SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rz2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 4rz2 SITE-DETERMINING
PROTEIN
(Geobacillus
thermodenitrific
ans) 		5 / 9 ASP A  58
ALA A 103
SER A  74
GLY A  62
GLY A 105
 None
 1.18A 1bcuH-4rz2A:
undetectable		 1bcuH-4rz2A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 4rz2 SITE-DETERMINING
PROTEIN
(Geobacillus
thermodenitrific
ans) 		4 / 8 LEU A 223
PHE A 159
VAL A 161
VAL A  27
 None
 0.83A 1epbB-4rz2A:
undetectable		 1epbB-4rz2A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 4rz2 SITE-DETERMINING
PROTEIN
(Geobacillus
thermodenitrific
ans) 		5 / 12 PHE A 151
TYR A 150
LEU A 280
LEU A  57
THR A 106
 None
 1.28A 1mx8A-4rz2A:
undetectable		 1mx8A-4rz2A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		 4rz2 SITE-DETERMINING
PROTEIN
(Geobacillus
thermodenitrific
ans) 		5 / 12 LEU A  55
LEU A  88
LEU A 126
LEU A 123
LEU A  78
 None
 0.92A 2ouzA-4rz2A:
undetectable		 2ouzA-4rz2A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 4rz2 SITE-DETERMINING
PROTEIN
(Geobacillus
thermodenitrific
ans) 		3 / 3 LYS A 218
ILE A  25
PHE A 138
 None
 1.00A 3j7zS-4rz2A:
undetectable
3j7za-4rz2A:
undetectable		 3j7zS-4rz2A:
17.97
3j7za-4rz2A:
5.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 4rz2 SITE-DETERMINING
PROTEIN
(Geobacillus
thermodenitrific
ans) 		4 / 5 PHE A 188
ILE A 191
MET A 175
PHE A 159
 None
 1.09A 3octA-4rz2A:
undetectable		 3octA-4rz2A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)		 4rz2 SITE-DETERMINING
PROTEIN
(Geobacillus
thermodenitrific
ans) 		4 / 4 LEU A  45
SER A  40
LEU A  69
LEU A  99
 None
 1.08A 4n09A-4rz2A:
3.6		 4n09A-4rz2A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4rz2 SITE-DETERMINING
PROTEIN
(Geobacillus
thermodenitrific
ans) 		4 / 7 ASN A  38
LEU A  41
LEU A  45
LEU A  70
 None
 0.80A 4wg0L-4rz2A:
undetectable
4wg0M-4rz2A:
undetectable		 4wg0L-4rz2A:
3.95
4wg0M-4rz2A:
3.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4rz2 SITE-DETERMINING
PROTEIN
(Geobacillus
thermodenitrific
ans) 		4 / 7 PHE A 284
ILE A 119
PHE A 151
LEU A  78
 None
 0.93A 4zdzA-4rz2A:
undetectable		 4zdzA-4rz2A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4rz2 SITE-DETERMINING
PROTEIN
(Geobacillus
thermodenitrific
ans) 		4 / 7 PHE A 284
ILE A 119
PHE A 151
LEU A  78
 None
 0.84A 4ze3A-4rz2A:
undetectable		 4ze3A-4rz2A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		 4rz2 SITE-DETERMINING
PROTEIN
(Geobacillus
thermodenitrific
ans) 		4 / 6 LYS A  93
TYR A 101
TYR A 133
LEU A  55
 None
 1.38A 5bmvB-4rz2A:
5.1		 5bmvB-4rz2A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_DIFA601_1
(SERUM ALBUMIN)		 4rz2 SITE-DETERMINING
PROTEIN
(Geobacillus
thermodenitrific
ans) 		5 / 9 ASP A 219
ALA A 221
VAL A 190
GLU A 206
LYS A 209
 None
 1.45A 5dbyA-4rz2A:
undetectable		 5dbyA-4rz2A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4rz2 SITE-DETERMINING
PROTEIN
(Geobacillus
thermodenitrific
ans) 		4 / 7 GLU A 165
GLY A  32
ARG A 194
GLY A  35
 None
 0.67A 5e26A-4rz2A:
3.7
5e26B-4rz2A:
3.8		 5e26A-4rz2A:
21.43
5e26B-4rz2A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4rz2 SITE-DETERMINING
