SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rzc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)		 4rzc FV M6P-1 LIGHT CHAIN
FV M6P-1 HEAVY CHAIN
(Oryctolagus
cuniculus;
Oryctolagus
cuniculus) 		4 / 8 PHE L  98
TYR H 100
GLY H  99
GLY H 100
 None
 0.90A 1ekjE-4rzcL:
undetectable
1ekjF-4rzcL:
undetectable		 1ekjE-4rzcL:
20.09
1ekjF-4rzcL:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4rzc FV M6P-1 HEAVY CHAIN
FV M6P-1 LIGHT CHAIN
(Oryctolagus
cuniculus) 		4 / 8 TYR H 100
GLY H  99
VAL L  28
PHE L  98
 None
 1.12A 1gsfA-4rzcH:
undetectable		 1gsfA-4rzcH:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4rzc FV M6P-1 HEAVY CHAIN
FV M6P-1 LIGHT CHAIN
(Oryctolagus
cuniculus) 		4 / 8 TYR H 100
GLY H  99
VAL L  28
PHE L  98
 None
 1.12A 1gsfB-4rzcH:
undetectable		 1gsfB-4rzcH:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4rzc FV M6P-1 HEAVY CHAIN
FV M6P-1 LIGHT CHAIN
(Oryctolagus
cuniculus) 		4 / 8 TYR H 100
GLY H  99
VAL L  28
PHE L  98
 None
 1.12A 1gsfD-4rzcH:
undetectable		 1gsfD-4rzcH:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 4rzc FV M6P-1 HEAVY CHAIN
FV M6P-1 LIGHT CHAIN
(Oryctolagus
cuniculus) 		6 / 12 TYR L  36
PHE L  98
ASN H  35
VAL H  37
ALA H  93
TRP H 103
 None
 0.65A 1h8sA-4rzcL:
18.6		 1h8sA-4rzcL:
29.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGL_L_ESTL911_1
(IG GAMMA-1-CHAIN
IG KAPPA-CHAIN)		 4rzc FV M6P-1 HEAVY CHAIN
(Oryctolagus
cuniculus) 		5 / 10 ALA L  34
TYR L  36
LEU L  46
TYR L  49
HIS L  89
 None
 0.66A 1jglH-4rzcL:
16.3
1jglL-4rzcL:
18.9		 1jglH-4rzcL:
25.54
1jglL-4rzcL:
31.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNN_H_ESTH350_1
(MONOCLONAL
ANTI-ESTRADIOL
17E12E5
IMMUNOGLOBULIN
GAMMA-1 CHAIN
MONOCLONAL
ANTI-ESTRADIOL
17E12E5
IMMUNOGLOBULIN KAPPA
CHAIN)		 4rzc FV M6P-1 HEAVY CHAIN
(Oryctolagus
cuniculus) 		5 / 10 TYR L  36
LEU L  46
TYR L  49
HIS L  89
TYR L  96
 None
 0.66A 1jnnH-4rzcL:
15.7
1jnnL-4rzcL:
19.0		 1jnnH-4rzcL:
22.40
1jnnL-4rzcL:
35.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 4rzc FV M6P-1 HEAVY CHAIN
(Oryctolagus
cuniculus) 		4 / 4 HIS L  89
ALA L  34
PHE L  71
GLY L  90
 None
 1.33A 1mj2B-4rzcL:
undetectable		 1mj2B-4rzcL:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 4rzc FV M6P-1 HEAVY CHAIN
(Oryctolagus
cuniculus) 		4 / 4 HIS L  89
ALA L  34
PHE L  71
GLY L  90
 None
 1.31A 1mj2D-4rzcL:
undetectable		 1mj2D-4rzcL:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 4rzc FV M6P-1 HEAVY CHAIN
(Oryctolagus
cuniculus) 		4 / 4 HIS L  89
ALA L  34
PHE L  71
GLY L  90
 None
 1.33A 1mjoB-4rzcL:
undetectable		 1mjoB-4rzcL:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 4rzc FV M6P-1 HEAVY CHAIN
(Oryctolagus
cuniculus) 		4 / 4 HIS L  89
ALA L  34
PHE L  71
GLY L  90
 None
 1.41A 1mjoA-4rzcL:
undetectable		 1mjoA-4rzcL:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 4rzc FV M6P-1 HEAVY CHAIN
(Oryctolagus
cuniculus) 		4 / 4 HIS L  89
ALA L  34
PHE L  71
GLY L  90
 None
 1.31A 1mjoD-4rzcL:
undetectable		 1mjoD-4rzcL:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 4rzc FV M6P-1 HEAVY CHAIN
(Oryctolagus
cuniculus) 		4 / 7 PRO L  44
TYR L  87
HIS L  89
TYR L  36
 None
 1.15A 2ombC-4rzcL:
18.6
2ombD-4rzcL:
18.3		 2ombC-4rzcL:
22.94
2ombD-4rzcL:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 4rzc FV M6P-1 LIGHT CHAIN
(Oryctolagus
cuniculus) 		3 / 3 VAL H  77
ASN H  35
TRP H  47
 None
 1.13A 2y00B-4rzcH:
undetectable		 2y00B-4rzcH:
15.34