SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4s1b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 4s1b LMO1466 PROTEIN
(Listeria
monocytogenes) 		4 / 8 ASP A 544
HIS A 543
HIS A 604
HIS A 514
 FE  A 802 (-2.7A)
FE  A 802 (-3.4A)
FE  A 801 (-3.5A)
FE  A 802 ( 3.4A)
 0.66A 1ei6D-4s1bA:
undetectable		 1ei6D-4s1bA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 4s1b LMO1466 PROTEIN
(Listeria
monocytogenes) 		5 / 6 HIS A 543
HIS A 514
HIS A 580
HIS A 604
ASP A 648
 FE  A 802 (-3.4A)
FE  A 802 ( 3.4A)
FE  A 801 ( 3.5A)
FE  A 801 (-3.5A)
FE  A 802 ( 2.6A)
 1.17A 1fweC-4s1bA:
undetectable		 1fweC-4s1bA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4s1b LMO1466 PROTEIN
(Listeria
monocytogenes) 		5 / 12 GLN A 558
ASP A 648
VAL A 518
ASP A 544
HIS A 605
 2BA  A 803 ( 4.2A)
FE  A 802 ( 2.6A)
None
FE  A 802 (-2.7A)
FE  A 801 ( 3.5A)
 1.24A 2x2iB-4s1bA:
undetectable		 2x2iB-4s1bA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4s1b LMO1466 PROTEIN
(Listeria
monocytogenes) 		5 / 12 GLN A 558
ASP A 648
VAL A 518
ASP A 544
HIS A 605
 2BA  A 803 ( 4.2A)
FE  A 802 ( 2.6A)
None
FE  A 802 (-2.7A)
FE  A 801 ( 3.5A)
 1.26A 2x2iD-4s1bA:
undetectable		 2x2iD-4s1bA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 4s1b LMO1466 PROTEIN
(Listeria
monocytogenes) 		4 / 8 HIS A 604
ASP A 648
HIS A 580
ASP A 544
 FE  A 801 (-3.5A)
FE  A 802 ( 2.6A)
FE  A 801 ( 3.5A)
FE  A 802 (-2.7A)
 1.04A 2xadA-4s1bA:
undetectable		 2xadA-4s1bA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 4s1b LMO1466 PROTEIN
(Listeria
monocytogenes) 		4 / 8 HIS A 604
ASP A 648
HIS A 580
ASP A 544
 FE  A 801 (-3.5A)
FE  A 802 ( 2.6A)
FE  A 801 ( 3.5A)
FE  A 802 (-2.7A)
 1.06A 2xadB-4s1bA:
undetectable		 2xadB-4s1bA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 4s1b LMO1466 PROTEIN
(Listeria
monocytogenes) 		4 / 8 HIS A 604
ASP A 648
HIS A 580
ASP A 544
 FE  A 801 (-3.5A)
FE  A 802 ( 2.6A)
FE  A 801 ( 3.5A)
FE  A 802 (-2.7A)
 1.05A 2xadC-4s1bA:
undetectable		 2xadC-4s1bA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 4s1b LMO1466 PROTEIN
(Listeria
monocytogenes) 		4 / 8 HIS A 604
ASP A 648
HIS A 580
ASP A 544
 FE  A 801 (-3.5A)
FE  A 802 ( 2.6A)
FE  A 801 ( 3.5A)
FE  A 802 (-2.7A)
 1.05A 2xadD-4s1bA:
undetectable		 2xadD-4s1bA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)		 4s1b LMO1466 PROTEIN
(Listeria
monocytogenes) 		5 / 12 HIS A 604
ASP A 648
ASP A 544
SER A 573
ILE A 577
 FE  A 801 (-3.5A)
FE  A 802 ( 2.6A)
FE  A 802 (-2.7A)
None
2BA  A 803 (-3.9A)
 1.32A 3b7pC-4s1bA:
undetectable		 3b7pC-4s1bA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4s1b LMO1466 PROTEIN
(Listeria
monocytogenes) 		5 / 10 ILE A 545
GLY A 584
ALA A 585
HIS A 580
HIS A 604
 None
None
None
