SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rzm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 4rzm EPOXIDE HYDROLASE
LASB
(Streptomyces
lasaliensis) 		4 / 8 LEU A 161
VAL A 257
GLY A 261
TYR A 162
 None
 1.01A 1jlfA-4rzmA:
undetectable
1jlfB-4rzmA:
undetectable		 1jlfA-4rzmA:
19.76
1jlfB-4rzmA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 4rzm EPOXIDE HYDROLASE
LASB
(Streptomyces
lasaliensis) 		5 / 11 ALA A  83
ARG A 101
ARG A  99
VAL A  63
LEU A  36
 FMT  A 303 ( 4.3A)
None
None
None
None
 1.12A 1n4hA-4rzmA:
undetectable		 1n4hA-4rzmA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 4rzm EPOXIDE HYDROLASE
LASB
(Streptomyces
lasaliensis) 		4 / 4 THR A  42
GLY A 208
ASP A 135
ALA A 204
 None
 1.20A 1sg9A-4rzmA:
undetectable		 1sg9A-4rzmA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 4rzm EPOXIDE HYDROLASE
LASB
(Streptomyces
lasaliensis) 		3 / 3 ASP A 207
GLU A 116
ARG A  54
 None
 0.86A 1wopA-4rzmA:
undetectable		 1wopA-4rzmA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4rzm EPOXIDE HYDROLASE
LASB
(Streptomyces
lasaliensis) 		4 / 4 TYR A 162
LEU A 180
LEU A 183
HIS A 146
 None
None
None
GOL  A 302 (-4.1A)
 1.46A 2x7hB-4rzmA:
undetectable		 2x7hB-4rzmA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)		 4rzm EPOXIDE HYDROLASE
LASB
(Streptomyces
lasaliensis) 		5 / 12 LEU A 233
MET A 219
ILE A 247
GLY A 225
LEU A 227
 None
LSD  A 301 ( 4.1A)
None
None
LSD  A 301 ( 4.6A)
 1.19A 2yjaB-4rzmA:
undetectable		 2yjaB-4rzmA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 4rzm EPOXIDE HYDROLASE
LASB
(Streptomyces
lasaliensis) 		3 / 3 TYR A 269
GLU A 116
ASP A  33
 None
 0.86A 3bxoB-4rzmA:
2.0		 3bxoB-4rzmA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4rzm EPOXIDE HYDROLASE
LASB
(Streptomyces
lasaliensis) 		4 / 7 GLY A 256
TYR A 269
VAL A 172
ARG A 118
 None
 0.86A 3elzA-4rzmA:
1.3		 3elzA-4rzmA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4rzm EPOXIDE HYDROLASE
LASB
(Streptomyces
lasaliensis) 		4 / 7 TYR A 162
TYR A 251
VAL A 215
LEU A 158
 None
LSD  A 301 ( 3.8A)
None
None
 0.87A 3elzA-4rzmA:
1.3		 3elzA-4rzmA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_2
(HIV-1 PROTEASE)		 4rzm EPOXIDE HYDROLASE
LASB
(Streptomyces
lasaliensis) 		4 / 7 ARG A  17
VAL A 102
GLY A 104
ILE A 106
 None
None
FMT  A 303 ( 4.1A)
None
 0.82A 3ufnB-4rzmA:
undetectable		 3ufnB-4rzmA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 4rzm EPOXIDE HYDROLASE
LASB
(Streptomyces
lasaliensis) 		4 / 6 ARG A 209
ARG A 167
VAL A 257
ASP A 264
 None
 1.27A 4xqeA-4rzmA:
undetectable		 4xqeA-4rzmA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 4rzm EPOXIDE HYDROLASE
LASB
(Streptomyces
lasaliensis) 		4 / 6 ARG A 209
ARG A 167
VAL A 257
ASP A 264
 None
 1.27A 4xqeB-4rzmA:
undetectable		 4xqeB-4rzmA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4rzm EPOXIDE HYDROLASE
LASB
(Streptomyces
lasaliensis) 		5 / 9 LEU A 233
MET A 234
MET A 219
GLY A 225
LEU A 227
 None
None
LSD  A 301 ( 4.1A)
None
LSD  A 301 ( 4.6A)
 1.31A 5wgqA-4rzmA:
undetectable		 5wgqA-4rzmA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 4rzm EPOXIDE HYDROLASE
LASB
(Streptomyces
lasaliensis) 		4 / 7 ALA A 199
GLY A 200
LEU A 201
TYR A  71
 None
 0.55A 6nm4A-4rzmA:
undetectable		 6nm4A-4rzmA:
21.55