SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rzi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 4rzi 3-KETOACYL-ACYL
CARRIER PROTEIN
REDUCTASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 LEU B 232
VAL B 175
ILE B 211
LEU B  28
LEU B  27
 None
 1.14A 1s19A-4rziB:
undetectable		 1s19A-4rziB:
25.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 4rzi 3-KETOACYL-ACYL
CARRIER PROTEIN
REDUCTASE
(Synechocystis
sp.
PCC
6803) 		6 / 11 GLY B  15
ASP B  39
LEU B  40
VAL B  56
ALA B  83
VAL B 105
 None
 0.48A 1uayA-4rziB:
30.9		 1uayA-4rziB:
31.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 4rzi 3-KETOACYL-ACYL
CARRIER PROTEIN
REDUCTASE
(Synechocystis
sp.
PCC
6803) 		6 / 10 GLY B  15
ASP B  39
LEU B  40
VAL B  56
ALA B  83
VAL B 105
 None
 0.49A 1uayB-4rziB:
31.5		 1uayB-4rziB:
31.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4rzi 3-KETOACYL-ACYL
CARRIER PROTEIN
REDUCTASE
(Synechocystis
sp.
PCC
6803) 		3 / 3 ASN B  82
ILE B 129
MET B 157
 None
 0.83A 2h42C-4rziB:
undetectable		 2h42C-4rziB:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 4rzi 3-KETOACYL-ACYL
CARRIER PROTEIN
REDUCTASE
(Synechocystis
sp.
PCC
6803) 		5 / 10 LEU B   6
ALA B 212
VAL B  80
ILE B  11
VAL B  35
 None
 1.04A 2nnjA-4rziB:
undetectable		 2nnjA-4rziB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA802_1
(TRANSPORTER)		 4rzi 3-KETOACYL-ACYL
CARRIER PROTEIN
REDUCTASE
(Synechocystis
sp.
PCC
6803) 		4 / 6 ILE B 135
SER B 136
ILE B 188
PHE B 205
 None
 1.06A 2q72A-4rziB:
undetectable		 2q72A-4rziB:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4rzi 3-KETOACYL-ACYL
CARRIER PROTEIN
REDUCTASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 ILE B  24
ALA B  23
GLY B  19
ILE B 211
GLY B  15
 None
 0.80A 2qe6A-4rziB:
6.0		 2qe6A-4rziB:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 4rzi 3-KETOACYL-ACYL
CARRIER PROTEIN
REDUCTASE
(Synechocystis
sp.
PCC
6803) 		4 / 6 LEU B  50
SER B  61
ASP B  58
GLU B  68
 None
 1.19A 2vn1B-4rziB:
undetectable		 2vn1B-4rziB:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4rzi 3-KETOACYL-ACYL
CARRIER PROTEIN
REDUCTASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 VAL B  12
SER B 113
THR B  57
ASN B  55
ALA B  65
 None
 0.99A 2x2iA-4rziB:
undetectable		 2x2iA-4rziB:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4rzi 3-KETOACYL-ACYL
CARRIER PROTEIN
REDUCTASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 VAL B  12
SER B 113
THR B  57
ASN B  55
ALA B  65
 None
 1.08A 2x2iC-4rziB:
undetectable		 2x2iC-4rziB:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z97_A_CAMA422_0
(CYTOCHROME P450-CAM)		 4rzi 3-KETOACYL-ACYL
CARRIER PROTEIN
REDUCTASE
(Synechocystis
sp.
PCC
6803) 		4 / 6 TYR B  77
LEU B   6
VAL B 130
VAL B  80
 None
 0.99A 2z97A-4rziB:
undetectable		 2z97A-4rziB:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 4rzi 3-KETOACYL-ACYL
CARRIER PROTEIN
REDUCTASE
(Synechocystis
sp.
PCC
6803) 		4 / 5 VAL B  10
VAL B  76
PHE B  37
ARG B 171
 None
 1.29A 3bjwB-4rziB:
undetectable		 3bjwB-4rziB:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 4rzi 3-KETOACYL-ACYL
CARRIER PROTEIN
REDUCTASE
(Synechocystis
sp.
