SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rzz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 4rzz PEPTIDASE M24
(Ruegeria
lacuscaerulensis) 		3 / 3 GLU A 261
ILE A 299
ARG A 204
 None
 0.79A 1cd2A-4rzzA:
undetectable		 1cd2A-4rzzA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 4rzz PEPTIDASE M24
(Ruegeria
lacuscaerulensis) 		5 / 11 GLY A 208
PRO A 209
GLU A 211
ASP A  88
ILE A 299
 None
 1.17A 1jzsA-4rzzA:
undetectable		 1jzsA-4rzzA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 4rzz PEPTIDASE M24
(Ruegeria
lacuscaerulensis) 		4 / 5 ASP A  53
LEU A  19
GLY A  22
ARG A  29
 None
 1.10A 2j2pA-4rzzA:
undetectable
2j2pB-4rzzA:
undetectable		 2j2pA-4rzzA:
17.96
2j2pB-4rzzA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1291_1
(FICOLIN-2)		 4rzz PEPTIDASE M24
(Ruegeria
lacuscaerulensis) 		4 / 4 ASP A  53
LEU A  19
GLY A  22
ARG A  29
 None
 1.11A 2j2pD-4rzzA:
undetectable
2j2pE-4rzzA:
undetectable		 2j2pD-4rzzA:
17.96
2j2pE-4rzzA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4rzz PEPTIDASE M24
(Ruegeria
lacuscaerulensis) 		4 / 7 ILE A 292
LEU A 268
PHE A 294
LEU A 420
 None
 0.78A 3adxA-4rzzA:
undetectable		 3adxA-4rzzA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 4rzz PEPTIDASE M24
(Ruegeria
lacuscaerulensis) 		5 / 9 VAL A 104
ARG A 102
SER A  89
ILE A  67
GLY A 110
 None
 1.15A 3cv9A-4rzzA:
undetectable		 3cv9A-4rzzA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		 4rzz PEPTIDASE M24
(Ruegeria
lacuscaerulensis) 		5 / 9 ILE A 299
ILE A 304
LEU A 375
GLU A 378
LEU A  81
 None
 1.45A 3f78A-4rzzA:
undetectable		 3f78A-4rzzA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_B_ICFB2_1
(INTEGRIN ALPHA-L)		 4rzz PEPTIDASE M24
(Ruegeria
lacuscaerulensis) 		5 / 9 ILE A 299
ILE A 304
LEU A 375
GLU A 378
LEU A  81
 None
 1.43A 3f78B-4rzzA:
undetectable		 3f78B-4rzzA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 4rzz PEPTIDASE M24
(Ruegeria
lacuscaerulensis) 		4 / 8 THR A  64
GLY A  74
LEU A 106
LEU A 105
 None
 0.76A 3nbqB-4rzzA:
undetectable		 3nbqB-4rzzA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 4rzz PEPTIDASE M24
(Ruegeria
lacuscaerulensis) 		4 / 8 THR A  64
GLY A  74
LEU A 106
LEU A 105
 None
 0.81A 3nbqC-4rzzA:
undetectable		 3nbqC-4rzzA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 4rzz PEPTIDASE M24
(Ruegeria
lacuscaerulensis) 		4 / 8 HIS A 170
GLY A  73
TYR A  72
GLU A 192
 None
 0.90A 3u9hA-4rzzA:
undetectable		 3u9hA-4rzzA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 4rzz PEPTIDASE M24
(Ruegeria
lacuscaerulensis) 		3 / 3 TYR A 366
ASP A 307
ASP A 422
 PO4  A 503 (-4.5A)
FE  A 502 (-2.3A)
None
 0.74A 4a6eA-4rzzA:
undetectable		 4a6eA-4rzzA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 4rzz PEPTIDASE M24
(Ruegeria
lacuscaerulensis) 		4 / 5 HIS A 170
GLY A  73
TYR A  72
GLU A 192
 None
 1.12A 4ae1B-4rzzA:
undetectable		 4ae1B-4rzzA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 4rzz PEPTIDASE M24
(Ruegeria
lacuscaerulensis) 		5 / 12 GLU A 132
LEU A 162
ILE A  67
GLY A  74
LEU A  76
 None
 1.25A 4j26A-4rzzA:
undetectable		 4j26A-4rzzA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		 4rzz PEPTIDASE M24
(Ruegeria
lacuscaerulensis) 		4 / 8 GLU A 211
ASP A 210
ARG A  54
TRP A  60
 None
 1.12A 4uhxA-4rzzA:
undetectable		 4uhxA-4rzzA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)		 4rzz PEPTIDASE M24
(Ruegeria
lacuscaerulensis) 		4 / 8 GLU A 211
ASP A 210
ARG A  54
TRP A  60
 None
 1.12A 4uhxA-4rzzA:
undetectable		 4uhxA-4rzzA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_C_FOLC201_0
(FOLATE ECF
TRANSPORTER)		 4rzz PEPTIDASE M24
(Ruegeria
lacuscaerulensis) 		5 / 12 ALA A 233
PHE A 294
THR A 311
THR A 296
LEU A 251
 None
 1.43A 4z7fC-4rzzA:
undetectable		 4z7fC-4rzzA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_C_FOLC201_0
(FOLATE ECF
TRANSPORTER)		 4rzz PEPTIDASE M24
(Ruegeria
lacuscaerulensis) 		5 / 12 ARG A 234
ALA A 233
PHE A 294
THR A 311
LEU A 251
 None
 1.35A 4z7fC-4rzzA:
undetectable		 4z7fC-4rzzA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 4rzz PEPTIDASE M24
(Ruegeria
lacuscaerulensis) 		5 / 12 GLY A 110
ASP A 109
ILE A  67
LEU A 129
LEU A 106
 None
 1.12A 5bw4A-4rzzA:
undetectable		 5bw4A-4rzzA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 4rzz PEPTIDASE M24
(Ruegeria
lacuscaerulensis) 		4 / 6 LEU A  76
LEU A 183
PHE A  78
LEU A 139
 None
 0.92A 5gs4A-4rzzA:
undetectable		 5gs4A-4rzzA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 4rzz PEPTIDASE M24
(Ruegeria
lacuscaerulensis) 		4 / 6 ILE A  83
VAL A 130
VAL A 104
SER A 124
 None
 0.91A 5jwaH-4rzzA:
undetectable		 5jwaH-4rzzA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NR3_A_95EA401_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B)		 4rzz PEPTIDASE M24
(Ruegeria
lacuscaerulensis) 		4 / 7 ILE A 247
PHE A 232
ASP A 239
LYS A 241
 None
 1.32A 5nr3A-4rzzA:
undetectable		 5nr3A-4rzzA:
15.75