SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4s1i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 4s1i PYRIDOXAL KINASE
(Entamoeba
histolytica) 		3 / 3 PHE B  84
LEU B 114
SER B 129
 None
 0.86A 1e7aA-4s1iB:
2.0		 1e7aA-4s1iB:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 4s1i PYRIDOXAL KINASE
(Entamoeba
histolytica) 		4 / 8 SER B  33
THR B 221
ASP B 111
LEU B  26
 None
None
MG  B 301 ( 4.1A)
None
 1.11A 1lhvA-4s1iB:
undetectable		 1lhvA-4s1iB:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TD2_A_PXLA288_1
(PYRIDOXAMINE KINASE)		 4s1i PYRIDOXAL KINASE
(Entamoeba
histolytica) 		6 / 10 SER B  10
VAL B  12
HIS B  44
THR B  45
TYR B  83
ASP B 218
 PLP  B 302 (-2.4A)
None
PLP  B 302 (-3.8A)
PLP  B 302 (-3.2A)
PLP  B 302 (-3.8A)
PLP  B 302 (-3.5A)
 0.32A 1td2A-4s1iB:
32.9		 1td2A-4s1iB:
27.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TD2_B_PXLB289_1
(PYRIDOXAMINE KINASE)		 4s1i PYRIDOXAL KINASE
(Entamoeba
histolytica) 		5 / 9 SER B  10
HIS B  44
THR B  45
TYR B  83
ASP B 218
 PLP  B 302 (-2.4A)
PLP  B 302 (-3.8A)
PLP  B 302 (-3.2A)
PLP  B 302 (-3.8A)
PLP  B 302 (-3.5A)
 0.31A 1td2B-4s1iB:
33.0		 1td2B-4s1iB:
27.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 4s1i PYRIDOXAL KINASE
(Entamoeba
histolytica) 		6 / 8 SER B  10
VAL B  12
VAL B  17
LEU B  41
TYR B  83
ASP B 218
 PLP  B 302 (-2.4A)
None
PLP  B 302 (-4.4A)
PLP  B 302 (-4.9A)
PLP  B 302 (-3.8A)
PLP  B 302 (-3.5A)
 0.54A 2ddwA-4s1iB:
33.1		 2ddwA-4s1iB:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 4s1i PYRIDOXAL KINASE
(Entamoeba
histolytica) 		4 / 7 SER B  10
LEU B  41
GLY B 215
ASP B 218
 PLP  B 302 (-2.4A)
PLP  B 302 (-4.9A)
None
PLP  B 302 (-3.5A)
 0.60A 2ddwB-4s1iB:
31.1		 2ddwB-4s1iB:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 4s1i PYRIDOXAL KINASE
(Entamoeba
histolytica) 		5 / 12 ILE B   8
THR B  38
ASP B 111
ILE B  25
LEU B  26
 None
None
MG  B 301 ( 4.1A)
None
None
 1.12A 2jn3A-4s1iB:
undetectable		 2jn3A-4s1iB:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4s1i PYRIDOXAL KINASE
(Entamoeba
histolytica) 		3 / 3 TYR B 121
GLU B 146
THR B 221
 PLP  B 302 ( 4.0A)
MG  B 301 ( 3.9A)
None
 1.02A 2y7hB-4s1iB:
1.4		 2y7hB-4s1iB:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4s1i PYRIDOXAL KINASE
(Entamoeba
histolytica) 		3 / 3 TYR B  47
GLU B 257
ASN B 259
 None
 0.89A 2y7hC-4s1iB:
undetectable		 2y7hC-4s1iB:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 4s1i PYRIDOXAL KINASE
(Entamoeba
histolytica) 		5 / 9 THR B  38
VAL B 126
SER B 124
ILE B   8
GLY B  82
 None
 1.19A 3cv9A-4s1iB:
undetectable		 3cv9A-4s1iB:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4s1i PYRIDOXAL KINASE
(Entamoeba
histolytica) 		4 / 6 GLY B  18