PCC
6803) 		5 / 11 LEU B  27
LEU B 219
ALA B 216
VAL B  35
LYS B   9
 None
 1.04A 3e22B-4rziB:
6.1		 3e22B-4rziB:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)		 4rzi 3-KETOACYL-ACYL
CARRIER PROTEIN
REDUCTASE
(Synechocystis
sp.
PCC
6803) 		5 / 11 LEU B  27
LEU B 219
ALA B 216
VAL B  35
LYS B   9
 None
 1.07A 3e22D-4rziB:
6.4		 3e22D-4rziB:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 4rzi 3-KETOACYL-ACYL
CARRIER PROTEIN
REDUCTASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLY B  15
GLY B  16
ALA B  22
ALA B  41
ILE B  20
 None
 0.95A 3jayA-4rziB:
undetectable		 3jayA-4rziB:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4rzi 3-KETOACYL-ACYL
CARRIER PROTEIN
REDUCTASE
(Synechocystis
sp.
PCC
6803) 		5 / 10 ILE B 196
PHE B 205
ILE B 200
ILE B 135
SER B 134
 None
 1.24A 3o1xA-4rziB:
undetectable		 3o1xA-4rziB:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 4rzi 3-KETOACYL-ACYL
CARRIER PROTEIN
REDUCTASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 LYS B 207
ASP B 181
ILE B 180
GLY B 236
PHE B 202
 None
 1.27A 3ps9A-4rziB:
2.7		 3ps9A-4rziB:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4rzi 3-KETOACYL-ACYL
CARRIER PROTEIN
REDUCTASE
(Synechocystis
sp.
PCC
6803) 		5 / 10 ILE B 196
PHE B 205
ILE B 200
ILE B 135
SER B 134
 None
 1.24A 3qgzA-4rziB:
undetectable		 3qgzA-4rziB:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 4rzi 3-KETOACYL-ACYL
CARRIER PROTEIN
REDUCTASE
(Synechocystis
sp.
PCC
6803) 		3 / 3 THR B 197
ASP B 181
GLU B 210
 None
 0.80A 3qowA-4rziB:
2.2		 3qowA-4rziB:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 4rzi 3-KETOACYL-ACYL
CARRIER PROTEIN
REDUCTASE
(Synechocystis
sp.
PCC
6803) 		4 / 5 SER B 134
ILE B  20
TYR B 147
GLY B 178
 None
 1.02A 3uboB-4rziB:
6.7		 3uboB-4rziB:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4rzi 3-KETOACYL-ACYL
CARRIER PROTEIN
REDUCTASE
(Synechocystis
sp.
PCC
6803) 		3 / 3 LYS B  26
GLU B  30
TRP B 213
 None
 0.96A 3v4tH-4rziB:
undetectable		 3v4tH-4rziB:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)		 4rzi 3-KETOACYL-ACYL
CARRIER PROTEIN
REDUCTASE
(Synechocystis
sp.
PCC
6803) 		5 / 11 ILE B  24
ILE B  20
GLY B  19
VAL B 234
GLY B 206
 None
 1.07A 4ac9B-4rziB:
6.4
4ac9C-4rziB:
6.1		 4ac9B-4rziB:
20.61
4ac9C-4rziB:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 4rzi 3-KETOACYL-ACYL
CARRIER PROTEIN
REDUCTASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 VAL B 154
GLY B  84
ALA B  83
THR B  14
VAL B  79
 None
 1.03A 4xdrA-4rziB:
undetectable		 4xdrA-4rziB:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 4rzi 3-KETOACYL-ACYL
CARRIER PROTEIN
REDUCTASE
(Synechocystis
sp.
PCC
6803) 		3 / 3 THR B 197
ASP B 181
GLU B 210
 None
 0.71A 5fa8A-4rziB:
5.7		 5fa8A-4rziB:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4rzi 3-KETOACYL-ACYL
CARRIER PROTEIN
REDUCTASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 ALA B  33
LEU B 219
VAL B 110
LEU B  27
ALA B 212
 None
 1.11A 6djzC-4rziB:
undetectable		 6djzC-4rziB:
23.77