PROTEIN
(Geobacillus
thermodenitrific
ans) 		4 / 7 GLU A 165
GLY A  32
ARG A 194
GLY A  35
 None
 0.64A 5e26A-4rz2A:
3.6
5e26B-4rz2A:
3.8		 5e26A-4rz2A:
21.43
5e26B-4rz2A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_C_PAUC602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4rz2 SITE-DETERMINING
PROTEIN
(Geobacillus
thermodenitrific
ans) 		4 / 7 GLU A 165
GLY A  32
ARG A 194
GLY A  35
 None
 0.67A 5e26C-4rz2A:
3.7
5e26D-4rz2A:
3.8		 5e26C-4rz2A:
21.43
5e26D-4rz2A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4rz2 SITE-DETERMINING
PROTEIN
(Geobacillus
thermodenitrific
ans) 		4 / 8 GLU A 165
GLY A  32
ARG A 194
GLY A  35
 None
 0.68A 5e26C-4rz2A:
3.7
5e26D-4rz2A:
3.9		 5e26C-4rz2A:
21.43
5e26D-4rz2A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4rz2 SITE-DETERMINING
PROTEIN
(Geobacillus
thermodenitrific
ans) 		5 / 12 PHE A 284
ILE A 119
PHE A 151
THR A 106
LEU A  78
 None
 1.17A 5eshA-4rz2A:
undetectable		 5eshA-4rz2A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4rz2 SITE-DETERMINING
PROTEIN
(Geobacillus
thermodenitrific
ans) 		4 / 8 PHE A 284
ILE A 119
PHE A 151
LEU A  78
 None
 0.84A 5esjA-4rz2A:
undetectable		 5esjA-4rz2A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4rz2 SITE-DETERMINING
PROTEIN
(Geobacillus
thermodenitrific
ans) 		4 / 7 PHE A 284
ILE A 119
PHE A 151
LEU A  78
 None
 0.94A 5esmA-4rz2A:
undetectable		 5esmA-4rz2A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4rz2 SITE-DETERMINING
PROTEIN
(Geobacillus
thermodenitrific
ans) 		3 / 3 MET A 258
GLN A 257
ARG A 256
 None
 1.04A 5ewzB-4rz2A:
undetectable		 5ewzB-4rz2A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4rz2 SITE-DETERMINING
PROTEIN
(Geobacillus
thermodenitrific
ans) 		4 / 8 PHE A 284
ILE A 119
PHE A 151
LEU A  78
 None
 0.82A 5hs1A-4rz2A:
undetectable		 5hs1A-4rz2A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 4rz2 SITE-DETERMINING
PROTEIN
(Geobacillus
thermodenitrific
ans) 		4 / 5 GLU A 165
GLY A  32
ARG A 194
GLY A  35
 None
 0.61A 5kprA-4rz2A:
3.9		 5kprA-4rz2A:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4rz2 SITE-DETERMINING
PROTEIN
(Geobacillus
thermodenitrific
ans) 		3 / 3 MET A 258
GLN A 257
ARG A 256
 None
 1.05A 5m35B-4rz2A:
undetectable		 5m35B-4rz2A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4rz2 SITE-DETERMINING
PROTEIN
(Geobacillus
thermodenitrific
ans) 		3 / 3 MET A 258
GLN A 257
ARG A 256
 None
 1.07A 5m36A-4rz2A:
undetectable		 5m36A-4rz2A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4rz2 SITE-DETERMINING
PROTEIN
(Geobacillus
thermodenitrific
ans) 		3 / 3 MET A 258
GLN A 257
ARG A 256
 None
 1.07A 6fn9A-4rz2A:
undetectable		 6fn9A-4rz2A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4rz2 SITE-DETERMINING
PROTEIN
(Geobacillus
thermodenitrific
ans) 		3 / 3 MET A 258
GLN A 257
ARG A 256
 None
 1.08A 6fnaB-4rz2A:
undetectable		 6fnaB-4rz2A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4rz2 SITE-DETERMINING
PROTEIN
(Geobacillus
thermodenitrific
ans) 		3 / 3 MET A 258
GLN A 257
ARG A 256
 None
 1.06A 6fnbA-4rz2A:
undetectable		 6fnbA-4rz2A:
21.82