TYR B  11
GLY B  22
MET B  23
 PLP  B 302 ( 4.4A)
None
None
None
 1.05A 3e9rA-4s1iB:
2.4		 3e9rA-4s1iB:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4s1i PYRIDOXAL KINASE
(Entamoeba
histolytica) 		4 / 6 GLY B  18
TYR B  11
GLY B  22
MET B  23
 PLP  B 302 ( 4.4A)
None
None
None
 1.01A 3e9rC-4s1iB:
undetectable		 3e9rC-4s1iB:
22.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MBH_A_PXLA400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 4s1i PYRIDOXAL KINASE
(Entamoeba
histolytica) 		7 / 11 VAL B  17
LEU B  41
HIS B  44
THR B  45
TYR B  83
TYR B 121
ASP B 218
 PLP  B 302 (-4.4A)
PLP  B 302 (-4.9A)
PLP  B 302 (-3.8A)
PLP  B 302 (-3.2A)
PLP  B 302 (-3.8A)
PLP  B 302 ( 4.0A)
PLP  B 302 (-3.5A)
 0.64A 3mbhA-4s1iB:
33.4		 3mbhA-4s1iB:
30.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MBH_B_PXLB400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 4s1i PYRIDOXAL KINASE
(Entamoeba
histolytica) 		7 / 12 VAL B  17
LEU B  41
HIS B  44
THR B  45
TYR B  83
TYR B 121
ASP B 218
 PLP  B 302 (-4.4A)
PLP  B 302 (-4.9A)
PLP  B 302 (-3.8A)
PLP  B 302 (-3.2A)
PLP  B 302 (-3.8A)
PLP  B 302 ( 4.0A)
PLP  B 302 (-3.5A)
 0.61A 3mbhB-4s1iB:
33.4		 3mbhB-4s1iB:
30.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MBH_C_PXLC400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 4s1i PYRIDOXAL KINASE
(Entamoeba
histolytica) 		7 / 12 VAL B  17
LEU B  41
HIS B  44
THR B  45
TYR B  83
TYR B 121
ASP B 218
 PLP  B 302 (-4.4A)
PLP  B 302 (-4.9A)
PLP  B 302 (-3.8A)
PLP  B 302 (-3.2A)
PLP  B 302 (-3.8A)
PLP  B 302 ( 4.0A)
PLP  B 302 (-3.5A)
 0.61A 3mbhC-4s1iB:
33.8		 3mbhC-4s1iB:
30.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MBH_D_PXLD400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 4s1i PYRIDOXAL KINASE
(Entamoeba
histolytica) 		7 / 12 VAL B  17
LEU B  41
HIS B  44
THR B  45
TYR B  83
TYR B 121
ASP B 218
 PLP  B 302 (-4.4A)
PLP  B 302 (-4.9A)
PLP  B 302 (-3.8A)
PLP  B 302 (-3.2A)
PLP  B 302 (-3.8A)
PLP  B 302 ( 4.0A)
PLP  B 302 (-3.5A)
 0.62A 3mbhD-4s1iB:
33.8		 3mbhD-4s1iB:
30.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MBH_E_PXLE400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 4s1i PYRIDOXAL KINASE
(Entamoeba
histolytica) 		7 / 12 VAL B  17
LEU B  41
HIS B  44
THR B  45
TYR B  83
TYR B 121
ASP B 218
 PLP  B 302 (-4.4A)
PLP  B 302 (-4.9A)
PLP  B 302 (-3.8A)
PLP  B 302 (-3.2A)
PLP  B 302 (-3.8A)
PLP  B 302 ( 4.0A)
PLP  B 302 (-3.5A)
 0.62A 3mbhE-4s1iB:
33.5		 3mbhE-4s1iB:
30.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MBH_F_PXLF400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 4s1i PYRIDOXAL KINASE
(Entamoeba
histolytica) 		7 / 11 VAL B  17
LEU B  41
HIS B  44
THR B  45
TYR B  83
