SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4s0v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_B_DVAB8_0
(GRAMICIDIN A)		 4s0v HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi) 		3 / 3 VAL A  79
VAL A  75
TRP A  80
 None
 0.92A 1av2A-4s0vA:
undetectable
1av2B-4s0vA:
undetectable		 1av2A-4s0vA:
6.95
1av2B-4s0vA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX9_A_REAA1163_1
(BETA-LACTOGLOBULIN)		 4s0v HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi) 		5 / 11 LEU A1023
ILE A1072
LYS A1094
ILE A1096
VAL A1105
 None
 1.36A 1gx9A-4s0vA:
undetectable		 1gx9A-4s0vA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_1
(NEURAMINIDASE)		 4s0v HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi) 		3 / 3 ARG A 152
ARG A 168
ARG A 299
 None
 0.94A 1l7fA-4s0vA:
undetectable		 1l7fA-4s0vA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		 4s0v HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi) 		3 / 3 ARG A 152
ARG A 168
ARG A 299
 None
 0.95A 1l7hA-4s0vA:
undetectable		 1l7hA-4s0vA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_B_DEXB2999_1
(GLUCOCORTICOID
RECEPTOR)		 4s0v HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi) 		5 / 12 GLY A1032
MET A1029
LEU A1023
ILE A1055
PHE A1064
 None
 1.42A 1p93B-4s0vA:
undetectable		 1p93B-4s0vA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4s0v HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi) 		5 / 12 PHE A1069
LEU A1086
PHE A1064
VAL A1093
ALA A1054
 None
 1.05A 1q23H-4s0vA:
undetectable
1q23I-4s0vA:
undetectable		 1q23H-4s0vA:
15.41
1q23I-4s0vA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TD2_A_PXLA288_1
(PYRIDOXAMINE KINASE)		 4s0v HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi) 		5 / 10 VAL A 140
ALA A  99
GLN A 134
VAL A 103
ASP A 100
 None
None
SUV  A2001 (-3.5A)
None
None
 1.34A 1td2A-4s0vA:
2.5		 1td2A-4s0vA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4s0v HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi) 		5 / 12 PHE A1121
TYR A1120
SER A1141
ALA A1160
GLY A1145
 None
 1.27A 2igtC-4s0vA:
undetectable		 2igtC-4s0vA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 4s0v HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi) 		5 / 10 ALA A1128
GLY A1155
ILE A1156
VAL A1143
LEU A1146
 None
 1.04A 3ogpA-4s0vA:
undetectable		 3ogpA-4s0vA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4s0v HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi) 		5 / 12 LEU A1058
LEU A1051
ILE A1170
PHE A1037
TYR A1120
 None
 1.40A 4a79A-4s0vA:
undetectable		 4a79A-4s0vA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4s0v HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi) 		5 / 12 LEU A1058
LEU A1051
ILE A1170
PHE A1037
TYR A1120
 None
 1.35A 4a79B-4s0vA:
undetectable		 4a79B-4s0vA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_A_RGZA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4s0v HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi) 		5 / 11 LEU A1058
LEU A1051
ILE A1170
PHE A1037
TYR A1120
 None
 1.40A 4a7aA-4s0vA:
undetectable		 4a7aA-4s0vA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 4s0v HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi) 		3 / 3 GLU A 212
ARG A 328
HIS A 224
 SUV  A2001 (-4.1A)
None
SUV  A2001 ( 4.8A)
 0.76A 4kf9A-4s0vA:
undetectable		 4kf9A-4s0vA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 4s0v HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi) 		3 / 3 PRO A 220
MET A 222
TYR A 219
 None
 0.96A 4qa2B-4s0vA:
undetectable		 4qa2B-4s0vA:
20.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZJ8_A_SUVA2001_1
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 4s0v HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi) 		11 / 12 ALA A 110
VAL A 114
GLN A 134
VAL A 138
GLN A 187
MET A 191
GLU A 212
PHE A 227
ASN A 324
HIS A 350
TYR A 354
 SUV  A2001 ( 4.2A)
SUV  A2001 (-4.6A)
SUV  A2001 (-3.5A)
None
SUV  A2001 (-3.6A)
SUV  A2001 ( 4.6A)
SUV  A2001 (-4.1A)
SUV  A2001 ( 4.5A)
SUV  A2001 (-3.0A)
SUV  A2001 ( 3.7A)
None
 0.52A 4zj8A-4s0vA:
46.2		 4zj8A-4s0vA:
83.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 4s0v HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi) 		6 / 6 TRP A 120
ILE A 130
PRO A 131
HIS A 224
ILE A 320
VAL A 353
 None
SUV  A2001 (-4.8A)
SUV  A2001 (-4.0A)
SUV  A2001 ( 4.8A)
SUV  A2001 (-4.1A)
SUV  A2001 ( 4.9A)
 0.38A 4zj8A-4s0vA:
46.2		 4zj8A-4s0vA:
83.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 4s0v HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi) 		4 / 5 GLU A 373
ALA A 377
GLU A 374
ASN A  82
 None
 1.48A 5dwkC-4s0vA:
2.4		 5dwkC-4s0vA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 4s0v HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi) 		4 / 4 VAL A  73
ALA A  68
ILE A 105
THR A 104
 None
 1.17A 5e4dB-4s0vA:
undetectable		 5e4dB-4s0vA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4s0v HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi) 		3 / 3 TYR A 364
TYR A 317
SER A 141
 None
 0.92A 5iktB-4s0vA:
undetectable		 5iktB-4s0vA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 4s0v HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi) 		5 / 10 PRO A1163
ALA A1140
GLY A1155
ILE A1150
ALA A1142
 None
 1.35A 5vyhA-4s0vA:
undetectable		 5vyhA-4s0vA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 4s0v HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi) 		4 / 8 ILE A1072
LEU A1108
LEU A1134
ALA A1131
 None
 0.87A 5y7pE-4s0vA:
undetectable		 5y7pE-4s0vA:
20.50