135
 None
None
None
None
MTL  A 501 (-4.5A)
 1.41A 1wopA-4ryaA:
0.0		 1wopA-4ryaA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 4rya ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL)
(Agrobacterium
vitis) 		5 / 11 GLY A 397
ILE A 193
ASN A 192
ALA A 187
GLU A 430
 None
 1.27A 2vdvF-4ryaA:
undetectable		 2vdvF-4ryaA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA602_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 4rya ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL)
(Agrobacterium
vitis) 		5 / 7 ASN A 192
SER A 241
ALA A 408
ALA A 409
ALA A 411
 None
 1.11A 3a2qA-4ryaA:
undetectable		 3a2qA-4ryaA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 4rya ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL)
(Agrobacterium
vitis) 		4 / 8 VAL A 265
LEU A 349
GLY A 344
TYR A 350
 None
 0.79A 3af0A-4ryaA:
undetectable		 3af0A-4ryaA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 4rya ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL)
(Agrobacterium
vitis) 		5 / 12 GLY A  85
GLU A  88
ARG A  65
ALA A 391
GLU A 137
 None
None
MTL  A 501 (-3.1A)
None
MTL  A 501 (-3.0A)
 1.15A 3ckkA-4ryaA:
undetectable		 3ckkA-4ryaA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4rya ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL)
(Agrobacterium
vitis) 		5 / 12 LEU A 101
GLU A  88
ALA A  89
MET A  82
LEU A 123
 None
 1.45A 3ou6D-4ryaA:
undetectable		 3ou6D-4ryaA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 4rya ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL)
(Agrobacterium
vitis) 		4 / 4 ASN A 192
ALA A 187
GLY A 403
THR A 400
 None
 1.05A 4bboC-4ryaA:
undetectable		 4bboC-4ryaA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4rya ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL)
(Agrobacterium
vitis) 		5 / 6 GLY A  93
ILE A  91
GLN A  95
TRP A  97
VAL A  72
 None
 1.34A 4d39B-4ryaA:
undetectable		 4d39B-4ryaA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4rya ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL)
(Agrobacterium
vitis) 		4 / 6 GLY A  93
ILE A  91
GLN A  95
VAL A  72
 None
 0.87A 4kcnA-4ryaA:
undetectable		 4kcnA-4ryaA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 4rya ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL)
(Agrobacterium
vitis) 		3 / 3 ASP A  34
TRP A 260
SER A 268
 None
 0.85A 4lrhB-4ryaA:
undetectable		 4lrhB-4ryaA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 4rya ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL)
(Agrobacterium
vitis) 		3 / 3 ASP A  34
TRP A 260
SER A 268
 None
 0.84A 4lrhF-4ryaA:
undetectable		 4lrhF-4ryaA:
17.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RYA_A_ACTA502_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 4rya ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL)
(Agrobacterium
vitis) 		4 / 4 LYS A 294
ARG A 295
GLY A 296
ASP A 373
 ACT  A 502 (-4.6A)
None
ACT  A 502 (-3.7A)
None
 0.00A 4ryaA-4ryaA:
74.9		 4ryaA-4ryaA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RYA_A_MTLA501_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 4rya ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL)
(Agrobacterium
vitis) 		12 / 12 ASN A  32
ARG A  65
ARG A 184
GLY A 190
ALA A 194
PHE A 245
ALA A 263
VAL A 265
TRP A 298
TRP A 300
TRP A 302
GLN A 388
 MTL  A 501 (-3.5A)
MTL  A 501 (-3.1A)
MTL  A 501 (-2.7A)
MTL  A 501 (-3.6A)
MTL  A 501 ( 3.7A)
MTL  A 501 ( 3.6A)
MTL  A 501 ( 3.8A)
None
MTL  A 501 ( 4.3A)
MTL  A 501 (-3.6A)
MTL  A 501 (-4.0A)
MTL  A 501 (-3.8A)
 0.03A 4ryaA-4ryaA:
74.9		 4ryaA-4ryaA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 4rya ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL)
(Agrobacterium
vitis) 		3 / 3 GLU A  61
TYR A 135
GLU A 137
 MTL  A 501 (-2.8A)
MTL  A 501 (-4.5A)
MTL  A 501 (-3.0A)
 0.02A 4ryaA-4ryaA:
74.9		 4ryaA-4ryaA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4rya ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL)
(Agrobacterium
vitis) 		5 / 12 ILE A 369
ASP A 262
ALA A 198
VAL A 387
GLY A 190
 None
None
None
None
MTL  A 501 (-3.6A)
 1.20A 5igiA-4ryaA:
undetectable		 5igiA-4ryaA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 4rya ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL)
(Agrobacterium
vitis) 		5 / 12 ILE A  84
GLY A  85
SER A 301
LEU A 101
LEU A 104
 None
 1.19A 5nfjB-4ryaA:
undetectable		 5nfjB-4ryaA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 4rya ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL)
(Agrobacterium
vitis) 		5 / 12 ILE A  84
GLY A  85
SER A 301
LEU A 101
LEU A 104
 None
 1.18A 5nfjC-4ryaA:
undetectable		 5nfjC-4ryaA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 4rya ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL)
(Agrobacterium
vitis) 		3 / 3 LEU A  59
VAL A  68
ASP A  71
 None
 0.55A 5x23A-4ryaA:
undetectable		 5x23A-4ryaA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9A_A_AR3A201_1
(PEPTIDYL-TRNA
HYDROLASE)		 4rya ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL)
(Agrobacterium
vitis) 		4 / 6 ALA A 419
LYS A 222
GLN A 226
ASP A 230
 None
 1.42A 5y9aA-4ryaA:
undetectable		 5y9aA-4ryaA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 4rya ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL)
(Agrobacterium
vitis) 		5 / 10 GLY A 399
GLY A 397
ILE A 193
ALA A 401
GLY A 188
 None
 1.10A 6e5zA-4ryaA:
undetectable		 6e5zA-4ryaA:
20.71