SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4s1t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 4s1t URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(Human
coronavirus
229E) 		3 / 3 ARG A 125
TYR A  81
LYS A  82
 None
 0.97A 1uujB-4s1tA:
undetectable		 1uujB-4s1tA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4s1t URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(Human
coronavirus
229E) 		6 / 9 PHE A 233
VAL A 237
LEU A 251
PHE A 222
MET A 210
SER A 208
 None
 1.30A 1wrkA-4s1tA:
undetectable
1wrkB-4s1tA:
undetectable		 1wrkA-4s1tA:
14.45
1wrkB-4s1tA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4s1t URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(Human
coronavirus
229E) 		5 / 9 PHE A 233
VAL A 237
PHE A 222
MET A 210
LEU A 308
 None
 1.23A 1wrkA-4s1tA:
undetectable
1wrkB-4s1tA:
undetectable		 1wrkA-4s1tA:
14.45
1wrkB-4s1tA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4s1t URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(Human
coronavirus
229E) 		4 / 5 PHE A 233
LEU A 251
PHE A 222
MET A 210
 None
 1.24A 1wrkB-4s1tA:
undetectable		 1wrkB-4s1tA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4s1t URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(Human
coronavirus
229E) 		5 / 7 PHE A 233
LEU A 251
PHE A 222
MET A 210
SER A 208
 None
 1.32A 1wrlA-4s1tA:
undetectable
1wrlB-4s1tA:
undetectable		 1wrlA-4s1tA:
14.45
1wrlB-4s1tA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4s1t URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(Human
coronavirus
229E) 		6 / 6 PHE A 233
VAL A 237
LEU A 251
PHE A 222
MET A 210
SER A 208
 None
 1.26A 1wrlB-4s1tA:
undetectable		 1wrlB-4s1tA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 4s1t URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(Human
coronavirus
229E) 		4 / 7 SER A 242
ASP A 240
ARG A 257
LEU A 258
 None
 0.98A 2cdqB-4s1tA:
undetectable		 2cdqB-4s1tA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4s1t URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(Human
coronavirus
229E) 		5 / 12 ILE A 150
SER A 273
ALA A 272
LEU A  94
ILE A  71
 None
 1.18A 2xkwB-4s1tA:
undetectable		 2xkwB-4s1tA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_C_PXLC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4s1t URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(Human
coronavirus
229E) 		4 / 8 GLY A 248
ASP A 240
GLY A 239
VAL A 282
 PO4  A 401 (-3.4A)
None
None
None
 0.78A 4c5nC-4s1tA:
undetectable		 4c5nC-4s1tA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 4s1t URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(Human
coronavirus
229E) 		4 / 8 ASP A 274
SER A  70
CYH A 114
GLY A  76
 None
 0.90A 4fo4A-4s1tA:
undetectable		 4fo4A-4s1tA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 4s1t URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(Human
coronavirus
229E) 		3 / 3 SER A 273
ALA A 271
VAL A 270
 None
 0.56A 4o2bA-4s1tA:
undetectable		 4o2bA-4s1tA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 4s1t URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(Human
coronavirus
229E) 		5 / 10 GLY A 247
GLY A 239
LEU A 249
LEU A 264
TYR A 284
 PO4  A 401 ( 4.2A)
None
None
None
None
 1.32A 5hwkA-4s1tA:
undetectable		 5hwkA-4s1tA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 4s1t URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(Human
coronavirus
229E) 		5 / 10 GLY A 247
GLY A 239
LEU A 249
LEU A 264
TYR A 284
 PO4  A 401 ( 4.2A)
None
None
None
None
 1.31A 5hwkB-4s1tA:
undetectable		 5hwkB-4s1tA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 4s1t URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(Human
coronavirus
229E) 		4 / 8 ILE A 253
LEU A 228
ILE A 223
LEU A 300
 None
 0.87A 5ieoA-4s1tA:
undetectable		 5ieoA-4s1tA:
18.27