SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4s0u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB6_0
(GRAMICIDIN A)		 4s0u RETINOIC ACID EARLY
TRANSCRIPT 1L
PROTEIN
(Homo
sapiens) 		3 / 3 TRP C  49
ALA C  51
VAL C  39
 None
 0.77A 1c4dA-4s0uC:
undetectable
1c4dB-4s0uC:
undetectable		 1c4dA-4s0uC:
6.96
1c4dB-4s0uC:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 4s0u NKG2-D TYPE II
INTEGRAL MEMBRANE
PROTEIN
RETINOIC ACID EARLY
TRANSCRIPT 1L
PROTEIN
(Homo
sapiens;
Homo
sapiens) 		4 / 8 TYR A 152
GLU C  96
VAL C  93
ARG C 156
 None
 1.22A 1s3zA-4s0uA:
undetectable
1s3zB-4s0uA:
undetectable		 1s3zA-4s0uA:
19.05
1s3zB-4s0uA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 4s0u NKG2-D TYPE II
INTEGRAL MEMBRANE
PROTEIN
RETINOIC ACID EARLY
TRANSCRIPT 1L
PROTEIN
(Homo
sapiens;
Homo
sapiens) 		4 / 8 TYR A 152
GLU C  96
VAL C  93
ASP C 189
 None
 1.22A 1s3zA-4s0uA:
undetectable
1s3zB-4s0uA:
undetectable		 1s3zA-4s0uA:
19.05
1s3zB-4s0uA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4s0u NKG2-D TYPE II
INTEGRAL MEMBRANE
PROTEIN
RETINOIC ACID EARLY
TRANSCRIPT 1L
PROTEIN
(Homo
sapiens) 		4 / 7 TRP C 139
TYR A 199
GLU A 201
TYR C 184
 None
 1.25A 2xytH-4s0uC:
undetectable		 2xytH-4s0uC:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 4s0u RETINOIC ACID EARLY
TRANSCRIPT 1L
PROTEIN
(Homo
sapiens) 		3 / 3 HIS C 183
ARG C 156
GLU C 154
 None
 0.84A 3qf1A-4s0uC:
undetectable		 3qf1A-4s0uC:
14.90