SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rzk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_2
(POL POLYPROTEIN)		 4rzk SMALL HEAT SHOCK
PROTEIN HSP20 FAMILY
(Sulfolobus
solfataricus) 		5 / 12 LEU A 121
ALA A  87
ILE A  90
PRO A 139
ILE A 136
 None
 0.87A 2f80B-4rzkA:
undetectable		 2f80B-4rzkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_2
(POL POLYPROTEIN)		 4rzk SMALL HEAT SHOCK
PROTEIN HSP20 FAMILY
(Sulfolobus
solfataricus) 		5 / 12 LEU A 121
ALA A  87
ILE A  90
PRO A 139
ILE A 136
 None
 0.87A 2f81B-4rzkA:
undetectable		 2f81B-4rzkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_2
(PROTEASE)		 4rzk SMALL HEAT SHOCK
PROTEIN HSP20 FAMILY
(Sulfolobus
solfataricus) 		5 / 12 LEU A 121
ALA A  87
ILE A  90
PRO A 139
ILE A 136
 None
 0.91A 2nmyB-4rzkA:
undetectable		 2nmyB-4rzkA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_1
(PROTEASE)		 4rzk SMALL HEAT SHOCK
PROTEIN HSP20 FAMILY
(Sulfolobus
solfataricus) 		5 / 12 LEU A 121
ALA A  87
ILE A  90
PRO A 139
LEU A 138
 None
 0.88A 2o4nA-4rzkA:
undetectable		 2o4nA-4rzkA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_2
(HIV-1 PROTEASE)		 4rzk SMALL HEAT SHOCK
PROTEIN HSP20 FAMILY
(Sulfolobus
solfataricus) 		5 / 12 LEU A 121
ALA A  87
ILE A  90
PRO A 139
ILE A 136
 None
 0.86A 3cywB-4rzkA:
undetectable		 3cywB-4rzkA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_2
(HIV-1 PROTEASE)		 4rzk SMALL HEAT SHOCK
PROTEIN HSP20 FAMILY
(Sulfolobus
solfataricus) 		5 / 12 LEU A 121
ALA A  87
ILE A  90
PRO A 139
ILE A 136
 None
 0.81A 3d1zB-4rzkA:
undetectable		 3d1zB-4rzkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_2
(PROTEASE)		 4rzk SMALL HEAT SHOCK
PROTEIN HSP20 FAMILY
(Sulfolobus
solfataricus) 		5 / 10 LEU A 121
ALA A  87
ILE A  90
PRO A 139
ILE A 136
 None
 0.92A 3ekpB-4rzkA:
undetectable		 3ekpB-4rzkA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_1
(PROTEASE)		 4rzk SMALL HEAT SHOCK
PROTEIN HSP20 FAMILY
(Sulfolobus
solfataricus) 		5 / 10 LEU A 121
ALA A  87
ILE A  90
PRO A 139
ILE A 136
 None
 0.95A 3ekpC-4rzkA:
undetectable		 3ekpC-4rzkA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_1
(PROTEASE)		 4rzk SMALL HEAT SHOCK
PROTEIN HSP20 FAMILY
(Sulfolobus
solfataricus) 		5 / 11 LEU A 121
ALA A  87
ILE A  90
PRO A 139
ILE A 136
 None
 0.89A 3ektC-4rzkA:
undetectable		 3ektC-4rzkA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_2
(PROTEASE)		 4rzk SMALL HEAT SHOCK
PROTEIN HSP20 FAMILY
(Sulfolobus
solfataricus) 		5 / 11 LEU A 121
ALA A  87
ILE A  90
PRO A 139
ILE A 136
 None
 0.91A 3ektD-4rzkA:
undetectable		 3ektD-4rzkA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_1
(HIV-1 PROTEASE)		 4rzk SMALL HEAT SHOCK
PROTEIN HSP20 FAMILY
(Sulfolobus
solfataricus) 		5 / 12 LEU A 121
ALA A  87
ILE A  90
PRO A 139
ILE A 136
 None
 0.92A 3lzsA-4rzkA:
