SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rz9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 4rz9 PRE-MRNA-SPLICING
FACTOR 38A
(Homo
sapiens) 		5 / 12 PHE A 147
LEU A 151
LEU A 102
THR A  68
ILE A 160
 None
 1.05A 1mx8A-4rz9A:
undetectable		 1mx8A-4rz9A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 4rz9 PRE-MRNA-SPLICING
FACTOR 38A
(Homo
sapiens) 		5 / 12 THR A 110
GLY A 103
ILE A 148
PHE A 147
TYR A 124
 None
 1.36A 1oltA-4rz9A:
undetectable		 1oltA-4rz9A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 4rz9 PRE-MRNA-SPLICING
FACTOR 38A
(Homo
sapiens) 		4 / 6 LEU A 123
ASP A 126
ILE A 130
ARG A 128
 None
 0.99A 2rlfA-4rz9A:
undetectable
2rlfB-4rz9A:
undetectable		 2rlfA-4rz9A:
11.18
2rlfB-4rz9A:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 4rz9 PRE-MRNA-SPLICING
FACTOR 38A
(Homo
sapiens) 		4 / 6 LEU A 123
ASP A 126
ILE A 130
ARG A 128
 None
 0.92A 2rlfC-4rz9A:
undetectable
2rlfD-4rz9A:
undetectable		 2rlfC-4rz9A:
11.18
2rlfD-4rz9A:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 4rz9 PRE-MRNA-SPLICING
FACTOR 38A
(Homo
sapiens) 		4 / 8 ASP A 126
ARG A 128
LYS A  97
VAL A 157
 None
 1.22A 6fbvD-4rz9A:
undetectable		 6fbvD-4rz9A:
9.05