SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4s0h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 4s0h T-BOX TRANSCRIPTION
FACTOR TBX5
(Homo
sapiens) 		3 / 3 ARG A 134
SER A  86
TYR A  87
 None
 0.73A 1x70A-4s0hA:
undetectable		 1x70A-4s0hA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAZ_A_AINA1202_1
(LACTOTRANSFERRIN)		 4s0h T-BOX TRANSCRIPTION
FACTOR TBX5
(Homo
sapiens) 		3 / 3 GLU A  69
GLY A  71
THR A  72
 None
 0.59A 3iazA-4s0hA:
undetectable		 3iazA-4s0hA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 4s0h T-BOX TRANSCRIPTION
FACTOR TBX5
HOMEOBOX PROTEIN
NKX-2.5
(Homo
sapiens;
Homo
sapiens) 		3 / 3 LYS B 158
ILE A 185
PHE A 201
 None
 0.66A 3j7zS-4s0hB:
undetectable
3j7za-4s0hB:
undetectable		 3j7zS-4s0hB:
23.16
3j7za-4s0hB:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 4s0h HOMEOBOX PROTEIN
NKX-2.5
(Homo
sapiens) 		4 / 6 LEU B 163
GLU B 167
PRO B 166
ARG B 156
 None
 1.39A 3ltwA-4s0hB:
undetectable		 3ltwA-4s0hB:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA617_0
(SERUM ALBUMIN)		 4s0h HOMEOBOX PROTEIN
NKX-2.5
(Homo
sapiens) 		3 / 3 TRP B 185
ARG B 189
LEU B 163
 None
 0.99A 5dbyA-4s0hB:
undetectable		 5dbyA-4s0hB:
6.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4s0h T-BOX TRANSCRIPTION
FACTOR TBX5
(Homo
sapiens) 		4 / 8 LEU A  58
LEU A  63
ILE A 212
THR A  72
 None
 1.05A 5ljbA-4s0hA:
undetectable		 5ljbA-4s0hA:
18.08