FE  A 801 ( 3.5A)
FE  A 801 (-3.5A)
 1.47A 3boyA-4s1bA:
1.2
3boyC-4s1bA:
undetectable		 3boyA-4s1bA:
20.18
3boyC-4s1bA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4s1b LMO1466 PROTEIN
(Listeria
monocytogenes) 		5 / 10 HIS A 580
HIS A 604
ILE A 545
GLY A 584
ALA A 585
 FE  A 801 ( 3.5A)
FE  A 801 (-3.5A)
None
None
None
 1.47A 3boyA-4s1bA:
1.2
3boyB-4s1bA:
undetectable		 3boyA-4s1bA:
20.18
3boyB-4s1bA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 4s1b LMO1466 PROTEIN
(Listeria
monocytogenes) 		5 / 10 HIS A 605
HIS A 604
ASP A 648
HIS A 580
HIS A 514
 FE  A 801 ( 3.5A)
FE  A 801 (-3.5A)
FE  A 802 ( 2.6A)
FE  A 801 ( 3.5A)
FE  A 802 ( 3.4A)
 1.12A 4c1dB-4s1bA:
undetectable		 4c1dB-4s1bA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 4s1b LMO1466 PROTEIN
(Listeria
monocytogenes) 		5 / 9 HIS A 605
HIS A 604
ASP A 648
HIS A 580
HIS A 514
 FE  A 801 ( 3.5A)
FE  A 801 (-3.5A)
FE  A 802 ( 2.6A)
FE  A 801 ( 3.5A)
FE  A 802 ( 3.4A)
 1.12A 4c1hA-4s1bA:
undetectable		 4c1hA-4s1bA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 4s1b LMO1466 PROTEIN
(Listeria
monocytogenes) 		5 / 6 HIS A 543
HIS A 514
HIS A 580
HIS A 604
ASP A 648
 FE  A 802 (-3.4A)
FE  A 802 ( 3.4A)
FE  A 801 ( 3.5A)
FE  A 801 (-3.5A)
FE  A 802 ( 2.6A)
 1.07A 4ubpC-4s1bA:
undetectable		 4ubpC-4s1bA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4s1b LMO1466 PROTEIN
(Listeria
monocytogenes) 		4 / 5 THR A 581
GLY A 546
GLU A 556
HIS A 514
 None
None
2BA  A 803 (-2.9A)
FE  A 802 ( 3.4A)
 1.17A 5c0oH-4s1bA:
undetectable		 5c0oH-4s1bA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)		 4s1b LMO1466 PROTEIN
(Listeria
monocytogenes) 		4 / 5 GLN A 603
HIS A 605
ILE A 641
ILE A 644
 None
FE  A 801 ( 3.5A)
None
None
 1.22A 5dnvA-4s1bA:
undetectable		 5dnvA-4s1bA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 4s1b LMO1466 PROTEIN
(Listeria
monocytogenes) 		3 / 3 THR A 661
HIS A 708
ASN A 704
 None
 0.80A 5n4tA-4s1bA:
undetectable		 5n4tA-4s1bA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4s1b LMO1466 PROTEIN
(Listeria
monocytogenes) 		4 / 8 ASP A 544
HIS A 604
HIS A 580
HIS A 514
 FE  A 802 (-2.7A)
FE  A 801 (-3.5A)
FE  A 801 ( 3.5A)
FE  A 802 ( 3.4A)
 1.01A 5nekB-4s1bA:
undetectable		 5nekB-4s1bA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 4s1b LMO1466 PROTEIN
(Listeria
monocytogenes) 		3 / 3 HIS A 605
HIS A 604
HIS A 580
 FE  A 801 ( 3.5A)
FE  A 801 (-3.5A)
FE  A 801 ( 3.5A)
 0.46A 5zrdA-4s1bA:
undetectable		 5zrdA-4s1bA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4s1b LMO1466 PROTEIN
(Listeria
monocytogenes) 		4 / 8 ILE A 644
VAL A 518
THR A 511
TYR A 512
 None
 0.66A 6cduG-4s1bA:
undetectable
6cduH-4s1bA:
undetectable		 6cduG-4s1bA:
21.88
6cduH-4s1bA:
21.88