SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4s1w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 4s1w GLUTAMINE--FRUCTOSE-
6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]
(Staphylococcus
aureus) 		5 / 12 LEU A 433
ALA A 405
ALA A 408
LEU A 278
GLN A 272
 None
 1.35A 1rbpA-4s1wA:
undetectable		 1rbpA-4s1wA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4s1w GLUTAMINE--FRUCTOSE-
6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]
(Staphylococcus
aureus) 		5 / 12 GLU A 532
GLY A 528
ASP A 553
ASN A 529
ALA A 517
 None
 1.23A 2bm9B-4s1wA:
2.3		 2bm9B-4s1wA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 4s1w GLUTAMINE--FRUCTOSE-
6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]
(Staphylococcus
aureus) 		5 / 12 ILE A 371
LEU A 389
ILE A 345
ILE A 267
VAL A 417
 None
 1.11A 2ygnA-4s1wA:
undetectable		 2ygnA-4s1wA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_B_LOCB502_1
(TUBULIN BETA CHAIN)		 4s1w GLUTAMINE--FRUCTOSE-
6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]
(Staphylococcus
aureus) 		5 / 12 LYS A 435
THR A 404
ALA A 408
ILE A 412
ILE A 267
 None
 1.09A 3ut5B-4s1wA:
5.5		 3ut5B-4s1wA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 4s1w GLUTAMINE--FRUCTOSE-
6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]
(Staphylococcus
aureus) 		5 / 12 GLY A 479
ILE A 489
ALA A 491
ALA A 581
ARG A 584
 None
 1.21A 4kicA-4s1wA:
3.5		 4kicA-4s1wA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 4s1w GLUTAMINE--FRUCTOSE-
6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]
(Staphylococcus
aureus) 		5 / 12 LEU A 430
ALA A 418
ILE A 267
LEU A 564
LEU A 567
 None
 1.17A 4l9qB-4s1wA:
undetectable		 4l9qB-4s1wA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 4s1w GLUTAMINE--FRUCTOSE-
6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]
(Staphylococcus
aureus) 		4 / 7 THR A 372
THR A 351
ALA A 352
THR A 378
 None
 0.89A 4qw0K-4s1wA:
undetectable		 4qw0K-4s1wA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 4s1w GLUTAMINE--FRUCTOSE-
6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]
(Staphylococcus
aureus) 		4 / 7 THR A 372
THR A 351
ALA A 352
THR A 378
 None
 0.89A 4qw0Y-4s1wA:
undetectable		 4qw0Y-4s1wA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 4s1w GLUTAMINE--FRUCTOSE-
6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]
(Staphylococcus
aureus) 		4 / 7 THR A 404
GLN A 347
ALA A 408
ILE A 267
 None
 0.91A 4txnA-4s1wA:
3.5		 4txnA-4s1wA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 4s1w GLUTAMINE--FRUCTOSE-
6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]
(Staphylococcus
aureus) 		4 / 7 THR A 404
GLN A 347
ALA A 408
ILE A 267
 None
 0.87A 4txnB-4s1wA:
3.9		 4txnB-4s1wA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 4s1w GLUTAMINE--FRUCTOSE-
6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]
(Staphylococcus
aureus) 		4 / 7 THR A 404
GLN A 347
ALA A 408
ILE A 267
 None
 0.84A 4txnC-4s1wA:
3.9		 4txnC-4s1wA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 4s1w GLUTAMINE--FRUCTOSE-
6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]
(Staphylococcus
aureus) 		4 / 7 THR A 404
GLN A 347
ALA A 408
ILE A 267
 None
 0.84A 4txnD-4s1wA:
3.4		 4txnD-4s1wA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 4s1w GLUTAMINE--FRUCTOSE-
6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]
(Staphylococcus
aureus) 		3 / 3 SER A 377
GLU A 394
GLU A 478
 None
 0.70A 4ymgB-4s1wA:
2.5		 4ymgB-4s1wA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 4s1w GLUTAMINE--FRUCTOSE-
6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]
(Staphylococcus
aureus) 		5 / 9 ILE A 280
VAL A 319
LEU A 313
ILE A 294
LEU A 278
 None
 1.26A 5iepA-4s1wA:
undetectable		 5iepA-4s1wA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4s1w GLUTAMINE--FRUCTOSE-
6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]
(Staphylococcus
aureus) 		6 / 10 ILE A 345
VAL A 288
ALA A 291
LEU A 369
LEU A 410
LEU A 413
 None
 1.10A 6f6nA-4s1wA:
undetectable
6f6nB-4s1wA:
undetectable		 6f6nA-4s1wA:
10.32
6f6nB-4s1wA:
13.40