SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4s1n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 4s1n PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 8 ILE A  85
LEU A  91
ASN A 100
VAL A 133
 None
None
CL  A 201 ( 4.1A)
None
 0.58A 3dcjB-4s1nA:
26.5		 3dcjB-4s1nA:
35.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 4s1n PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 8 LEU A  91
ASN A 100
VAL A 133
GLY A 136
 None
CL  A 201 ( 4.1A)
None
None
 0.65A 3dcjB-4s1nA:
26.5		 3dcjB-4s1nA:
35.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4s1n PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Streptococcus
pneumoniae) 		3 / 3 SER A  13
GLN A  16
PHE A  15
 CL  A 202 (-4.1A)
None
None
 0.80A 3g4lC-4s1nA:
undetectable		 3g4lC-4s1nA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_2
(TYROSINE-PROTEIN
KINASE ABL2)		 4s1n PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 5 VAL A 146
ILE A 130
TYR A  82
MET A  83
 None
 1.29A 3gvuA-4s1nA:
undetectable		 3gvuA-4s1nA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4s1n PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A 118
SER A 126
ILE A 163
ASP A 157
PHE A 159
 None
 0.98A 3k2hA-4s1nA:
3.0		 3k2hA-4s1nA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4s1n PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A 118
SER A 126
ILE A 163
ASP A 157
PHE A 159
 None
 0.97A 3k2hB-4s1nA:
3.0		 3k2hB-4s1nA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4s1n PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A 118
SER A 126
ILE A 163
ASP A 157
PHE A 159
 None
 0.95A 3nrrA-4s1nA:
3.1		 3nrrA-4s1nA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4s1n PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A 118
SER A 126
ILE A 163
ASP A 157
PHE A 159
 None
 0.94A 3nrrB-4s1nA:
2.9		 3nrrB-4s1nA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 4s1n PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 8 GLU A  62
TYR A  82
LEU A  79
PHE A   7
 None
 1.16A 3rqwC-4s1nA:
undetectable
3rqwD-4s1nA:
undetectable		 3rqwC-4s1nA:
19.88
3rqwD-4s1nA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 4s1n PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Streptococcus
pneumoniae) 		5 / 12 GLY A  12
ASN A 100
THR A 129
TYR A 168
VAL A 175
 CL  A 202 (-3.7A)
CL  A 201 ( 4.1A)
None
None
None
 1.16A 5d0yA-4s1nA:
undetectable		 5d0yA-4s1nA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 4s1n PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Streptococcus
pneumoniae) 		5 / 12 ILE A  18
PHE A   7
GLY A  12
ILE A  98
LEU A  69
 None
None
CL  A 202 (-3.7A)
None
None
 0.91A 5e72A-4s1nA:
undetectable		 5e72A-4s1nA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_D_BRLD501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4s1n PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Streptococcus
pneumoniae) 		5 / 12 PHE A   7
GLY A  81
LEU A  37
LEU A  65
TYR A  61
 None
CL  A 202 ( 4.8A)
None
None
None
 1.22A 5ji0D-4s1nA:
undetectable		 5ji0D-4s1nA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_2
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 4s1n PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Streptococcus
pneumoniae) 		3 / 3 VAL A   6
LYS A   2
MET A   1
 None
 1.05A 5nknA-4s1nA:
undetectable		 5nknA-4s1nA:
15.22