SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rzl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 4rzl RESTRICTION
ENDONUCLEASE LPNPI
(Legionella
pneumophila) 		4 / 6 LEU A   9
GLY A  22
SER A 138
ILE A   3
 None
 0.97A 1yajF-4rzlA:
undetectable		 1yajF-4rzlA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4rzl RESTRICTION
ENDONUCLEASE LPNPI
(Legionella
pneumophila) 		5 / 12 LEU A 107
LEU A  60
PHE A 125
LEU A 203
TYR A 207
 None
None
None
None
1PE  A 301 (-3.6A)
 1.50A 3adsA-4rzlA:
undetectable		 3adsA-4rzlA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)		 4rzl RESTRICTION
ENDONUCLEASE LPNPI
(Legionella
pneumophila) 		4 / 6 GLY A  78
GLN A  79
ILE A 219
VAL A 217
 None
 1.08A 3kvvF-4rzlA:
undetectable		 3kvvF-4rzlA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_1
(PROTEASE)		 4rzl RESTRICTION
ENDONUCLEASE LPNPI
(Legionella
pneumophila) 		6 / 9 ILE A 190
VAL A 185
GLY A 143
ILE A 126
ILE A  40
ILE A  37
 None
 1.44A 3s43A-4rzlA:
undetectable		 3s43A-4rzlA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_F_URFF1301_1
(URIDINE
PHOSPHORYLASE)		 4rzl RESTRICTION
ENDONUCLEASE LPNPI
(Legionella
pneumophila) 		4 / 6 GLY A  78
GLN A  79
ILE A 219
VAL A 217
 None
 1.05A 4e1vF-4rzlA:
undetectable		 4e1vF-4rzlA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 4rzl RESTRICTION
ENDONUCLEASE LPNPI
(Legionella
pneumophila) 		4 / 8 ILE A  16
ASP A  17
GLY A  78
THR A  75
 None
 0.93A 5hwaA-4rzlA:
undetectable		 5hwaA-4rzlA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_A_SAMA601_0
(NS5 MTASE)		 4rzl RESTRICTION
ENDONUCLEASE LPNPI
(Legionella
pneumophila) 		6 / 12 GLY A 100
GLY A  45
THR A 103
LYS A 105
HIS A  94
ASP A 109
 None
 1.43A 5wz2A-4rzlA:
undetectable		 5wz2A-4rzlA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4rzl RESTRICTION
ENDONUCLEASE LPNPI
(Legionella
pneumophila) 		4 / 8 ILE A  81
GLN A  79
ILE A 159
THR A 155
 None
 1.05A 6cduG-4rzlA:
undetectable
6cduH-4rzlA:
undetectable		 6cduG-4rzlA:
21.98
6cduH-4rzlA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 4rzl RESTRICTION
ENDONUCLEASE LPNPI
(Legionella
pneumophila) 		4 / 7 PHE A  80
LEU A  60
GLY A  84
GLY A  67
 None
 0.77A 6eu9D-4rzlA:
undetectable		 6eu9D-4rzlA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 4rzl RESTRICTION
ENDONUCLEASE LPNPI
(Legionella
pneumophila) 		5 / 12 PRO A 123
ILE A 124
VAL A 146
ILE A  40
PHE A 141
 None
 1.32A 6j21A-4rzlA:
undetectable		 6j21A-4rzlA:
17.01