SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rzh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 4rzh 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Synechocystis
sp.
PCC
6803) 		4 / 6 ILE A  51
LYS A  20
ALA A  14
VAL A  33
 None
 0.83A 1hk1A-4rzhA:
undetectable		 1hk1A-4rzhA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		 4rzh 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Synechocystis
sp.
PCC
6803) 		4 / 6 ASP A 241
VAL A 245
PRO A 186
THR A 142
 None
 1.32A 2q6oB-4rzhA:
undetectable		 2q6oB-4rzhA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4rzh 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Synechocystis
sp.
PCC
6803) 		5 / 11 ILE A 189
GLY A 212
TYR A 211
GLY A 242
ILE A 206
 None
 1.22A 2y7kA-4rzhA:
undetectable		 2y7kA-4rzhA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4rzh 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 ILE A 189
GLY A 212
TYR A 211
GLY A 242
ILE A 206
 None
 1.17A 2y7kC-4rzhA:
undetectable		 2y7kC-4rzhA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4rzh 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 ILE A 189
GLY A 212
TYR A 211
GLY A 242
ILE A 206
 None
 1.21A 2y7kD-4rzhA:
undetectable		 2y7kD-4rzhA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4rzh 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Synechocystis
sp.
PCC
6803) 		5 / 10 ILE A 189
GLY A 212
TYR A 211
GLY A 242
ILE A 206
 None
 1.23A 2y7pA-4rzhA:
undetectable		 2y7pA-4rzhA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_A_SALA1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4rzh 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Synechocystis
sp.
PCC
6803) 		5 / 9 ILE A 189
GLY A 212
TYR A 211
GLY A 242
ILE A 206
 None
 1.19A 2y7wA-4rzhA:
undetectable		 2y7wA-4rzhA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 4rzh 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 VAL A  71
CYH A 122
MET A 130
ILE A  85
ILE A 139
 None
 1.35A 3g8iA-4rzhA:
undetectable		 3g8iA-4rzhA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA314_0
(UNCHARACTERIZED
PROTEIN)		 4rzh 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 THR A  12
VAL A 163
GLY A 162
LEU A 114
ILE A  94
 None
 1.03A 3ijdA-4rzhA:
2.2		 3ijdA-4rzhA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 4rzh 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Synechocystis
sp.
PCC
6803) 		4 / 5 SER A 143
ILE A  18
TYR A 156
GLY A 187
 None
 0.97A 3uboB-4rzhA:
7.7		 3uboB-4rzhA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 4rzh 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 ALA A  60
VAL A  61
TYR A  37
ALA A 225
ALA A   9
 None
 1.18A 5n5dA-4rzhA:
8.9		 5n5dA-4rzhA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 4rzh 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLY A 118
GLU A  70
VAL A  71
LEU A  74
ILE A  75
 None
 0.92A 6ectA-4rzhA:
5.9		 6ectA-4rzhA:
21.56