SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4s12'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 4s12 N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE
(Yersinia
enterocolitica) 		4 / 4 HIS A  92
LEU A 127
LEU A  98
LEU A 106
 None
 1.24A 1a4lD-4s12A:
undetectable		 1a4lD-4s12A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 4s12 N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE
(Yersinia
enterocolitica) 		4 / 6 ILE A  99
ALA A  70
THR A 144
ALA A 140
 None
SO4  A 301 ( 4.8A)
SO4  A 301 (-3.0A)
SO4  A 301 (-3.4A)
 0.91A 1w0gA-4s12A:
undetectable		 1w0gA-4s12A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4s12 N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE
(Yersinia
enterocolitica) 		5 / 12 LEU A 208
LEU A  65
GLY A 137
ALA A 163
ALA A 173
 None
 1.14A 2bm9D-4s12A:
2.6		 2bm9D-4s12A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		 4s12 N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE
(Yersinia
enterocolitica) 		5 / 12 LEU A 127
LEU A 129
LEU A 157
GLN A 156
LEU A  68
 None
 1.50A 2w8yB-4s12A:
undetectable		 2w8yB-4s12A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4s12 N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE
(Yersinia
enterocolitica) 		4 / 7 GLY A 211
ALA A 212
MET A 213
LEU A 216
 None
 0.57A 2wekB-4s12A:
3.6		 2wekB-4s12A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)		 4s12 N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE
(Yersinia
enterocolitica) 		4 / 4 PRO A 145
THR A 144
GLY A 191
THR A 190
 None
SO4  A 301 (-3.0A)
None
None
 1.08A 3ib1A-4s12A:
undetectable		 3ib1A-4s12A:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 4s12 N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE
(Yersinia
enterocolitica) 		4 / 7 GLY A 158
ALA A 131
ALA A  58
ASP A  61
 None
 0.88A 3ur0B-4s12A:
undetectable		 3ur0B-4s12A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 4s12 N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE
(Yersinia
enterocolitica) 		4 / 5 SER A 209
GLY A 211
THR A  87
VAL A 219
 None
 1.10A 4eohA-4s12A:
2.8		 4eohA-4s12A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 4s12 N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE
(Yersinia
enterocolitica) 		5 / 12 LEU A 129
ALA A 163
LEU A  65
ARG A  64
GLY A  62
 None
 1.17A 4l9qA-4s12A:
undetectable		 4l9qA-4s12A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 4s12 N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE
(Yersinia
enterocolitica) 		5 / 12 ALA A 140
SER A 197
GLY A 198
ALA A 109
GLY A  71
 SO4  A 301 (-3.4A)
None
None
None
None
 1.18A 4r29A-4s12A:
undetectable		 4r29A-4s12A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 4s12 N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE
(Yersinia
enterocolitica) 		5 / 12 ALA A 140
SER A 197
GLY A 198
ALA A 109
GLY A  71
 SO4  A 301 (-3.4A)
None
None
None
None
 1.17A 4r29B-4s12A:
undetectable		 4r29B-4s12A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 4s12 N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE
(Yersinia
enterocolitica) 		5 / 12 ALA A 140
SER A 197
GLY A 198
ALA A 109
GLY A  71
 SO4  A 301 (-3.4A)
None
None
None
None
 1.19A 4r29C-4s12A:
undetectable		 4r29C-4s12A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 4s12 N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE
(Yersinia
enterocolitica) 		4 / 6 ILE A 172
PRO A 171
ILE A   7
VAL A 183
 None
 1.01A 4zj8A-4s12A:
undetectable		 4zj8A-4s12A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4s12 N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE
(Yersinia
enterocolitica) 		5 / 12 TYR A 146
GLY A  74
LEU A 127
PHE A 153
THR A 132
 None
 1.12A 5eqbA-4s12A:
undetectable		 5eqbA-4s12A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4s12 N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE
(Yersinia
enterocolitica) 		4 / 5 TYR A 290
GLY A 289
GLY A  77
LEU A  59
 None
 0.87A 5jlcA-4s12A:
0.7		 5jlcA-4s12A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 4s12 N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE
(Yersinia
enterocolitica) 		5 / 9 LEU A 257
PRO A 266
VAL A 242
LEU A 291
ILE A 268
 None
 1.38A 6fdyU-4s12A:
undetectable		 6fdyU-4s12A:
19.87