TYR B 121
ASP B 218
 PLP  B 302 (-4.4A)
PLP  B 302 (-4.9A)
PLP  B 302 (-3.8A)
PLP  B 302 (-3.2A)
PLP  B 302 (-3.8A)
PLP  B 302 ( 4.0A)
PLP  B 302 (-3.5A)
 0.62A 3mbhF-4s1iB:
33.3		 3mbhF-4s1iB:
30.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4s1i PYRIDOXAL KINASE
(Entamoeba
histolytica) 		5 / 12 LEU B 177
ILE B 276
ILE B 204
ILE B 223
ALA B 237
 None
 1.20A 3uj7A-4s1iB:
undetectable		 3uj7A-4s1iB:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 4s1i PYRIDOXAL KINASE
(Entamoeba
histolytica) 		4 / 5 SER B  10
GLY B  18
THR B  45
ASP B 218
 PLP  B 302 (-2.4A)
PLP  B 302 ( 4.4A)
PLP  B 302 (-3.2A)
PLP  B 302 (-3.5A)
 0.72A 4eohA-4s1iB:
34.2		 4eohA-4s1iB:
29.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_D_FK5D201_1
(FK506-BINDING
PROTEIN 1)		 4s1i PYRIDOXAL KINASE
(Entamoeba
histolytica) 		5 / 11 PHE B 202
VAL B 238
ILE B 242
ILE B 181
ILE B 187
 None
 1.22A 5hw8D-4s1iB:
undetectable		 5hw8D-4s1iB:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4s1i PYRIDOXAL KINASE
(Entamoeba
histolytica) 		5 / 12 GLY B 215
LEU B 109
GLY B  82
SER B  10
ILE B 113
 None
None
None
PLP  B 302 (-2.4A)
PLP  B 302 ( 4.7A)
 1.13A 5vooA-4s1iB:
2.4		 5vooA-4s1iB:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4s1i PYRIDOXAL KINASE
(Entamoeba
histolytica) 		5 / 12 GLY B 215
LEU B 109
GLY B  82
SER B  10
ILE B 113
 None
None
None
PLP  B 302 (-2.4A)
PLP  B 302 ( 4.7A)
 1.13A 5vooB-4s1iB:
3.0		 5vooB-4s1iB:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4s1i PYRIDOXAL KINASE
(Entamoeba
histolytica) 		5 / 12 GLY B 215
LEU B 109
GLY B  82
SER B  10
ILE B 113
 None
None
None
PLP  B 302 (-2.4A)
PLP  B 302 ( 4.7A)
 1.14A 5vooC-4s1iB:
3.0		 5vooC-4s1iB:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4s1i PYRIDOXAL KINASE
(Entamoeba
histolytica) 		5 / 12 GLY B 215
LEU B 109
GLY B  82
SER B  10
ILE B 113
 None
None
None
PLP  B 302 (-2.4A)
PLP  B 302 ( 4.7A)
 1.09A 5vooD-4s1iB:
2.8		 5vooD-4s1iB:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4s1i PYRIDOXAL KINASE
(Entamoeba
histolytica) 		5 / 12 GLY B 215
LEU B 109
GLY B  82
SER B  10
ILE B 113
 None
None
None
PLP  B 302 (-2.4A)
PLP  B 302 ( 4.7A)
 1.18A 5vooE-4s1iB:
2.7		 5vooE-4s1iB:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4s1i PYRIDOXAL KINASE
(Entamoeba
histolytica) 		5 / 12 GLY B 215
LEU B 109
GLY B  82
SER B  10
ILE B 113
 None
None
None
PLP  B 302 (-2.4A)
PLP  B 302 ( 4.7A)
 1.15A 5vooF-4s1iB:
2.7		 5vooF-4s1iB:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4s1i PYRIDOXAL KINASE
(Entamoeba
histolytica) 		5 / 12 GLY B 215
LEU B 109
GLY B  82
SER B  10
ILE B 113
 None
None
None
PLP  B 302 (-2.4A)
PLP  B 302 ( 4.7A)
 1.16A 5vopB-4s1iB:
2.2		 5vopB-4s1iB:
19.68