SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rza'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 4rza PRE-MRNA-SPLICING
FACTOR 38A
(Homo
sapiens) 		5 / 12 PHE A 147
LEU A 151
LEU A 102
THR A  68
ILE A 160
 None
 1.02A 1mx8A-4rzaA:
undetectable		 1mx8A-4rzaA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4rza PRE-MRNA-SPLICING
FACTOR 38A
(Homo
sapiens) 		5 / 12 ILE A  91
ASP A 115
GLY A 111
LEU A 105
LEU A 151
 None
 1.11A 1rjdA-4rzaA:
undetectable		 1rjdA-4rzaA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4rza PRE-MRNA-SPLICING
FACTOR 38A
(Homo
sapiens) 		5 / 12 ILE A  91
ASP A 115
GLY A 111
LEU A 105
LEU A 151
 None
 1.09A 1rjdC-4rzaA:
undetectable		 1rjdC-4rzaA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 4rza PRE-MRNA-SPLICING
FACTOR 38A
(Homo
sapiens) 		4 / 4 LEU A  78
PRO A  17
LEU A  20
ARG A 108
 None
 1.29A 2hrcB-4rzaA:
undetectable		 2hrcB-4rzaA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 4rza PRE-MRNA-SPLICING
FACTOR 38A
(Homo
sapiens) 		5 / 11 LEU A 102
ILE A 130
LYS A 131
SER A 132
THR A  68
 None
 1.28A 3bjwH-4rzaA:
undetectable		 3bjwH-4rzaA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 4rza PRE-MRNA-SPLICING
FACTOR 38A
(Homo
sapiens) 		4 / 7 THR A  74
LEU A 120
LYS A 118
GLU A  94
 None
 1.08A 5tudA-4rzaA:
undetectable		 5tudA-4rzaA:
18.51