SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rzp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_1
(STRUCTURAL PROTEIN
VP3)		 4rzp ENGINEERED PROTEIN
OR366
(synthetic
construct) 		3 / 3 GLU A  77
ASP A  42
ASP A  84
 None
 0.76A 3jb2A-4rzpA:
2.0		 3jb2A-4rzpA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 4rzp ENGINEERED PROTEIN
OR366
(synthetic
construct) 		6 / 12 GLY A  32
VAL A  82
GLY A  74
SER A  73
ALA A  69
ALA A 109
 None
 1.46A 3keeB-4rzpA:
undetectable		 3keeB-4rzpA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 4rzp ENGINEERED PROTEIN
OR366
(synthetic
construct) 		5 / 12 GLY A 158
ASN A 159
LEU A 194
ALA A 235
ALA A 198
 None
 1.12A 4uckB-4rzpA:
undetectable		 4uckB-4rzpA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4rzp ENGINEERED PROTEIN
OR366
(synthetic
construct) 		4 / 4 GLN A  19
THR A  12
GLU A  51
LEU A  68
 None
 1.50A 5m66A-4rzpA:
undetectable		 5m66A-4rzpA:
19.05