SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4s1j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		 4s1j PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Leishmania
donovani) 		5 / 11 ASP A  73
GLY A  88
GLY A  87
PHE A  76
PHE A  31
 None
 0.75A 1w76A-4s1jA:
undetectable		 1w76A-4s1jA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 4s1j PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Leishmania
donovani) 		5 / 9 LEU A  40
VAL A 179
THR A 167
ILE A  85
VAL A  79
 None
 1.39A 2l8mA-4s1jA:
undetectable		 2l8mA-4s1jA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 4s1j PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Leishmania
donovani) 		4 / 7 GLY A  88
GLN A 133
SER A  74
HIS A  77
 None
 1.15A 4ws0A-4s1jA:
undetectable		 4ws0A-4s1jA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_2
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 4s1j PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Leishmania
donovani) 		4 / 5 PHE A  48
HIS A 115
LEU A 120
PRO A  23
 None
 1.34A 5csyB-4s1jA:
undetectable		 5csyB-4s1jA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 4s1j PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Leishmania
donovani) 		5 / 12 GLY A 131
ILE A 101
ASN A 124
PHE A  59
LEU A 120
 None
 1.12A 5fa8A-4s1jA:
undetectable		 5fa8A-4s1jA:
22.75