SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4s15'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_A_CAMA502_0
(CYTOCHROME P450-CAM)		 4s15 NUCLEAR RECEPTOR
ROR-ALPHA
(Homo
sapiens) 		4 / 5 PHE A 303
TYR A 311
LEU A 322
VAL A 379
 None
 1.44A 1dz6A-4s15A:
undetectable		 1dz6A-4s15A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 4s15 NUCLEAR RECEPTOR
ROR-ALPHA
(Homo
sapiens) 		5 / 10 MET A 270
LEU A 273
LEU A 276
ALA A 277
LEU A 422
 None
 0.68A 1gwrA-4s15A:
22.6		 1gwrA-4s15A:
25.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 4s15 NUCLEAR RECEPTOR
ROR-ALPHA
(Homo
sapiens) 		8 / 11 CYH A 323
ILE A 327
ALA A 330
VAL A 364
ARG A 367
MET A 368
ARG A 370
VAL A 379
 4D8  A 601 ( 4.0A)
None
4D8  A 601 (-3.1A)
None
GOL  A 602 (-4.5A)
4D8  A 601 (-4.0A)
GOL  A 602 (-3.3A)
None
 0.33A 1n4hA-4s15A:
36.7		 1n4hA-4s15A:
59.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 4s15 NUCLEAR RECEPTOR
ROR-ALPHA
(Homo
sapiens) 		8 / 11 GLN A 289
CYH A 323
ILE A 327
ALA A 330
VAL A 364
MET A 368
ARG A 370
VAL A 379
 4D8  A 601 ( 2.7A)
4D8  A 601 ( 4.0A)
None
4D8  A 601 (-3.1A)
None
4D8  A 601 (-4.0A)
GOL  A 602 (-3.3A)
None
 0.74A 1n4hA-4s15A:
36.7		 1n4hA-4s15A:
59.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4s15 NUCLEAR RECEPTOR
ROR-ALPHA
(Homo
sapiens) 		5 / 12 GLN A 289
CYH A 323
ALA A 330
PHE A 391
HIS A 484
 4D8  A 601 ( 2.7A)
4D8  A 601 ( 4.0A)
4D8  A 601 (-3.1A)
4D8  A 601 ( 4.5A)
None
 0.89A 3b0wA-4s15A:
30.1		 3b0wA-4s15A:
53.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4s15 NUCLEAR RECEPTOR
ROR-ALPHA
(Homo
sapiens) 		9 / 12 GLN A 289
LEU A 295
CYH A 323
ALA A 330
MET A 368
ALA A 371
VAL A 379
PHE A 391
CYH A 396
 4D8  A 601 ( 2.7A)
None
4D8  A 601 ( 4.0A)
4D8  A 601 (-3.1A)
4D8  A 601 (-4.0A)
4D8  A 601 ( 4.0A)
None
4D8  A 601 ( 4.5A)
4D8  A 601 ( 4.7A)
 0.60A 3b0wA-4s15A:
30.1		 3b0wA-4s15A:
53.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4s15 NUCLEAR RECEPTOR
ROR-ALPHA
(Homo
sapiens) 		5 / 12 GLN A 289
CYH A 323
ALA A 330
LEU A 394
HIS A 484
 4D8  A 601 ( 2.7A)
4D8  A 601 ( 4.0A)
4D8  A 601 (-3.1A)
4D8  A 601 ( 4.5A)
None
 0.98A 3b0wB-4s15A:
30.7		 3b0wB-4s15A:
53.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4s15 NUCLEAR RECEPTOR
ROR-ALPHA
(Homo
sapiens) 		6 / 12 GLN A 289
LEU A 295
ALA A 330
ALA A 371
VAL A 379
LEU A 394
 4D8  A 601 ( 2.7A)
None
4D8  A 601 (-3.1A)
4D8  A 601 ( 4.0A)
None
4D8  A 601 ( 4.5A)
 1.36A 3b0wB-4s15A:
30.7		 3b0wB-4s15A:
53.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4s15 NUCLEAR RECEPTOR
ROR-ALPHA
(Homo
sapiens) 		9 / 12 GLN A 289
LEU A 295
CYH A 323
ALA A 330
MET A 368
ALA A 371
VAL A 379
PHE A 391
LEU A 394
 4D8  A 601 ( 2.7A)
None
4D8  A 601 ( 4.0A)
4D8  A 601 (-3.1A)
4D8  A 601 (-4.0A)
4D8  A 601 ( 4.0A)
None
4D8  A 601 ( 4.5A)
4D8  A 601 ( 4.5A)
 0.46A 3b0wB-4s15A:
30.7		 3b0wB-4s15A:
53.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 4s15 NUCLEAR RECEPTOR
ROR-ALPHA
(Homo
sapiens) 		5 / 12 MET A 270
LEU A 273
LEU A 276
ALA A 277