undetectable		 3lzsA-4rzkA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_2
(HIV-1 PROTEASE)		 4rzk SMALL HEAT SHOCK
PROTEIN HSP20 FAMILY
(Sulfolobus
solfataricus) 		5 / 12 LEU A 121
ALA A  87
ILE A  90
PRO A 139
ILE A 136
 None
 0.96A 3lzsB-4rzkA:
undetectable		 3lzsB-4rzkA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_1
(HIV-1 PROTEASE)		 4rzk SMALL HEAT SHOCK
PROTEIN HSP20 FAMILY
(Sulfolobus
solfataricus) 		5 / 12 LEU A 121
ALA A  87
ILE A  90
PRO A 139
ILE A 136
 None
 0.96A 3lzuA-4rzkA:
undetectable		 3lzuA-4rzkA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_2
(HIV-1 PROTEASE)		 4rzk SMALL HEAT SHOCK
PROTEIN HSP20 FAMILY
(Sulfolobus
solfataricus) 		5 / 12 LEU A 121
ALA A  87
ILE A  90
PRO A 139
ILE A 136
 None
 0.91A 3mwsB-4rzkA:
undetectable		 3mwsB-4rzkA:
25.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 4rzk SMALL HEAT SHOCK
PROTEIN HSP20 FAMILY
(Sulfolobus
solfataricus) 		5 / 12 GLY A 104
GLY A 154
ASP A 129
SER A 127
GLU A  81
 None
 1.02A 3tkaA-4rzkA:
undetectable		 3tkaA-4rzkA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_1
(POL POLYPROTEIN)		 4rzk SMALL HEAT SHOCK
PROTEIN HSP20 FAMILY
(Sulfolobus
solfataricus) 		5 / 9 LEU A 121
ALA A  87
ILE A  90
PRO A 139
LEU A 138
 None
 0.94A 3u7sA-4rzkA:
undetectable		 3u7sA-4rzkA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4rzk SMALL HEAT SHOCK
PROTEIN HSP20 FAMILY
(Sulfolobus
solfataricus) 		3 / 3 THR A 124
VAL A 122
GLU A  82
 None
 0.54A 3v4tA-4rzkA:
undetectable
3v4tD-4rzkA:
undetectable		 3v4tA-4rzkA:
13.59
3v4tD-4rzkA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_2
(PROTEASE)		 4rzk SMALL HEAT SHOCK
PROTEIN HSP20 FAMILY
(Sulfolobus
solfataricus) 		5 / 11 LEU A 121
ALA A  87
ILE A  90
PRO A 139
ILE A 136
 None
 0.86A 4hlaB-4rzkA:
undetectable		 4hlaB-4rzkA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_2
(PROTEASE)		 4rzk SMALL HEAT SHOCK
PROTEIN HSP20 FAMILY
(Sulfolobus
solfataricus) 		5 / 10 LEU A 121
ALA A  87
ILE A  90
PRO A 139
ILE A 136
 None
 1.05A 4njuB-4rzkA:
undetectable		 4njuB-4rzkA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_1
(PROTEASE)		 4rzk SMALL HEAT SHOCK
PROTEIN HSP20 FAMILY
(Sulfolobus
solfataricus) 		5 / 12 LEU A 121
ALA A  87
ILE A  90
PRO A 139
ILE A 136
 None
 0.87A 5t8hA-4rzkA:
undetectable		 5t8hA-4rzkA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_0
(PROTEASE)		 4rzk SMALL HEAT SHOCK
PROTEIN HSP20 FAMILY
(Sulfolobus
solfataricus) 		5 / 12 LEU A 121
ALA A  87
ILE A  90
PRO A 139
ILE A 136
 None
 0.89A 6dgxA-4rzkA:
undetectable		 6dgxA-4rzkA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_0
(PROTEASE)		 4rzk SMALL HEAT SHOCK
PROTEIN HSP20 FAMILY
(Sulfolobus
solfataricus) 		5 / 12 LEU A 121
ALA A  87
ILE A  90
PRO A 139
ILE A 136
 None
 0.88A 6dh3A-4rzkA:
undetectable		 6dh3A-4rzkA:
25.77