SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4s17'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		4 / 6 SER A 158
PHE A 138
GLU A 160
GLY A 223
 None
 1.15A 1kqbA-4s17A:
undetectable
1kqbB-4s17A:
undetectable		 1kqbA-4s17A:
19.92
1kqbB-4s17A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		4 / 8 HIS A 238
ASP A 241
PHE A 378
ASP A  75
 None
 1.10A 1p7lC-4s17A:
undetectable		 1p7lC-4s17A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		4 / 8 HIS A 238
ASP A 241
PHE A 378
ASP A  75
 None
 1.09A 1p7lD-4s17A:
undetectable		 1p7lD-4s17A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		4 / 8 HIS A 238
ASP A 241
PHE A 378
ASP A  75
 None
 1.10A 1rg9A-4s17A:
undetectable		 1rg9A-4s17A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		4 / 8 HIS A 238
ASP A 241
PHE A 378
ASP A  75
 None
 1.10A 1rg9B-4s17A:
undetectable		 1rg9B-4s17A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		4 / 8 HIS A 238
ASP A 241
PHE A 378
ASP A  75
 None
 1.10A 1rg9C-4s17A:
undetectable		 1rg9C-4s17A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		4 / 8 HIS A 238
ASP A 241
PHE A 378
ASP A  75
 None
 1.09A 1rg9D-4s17A:
undetectable		 1rg9D-4s17A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA471_1
(CYTOCHROME P450 51)		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		4 / 8 PHE A  80
ARG A  25
LEU A 256
MET A 203
 None
 1.14A 1x8vA-4s17A:
undetectable		 1x8vA-4s17A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OBV_A_SAMA501_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1)		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		4 / 8 HIS A 238
ASP A 241
PHE A 378
ASP A  75
 None
 1.04A 2obvA-4s17A:
undetectable		 2obvA-4s17A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		4 / 8 HIS A 238
ASP A 241
PHE A 378
ASP A  75
 None
 1.10A 2p02A-4s17A:
undetectable		 2p02A-4s17A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		4 / 6 PHE A 290
ILE A 366
GLY A 309
GLY A 308
 None
 0.82A 2qx6A-4s17A:
undetectable
2qx6B-4s17A:
undetectable		 2qx6A-4s17A:
19.32
2qx6B-4s17A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		5 / 12 PHE A 131
ALA A 380
ALA A 126
THR A 123
LEU A 389
 None
 1.27A 2x2nB-4s17A:
undetectable		 2x2nB-4s17A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_0
(N,N-DIMETHYLTRANSFER
ASE)		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		5 / 12 ALA A 116
GLY A 114
LEU A 120
PHE A 378
SER A 382
 None
 0.93A 3bxoB-4s17A:
undetectable		 3bxoB-4s17A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAU_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		5 / 12 ALA A 116
LEU A 379
ALA A 380
ILE A 449
LEU A 431
 None
 0.90A 3dauA-4s17A:
undetectable		 3dauA-4s17A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		4 / 5 PRO A 265
THR A  27
VAL A  32
GLY A  31
 None
 1.18A 3elzA-4s17A:
undetectable		 3elzA-4s17A:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		5 / 12 LEU A   4
VAL A  76
ILE A  14
LEU A  90
PHE A  43
 None
 1.04A 3fl9B-4s17A:
undetectable		 3fl9B-4s17A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		5 / 11 LEU A   4
VAL A  76
ILE A  14
LEU A  90
PHE A  43
 None
 1.10A 3fl9C-4s17A:
undetectable		 3fl9C-4s17A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		5 / 12 LEU A   4
VAL A  76
ILE A  14
LEU A  90
PHE A  43
 None
 1.10A 3fl9G-4s17A:
undetectable		 3fl9G-4s17A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		5 / 12 ALA A 222
GLU A 228
LEU A 243
ASP A 372
GLY A 275
 None
MG  A 501 (-2.4A)
None
None
None
 1.14A 3k2hA-4s17A:
undetectable		 3k2hA-4s17A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		5 / 12 ALA A 222
GLU A 228
LEU A 243
ASP A 372
GLY A 275
 None
MG  A 501 (-2.4A)
None
None
None
 1.12A 3k2hB-4s17A:
undetectable		 3k2hB-4s17A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		5 / 12 ASP A  75
ARG A 110
THR A  78
ALA A 383
ALA A 116
 None
 1.26A 3ua1A-4s17A:
undetectable		 3ua1A-4s17A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_1
(WBDD)		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		4 / 6 GLN A  33
ASP A 241
GLN A 237
GLU A   5
 None
 1.10A 4azvA-4s17A:
undetectable		 4azvA-4s17A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		4 / 8 ASP A   9
VAL A  92
PHE A  48
LEU A  44
 None
 1.11A 4f8hB-4s17A:
undetectable
4f8hC-4s17A:
undetectable		 4f8hB-4s17A:
23.05
4f8hC-4s17A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		4 / 8 VAL A  92
PHE A  48
LEU A  44
ASP A   9
 None
 1.10A 4f8hA-4s17A:
undetectable
4f8hE-4s17A:
undetectable		 4f8hA-4s17A:
23.05
4f8hE-4s17A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		4 / 7 ILE A 268
PRO A 267
GLY A 275
ALA A 222
 None
 0.98A 4g0uB-4s17A:
undetectable		 4g0uB-4s17A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		5 / 12 PHE A 140
GLY A 273
GLY A 275
ALA A 222
ILE A 268
 None
 1.07A 4krhA-4s17A:
