SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ryf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 4ryf ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Listeria
monocytogenes) 		4 / 7 LEU H 126
ILE H 120
MET H 175
MET H 154
 None
None
None
MLI  H 301 ( 4.6A)
 0.86A 1kglA-4ryfH:
undetectable		 1kglA-4ryfH:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 4ryf ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Listeria
monocytogenes) 		5 / 9 ILE H 120
ILE H  64
GLY H  94
ALA H  96
THR H  90
 None
 1.32A 2dtjA-4ryfH:
undetectable
2dtjB-4ryfH:
undetectable		 2dtjA-4ryfH:
25.57
2dtjB-4ryfH:
25.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_B_BEZB194_0
(PUTATIVE KINASE)		 4ryf ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Listeria
monocytogenes) 		4 / 5 PRO H 161
ILE H 165
ARG H 167
ASP H 168
 None
 1.35A 2rhmB-4ryfH:
undetectable		 2rhmB-4ryfH:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_D_BEZD194_0
(PUTATIVE KINASE)		 4ryf ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Listeria
monocytogenes) 		4 / 5 PRO H 161
ILE H 165
ARG H 167
ASP H 168
 None
 1.30A 2rhmD-4ryfH:
undetectable		 2rhmD-4ryfH:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4ryf ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Listeria
monocytogenes) 		4 / 6 ILE H  77
ILE H 146
LEU H  32
MET H  99
 None
None
None
MLI  H 301 (-3.3A)
 1.09A 3adsA-4ryfH:
undetectable		 3adsA-4ryfH:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_1
(PROTEASE)		 4ryf ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Listeria
monocytogenes) 		4 / 8 ASP H  52
ALA H  86
ASP H  87
ASP H  59
 None
 0.59A 3el0A-4ryfH:
undetectable		 3el0A-4ryfH:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_1
(HIV-1 PROTEASE)		 4ryf ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Listeria
monocytogenes) 		4 / 7 ASP H  52
ALA H  86
ASP H  87
ASP H  59
 None
 0.56A 3t3cA-4ryfH:
undetectable		 3t3cA-4ryfH:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4ryf ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Listeria
monocytogenes) 		4 / 8 ALA H  96
ASP H 187
ILE H 186
ILE H 189
 None
 0.89A 4ndnB-4ryfH:
undetectable		 4ndnB-4ryfH:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4ryf ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Listeria
monocytogenes) 		4 / 8 ALA H  96
ASP H 187
ILE H 186
ILE H 189
 None
 0.93A 4ndnD-4ryfH:
undetectable		 4ndnD-4ryfH:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_1
(PROTEASE)		 4ryf ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Listeria
monocytogenes) 		5 / 11 ALA H 155
VAL H 164
GLY H 184
THR H 169
ILE H 165
 None
 0.97A 4njtA-4ryfH:
undetectable		 4njtA-4ryfH:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_1
(PROTEASE)		 4ryf ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Listeria
monocytogenes) 		5 / 11 ALA H 155
VAL H 164
GLY H 184
THR H 169
ILE H 165
 None
 0.85A 4njtC-4ryfH:
undetectable		 4njtC-4ryfH:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_2
(PROTEASE)		 4ryf ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Listeria
monocytogenes) 		5 / 10 ALA H 155
VAL H 164
GLY H 184
THR H 169
ILE H 165
 None
 1.03A 4njuB-4ryfH:
undetectable		 4njuB-4ryfH:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_2
(PROTEASE)		 4ryf ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Listeria
monocytogenes) 		5 / 10 ALA H 155
VAL H 164
GLY H 184
THR H 169
ILE H 165
 None
 1.03A 4njuD-4ryfH:
undetectable		 4njuD-4ryfH:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_1
(HIV-1 PROTEASE)		 4ryf ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Listeria
monocytogenes) 		5 / 11 ALA H 155
VAL H 164
GLY H 184
THR H 169
ILE H 165
 None
 0.97A 4rvjA-4ryfH:
undetectable		 4rvjA-4ryfH:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_1
(HIV-1 PROTEASE)		 4ryf ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Listeria
monocytogenes) 		5 / 11 ALA H 155
VAL H 164
GLY H 184
THR H 169
ILE H 165
 None
 0.97A 4rvjC-4ryfH:
undetectable		 4rvjC-4ryfH:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4ryf ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Listeria
monocytogenes) 		4 / 7 GLY H  69
SER H  98
GLY H 100
ALA H  35
 None
MLI  H 301 (-3.5A)
None
None
 0.92A 5e26A-4ryfH:
undetectable
5e26B-4ryfH:
undetectable		 5e26A-4ryfH:
19.10
5e26B-4ryfH:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4ryf ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Listeria
monocytogenes) 		4 / 6 LEU H 126
ILE H 120
MET H 175
MET H 154
 None
None
None
MLI  H 301 ( 4.6A)
 0.91A 5ljeA-4ryfH:
undetectable		 5ljeA-4ryfH:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4ryf ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Listeria
monocytogenes) 		4 / 8 ALA H  96
ASP H 187
ILE H 186
ILE H 189
 None
 0.93A 5t8sA-4ryfH:
undetectable		 5t8sA-4ryfH:
19.70