SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ryb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C8L_A_CFFA940_1
(PROTEIN (GLYCOGEN
PHOSPHORYLASE))		 4ryb 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Neisseria
meningitidis) 		4 / 6 ASN A 125
ALA A   4
GLY A 175
TYR A   3
 None
 1.10A 1c8lA-4rybA:
undetectable		 1c8lA-4rybA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 4ryb 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Neisseria
meningitidis) 		5 / 12 ILE A 291
ILE A 296
TYR A 320
ARG A 292
THR A   9
 None
 1.21A 1kijB-4rybA:
undetectable		 1kijB-4rybA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 4ryb 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Neisseria
meningitidis) 		4 / 6 ALA A 136
LEU A 137
ILE A  74
SER A 169
 None
 1.05A 1sbrA-4rybA:
undetectable
1sbrB-4rybA:
undetectable		 1sbrA-4rybA:
24.53
1sbrB-4rybA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)		 4ryb 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Neisseria
meningitidis) 		5 / 12 LEU A  55
ALA A  46
ILE A  45
HIS A 247
LEU A 285
 None
 1.08A 1tw4A-4rybA:
0.6		 1tw4A-4rybA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4ryb 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Neisseria
meningitidis) 		5 / 12 LEU A 285
LEU A  13
GLU A  50
ASP A 109
ALA A  56
 None
 1.06A 2bm9A-4rybA:
undetectable		 2bm9A-4rybA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4ryb 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Neisseria
meningitidis) 		4 / 8 ILE A   6
GLY A   8
LEU A 137
PHE A 117
 None
 0.82A 2vctA-4rybA:
undetectable		 2vctA-4rybA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4ryb 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Neisseria
meningitidis) 		4 / 8 ILE A   6
GLY A   8
LEU A 137
PHE A 117
 None
 0.85A 2vctB-4rybA:
undetectable		 2vctB-4rybA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4ryb 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Neisseria
meningitidis) 		4 / 7 ILE A   6
GLY A   8
LEU A 137
PHE A 117
 None
 0.82A 2vctD-4rybA:
undetectable		 2vctD-4rybA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YZQ_A_SAMA6075_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780)		 4ryb 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Neisseria
meningitidis) 		5 / 12 ASP A 152
THR A 154
ILE A 147
ILE A 208
PRO A 206
 None
 1.28A 2yzqA-4rybA:
undetectable		 2yzqA-4rybA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		 4ryb 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Neisseria
meningitidis) 		4 / 5 ASN A 125
ALA A   4
GLY A 175
TYR A   3
 None
 1.18A 3bcrA-4rybA:
undetectable		 3bcrA-4rybA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA314_0
(UNCHARACTERIZED
PROTEIN)		 4ryb 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Neisseria
meningitidis) 		5 / 12 THR A 122
LEU A 181
VAL A 230
ILE A 244
ILE A 283
 None
 1.11A 3ijdA-4rybA:
undetectable		 3ijdA-4rybA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B2000_1
(P38A)		 4ryb 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Neisseria
meningitidis) 		5 / 10 ARG A 251
ILE A 254
ILE A 296
TYR A 320
ILE A 291
 None
 1.43A 3ohtA-4rybA:
undetectable
3ohtB-4rybA:
undetectable		 3ohtA-4rybA:
20.20
3ohtB-4rybA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 4ryb 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Neisseria
meningitidis) 		5 / 12 ALA A   4
VAL A 110
ALA A 124
THR A 123
ASN A 125
 None
 1.18A 3r9cA-4rybA:
undetectable		 3r9cA-4rybA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 4ryb 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Neisseria
meningitidis) 		5 / 12 CYH A 156
THR A  35
ILE A  34
ILE A  45
ASP A  22
 None
 1.27A 3vw1D-4rybA:
undetectable		 3vw1D-4rybA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4ryb 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Neisseria
meningitidis) 		4 / 4 PRO A 284
LEU A 287
ILE A 291
ARG A 298
 None
 1.05A 4f4dA-4rybA:
undetectable		 4f4dA-4rybA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4ryb 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Neisseria
meningitidis) 		4 / 5 PRO A 284
LEU A 287
ILE A 291
ARG A 298
 None
 0.90A 4klrA-4rybA:
undetectable		 4klrA-4rybA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)		 4ryb 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Neisseria
meningitidis) 		5 / 12 HIS A 247
ALA A 249
GLY A 309
GLY A 314
LEU A 223
 None
 1.11A 4uilH-4rybA:
undetectable
4uilL-4rybA:
undetectable		 4uilH-4rybA:
20.87
4uilL-4rybA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 4ryb 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Neisseria
meningitidis) 		5 / 12 GLY A 306
ASP A 229
VAL A 230
VAL A 245
LEU A 303
 None
 1.10A 5kocA-4rybA:
undetectable		 5kocA-4rybA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 4ryb 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Neisseria
meningitidis) 		5 / 12 ALA A 112
GLY A 140
TYR A 119
ALA A  59
ALA A 141
 None
 1.17A 5n5dA-4rybA:
undetectable		 5n5dA-4rybA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 4ryb 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Neisseria
meningitidis) 		4 / 6 HIS A 247
VAL A 113
LEU A 191
GLN A 111
 None
 1.37A 5xdhA-4rybA:
undetectable
5xdhC-4rybA:
undetectable		 5xdhA-4rybA:
14.73
5xdhC-4rybA:
14.73