undetectable		 4krhA-4s17A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		5 / 12 PHE A 140
GLY A 273
GLY A 275
ALA A 222
ILE A 268
 None
 1.04A 4krhB-4s17A:
undetectable		 4krhB-4s17A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		4 / 8 HIS A 238
ASP A 241
PHE A 378
ASP A  75
 None
 1.09A 4kttA-4s17A:
undetectable		 4kttA-4s17A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		4 / 8 HIS A 238
ASP A 241
PHE A 378
ASP A  75
 None
 1.09A 4kttC-4s17A:
undetectable		 4kttC-4s17A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_1
(MDR769 HIV-1
PROTEASE)		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		5 / 11 GLY A 388
ALA A 387
THR A 321
PRO A 371
VAL A 317
 None
 1.14A 4l1aA-4s17A:
undetectable		 4l1aA-4s17A:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		4 / 8 HIS A 238
ASP A 241
PHE A 378
ASP A  75
 None
 1.09A 4ndnA-4s17A:
undetectable		 4ndnA-4s17A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		4 / 7 HIS A 238
ASP A 241
PHE A 378
ASP A  75
 None
 1.07A 4ndnC-4s17A:
undetectable		 4ndnC-4s17A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		4 / 7 HIS A 238
ASP A 241
PHE A 378
ASP A  75
 None
 1.03A 4odjA-4s17A:
undetectable		 4odjA-4s17A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		5 / 12 ALA A 116
LEU A 379
ALA A 380
ILE A 449
LEU A 431
 None
 0.93A 4psyA-4s17A:
undetectable		 4psyA-4s17A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		5 / 12 ALA A 383
PHE A 368
ILE A 366
LEU A 389
ILE A 307
 None
 1.08A 4uw0A-4s17A:
undetectable		 4uw0A-4s17A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_ADNA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		4 / 8 HIS A 238
ASP A 241
PHE A 378
ASP A  75
 None
 1.08A 5a1iA-4s17A:
2.6		 5a1iA-4s17A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		4 / 7 HIS A 238
ASP A 241
PHE A 378
ASP A  75
 None
 1.08A 5a1iA-4s17A:
undetectable		 5a1iA-4s17A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		5 / 12 LEU A 331
GLY A 273
GLU A 136
GLY A 275
ARG A 369
 None
None
MG  A 501 (-3.2A)
None
None
 1.22A 5o4yD-4s17A:
undetectable
5o4yE-4s17A:
undetectable		 5o4yD-4s17A:
2.70
5o4yE-4s17A:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		4 / 8 HIS A 238
ASP A 241
PHE A 378
ASP A  75
 None
 1.01A 5t8sB-4s17A:
undetectable		 5t8sB-4s17A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		5 / 12 ALA A 161
PRO A 162
GLY A 223
ILE A 167
ASP A 172
 None
 1.27A 5wwsB-4s17A:
undetectable		 5wwsB-4s17A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		4 / 5 GLN A 111
VAL A 112
PRO A 104
THR A 439
 None
 1.05A 6cduA-4s17A:
undetectable
6cduB-4s17A:
undetectable		 6cduA-4s17A:
21.95
6cduB-4s17A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		4 / 6 GLN A 111
VAL A 112
PRO A 104
THR A 439
 None
 1.03A 6cduB-4s17A:
undetectable
6cduC-4s17A:
undetectable		 6cduB-4s17A:
21.95
6cduC-4s17A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_I_EY4I500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		4 / 5 GLN A 111
VAL A 112
PRO A 104
THR A 439
 None
 0.99A 6cduI-4s17A:
undetectable
6cduJ-4s17A:
undetectable		 6cduI-4s17A:
21.95
6cduJ-4s17A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		4 / 8 HIS A 238
ASP A 241
PHE A 378
ASP A  75
 None
 1.09A 6fbnB-4s17A:
undetectable		 6fbnB-4s17A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBO_A_ADNA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		4 / 8 HIS A 238
ASP A 241
PHE A 378
ASP A  75
 None
 1.06A 6fboA-4s17A:
undetectable		 6fboA-4s17A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		4 / 8 HIS A 238
ASP A 241
PHE A 378
ASP A  75
 None
 1.11A 6fcbA-4s17A:
undetectable		 6fcbA-4s17A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCD_A_ADNA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		4 / 8 HIS A 238
ASP A 241
PHE A 378
ASP A  75
 None
 1.07A 6fcdA-4s17A:
undetectable		 6fcdA-4s17A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		4 / 7 HIS A 238
ASP A 241
PHE A 378
ASP A  75
 None
 1.08A 6g6rA-4s17A:
undetectable		 6g6rA-4s17A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		4 / 6 PRO A 399
ILE A 352
GLY A 308
TYR A 343
 None
 1.13A 6gqiA-4s17A:
undetectable		 6gqiA-4s17A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		4 / 8 ILE A 455
TRP A 452
ARG A 107
ASN A 376
 None
 1.25A 6hisB-4s17A:
undetectable
6hisC-4s17A:
undetectable		 6hisB-4s17A:
9.89
6hisC-4s17A:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		4 / 8 ILE A 455
TRP A 452
ARG A 107
ASN A 376
 None
 1.25A 6hisC-4s17A:
undetectable
6hisD-4s17A:
undetectable		 6hisC-4s17A:
9.89
6hisD-4s17A:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4s17 GLUTAMINE SYNTHETASE
(Bifidobacterium
adolescentis) 		4 / 8 ASN A 376
ILE A 455
TRP A 452
ARG A 107
 None
 1.26A 6hisA-4s17A:
undetectable
6hisE-4s17A:
undetectable		 6hisA-4s17A:
9.89
6hisE-4s17A:
9.89