SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4s05'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4s05 DNA-BINDING
TRANSCRIPTIONAL
REGULATOR BASR
(Klebsiella
pneumoniae) 		5 / 12 LEU A  54
GLU A  35
LEU A  16
LEU A  13
GLY A  29
 None
 1.38A 1d4fD-4s05A:
2.9		 1d4fD-4s05A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		 4s05 DNA-BINDING
TRANSCRIPTIONAL
REGULATOR BASR
(Klebsiella
pneumoniae) 		3 / 3 ASP A   8
LEU A  52
LEU A  54
 MG  A 302 (-2.7A)
None
None
 0.62A 1ikeA-4s05A:
undetectable		 1ikeA-4s05A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 4s05 DNA-BINDING
TRANSCRIPTIONAL
REGULATOR BASR
(Klebsiella
pneumoniae) 		3 / 3 ASP A   8
LEU A  52
LEU A  54
 MG  A 302 (-2.7A)
None
None
 0.67A 1np1B-4s05A:
undetectable		 1np1B-4s05A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 4s05 DNA-BINDING
TRANSCRIPTIONAL
REGULATOR BASR
(Klebsiella
pneumoniae) 		5 / 12 TYR A  98
GLY A  90
THR A  79
SER A  64
ASP A  86
 None
None
BEF  A 301 (-3.7A)
None
None
 0.97A 1nt2A-4s05A:
undetectable		 1nt2A-4s05A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1100_1
(SERUM ALBUMIN)		 4s05 DNA-BINDING
TRANSCRIPTIONAL
REGULATOR BASR
(Klebsiella
pneumoniae) 		4 / 4 LEU A 150
ARG A 133
LEU A 132
ALA A 147
 None
 1.15A 3b9mA-4s05A:
undetectable		 3b9mA-4s05A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4s05 DNA-BINDING
TRANSCRIPTIONAL
REGULATOR BASR
(Klebsiella
pneumoniae) 		4 / 8 ASP A   8
ASP A   9
ASP A  58
ASP A  86
 MG  A 302 (-2.7A)
None
None
None
 1.12A 3havA-4s05A:
undetectable		 3havA-4s05A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4s05 DNA-BINDING
TRANSCRIPTIONAL
REGULATOR BASR
(Klebsiella
pneumoniae) 		4 / 5 LEU A  54
GLY A  59
ILE A  48
VAL A  75
 None
 0.87A 3wriA-4s05A:
undetectable		 3wriA-4s05A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4s05 DNA-BINDING
TRANSCRIPTIONAL
REGULATOR BASR
(Klebsiella
pneumoniae) 		4 / 5 LEU A  54
GLY A  59
ILE A  48
VAL A  75
 None
 0.88A 3wriB-4s05A:
undetectable		 3wriB-4s05A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_2
(PROTEASE)		 4s05 DNA-BINDING
TRANSCRIPTIONAL
REGULATOR BASR
(Klebsiella
pneumoniae) 		5 / 12 GLY A  94
ALA A  95
ILE A  48
THR A  79
ILE A  77
 None
None
None
BEF  A 301 (-3.7A)
None
 1.12A 4njvD-4s05A:
undetectable		 4njvD-4s05A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4s05 DNA-BINDING
TRANSCRIPTIONAL
REGULATOR BASR
(Klebsiella
pneumoniae) 		4 / 6 ALA A  80
THR A  79
VAL A 100
TYR A  98
 BEF  A 301 (-3.5A)
BEF  A 301 (-3.7A)
None
None
 1.05A 5eclA-4s05A:
1.9		 5eclA-4s05A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4s05 DNA-BINDING
TRANSCRIPTIONAL
REGULATOR BASR
(Klebsiella
pneumoniae) 		4 / 6 ALA A  80
THR A  79
VAL A 100
TYR A  98
 BEF  A 301 (-3.5A)
BEF  A 301 (-3.7A)
None
None
 0.94A 5ecoA-4s05A:
2.4		 5ecoA-4s05A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 4s05 DNA-BINDING
TRANSCRIPTIONAL
REGULATOR BASR
(Klebsiella
pneumoniae) 		5 / 11 ARG A 111
GLY A  90
ALA A  95
ILE A  88
ARG A  87
 None
 1.20A 5yk2A-4s05A:
undetectable		 5yk2A-4s05A:
19.96