LEU A 422
 None
 0.63A 3olsA-4s15A:
22.9		 3olsA-4s15A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 4s15 NUCLEAR RECEPTOR
ROR-ALPHA
(Homo
sapiens) 		5 / 12 VAL A 379
ASN A 377
ILE A 327
PHE A 399
ILE A 400
 None
 1.27A 3q5pA-4s15A:
undetectable		 3q5pA-4s15A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5R_A_KANA2002_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 4s15 NUCLEAR RECEPTOR
ROR-ALPHA
(Homo
sapiens) 		5 / 11 VAL A 379
ASN A 377
ILE A 327
PHE A 399
ILE A 400
 None
 1.34A 3q5rA-4s15A:
undetectable		 3q5rA-4s15A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 4s15 NUCLEAR RECEPTOR
ROR-ALPHA
(Homo
sapiens) 		5 / 12 MET A 270
LEU A 273
LEU A 276
ALA A 277
LEU A 422
 None
 0.60A 3q95B-4s15A:
22.3		 3q95B-4s15A:
24.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4s15 NUCLEAR RECEPTOR
ROR-ALPHA
(Homo
sapiens) 		4 / 8 GLU A 443
GLN A 446
VAL A 474
ARG A 478
 None
 0.92A 4lnwA-4s15A:
26.7		 4lnwA-4s15A:
32.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4s15 NUCLEAR RECEPTOR
ROR-ALPHA
(Homo
sapiens) 		4 / 6 GLU A 443
GLN A 446
VAL A 474
ARG A 478
 None
 1.01A 4lnxA-4s15A:
26.8		 4lnxA-4s15A:
32.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_A_ESTA2000_1
(ESTROGEN RECEPTOR)		 4s15 NUCLEAR RECEPTOR
ROR-ALPHA
(Homo
sapiens) 		5 / 12 MET A 270
LEU A 273
LEU A 276
ALA A 277
LEU A 422
 None
 0.65A 4pxmA-4s15A:
22.0		 4pxmA-4s15A:
24.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4s15 NUCLEAR RECEPTOR
ROR-ALPHA
(Homo
sapiens) 		7 / 9 LEU A 295
ALA A 330
VAL A 364
ARG A 367
MET A 368
ARG A 370
ALA A 371
 None
4D8  A 601 (-3.1A)
None
GOL  A 602 (-4.5A)
4D8  A 601 (-4.0A)
GOL  A 602 (-3.3A)
4D8  A 601 ( 4.0A)
 0.62A 5g44A-4s15A:
34.9		 5g44A-4s15A:
50.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4s15 NUCLEAR RECEPTOR
ROR-ALPHA
(Homo
sapiens) 		5 / 9 LEU A 356
ILE A 341
GLU A 346
PHE A 344
GLU A 336
 None
 1.39A 5igzA-4s15A:
undetectable		 5igzA-4s15A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4s15 NUCLEAR RECEPTOR
ROR-ALPHA
(Homo
sapiens) 		4 / 6 GLN A 332
PHE A 511
LEU A 361
PHE A 365
 None
 1.12A 5zcpC-4s15A:
undetectable
5zcpJ-4s15A:
undetectable		 5zcpC-4s15A:
20.98
5zcpJ-4s15A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 4s15 NUCLEAR RECEPTOR
ROR-ALPHA
(Homo
sapiens) 		4 / 6 PHE A 399
LEU A 477
LEU A 480
HIS A 484
 None
 0.68A 6e43A-4s15A:
undetectable		 6e43A-4s15A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 4s15 NUCLEAR RECEPTOR
ROR-ALPHA
(Homo
sapiens) 		4 / 6 PHE A 399
LEU A 477
LEU A 480
HIS A 484
 None
 0.72A 6e43B-4s15A:
undetectable		 6e43B-4s15A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 4s15 NUCLEAR RECEPTOR
ROR-ALPHA
(Homo
sapiens) 		4 / 6 PHE A 399
LEU A 477
LEU A 480
HIS A 484
 None
 0.68A 6e43C-4s15A:
undetectable		 6e43C-4s15A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 4s15 NUCLEAR RECEPTOR
ROR-ALPHA
(Homo
sapiens) 		4 / 6 PHE A 399
LEU A 477
LEU A 480
HIS A 484
 None
 0.75A 6e43D-4s15A:
1.0		 6e43D-4s15A:
21.89