SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4s2m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 4s2m BETA-LACTAMASE
(Enterobacter
cloacae) 		4 / 7 ILE A 130
PHE A 156
ILE A 162
PHE A  72
 None
 1.15A 2qb4A-4s2mA:
undetectable		 2qb4A-4s2mA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_B_QELB1_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 4s2m BETA-LACTAMASE
(Enterobacter
cloacae) 		5 / 11 ALA A 166
GLN A 169
ILE A 170
PHE A 234
THR A 213
 None
 1.49A 3qelA-4s2mA:
undetectable
3qelB-4s2mA:
undetectable		 3qelA-4s2mA:
23.00
3qelB-4s2mA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_2
(GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 4s2m BETA-LACTAMASE
(Enterobacter
cloacae) 		5 / 9 ALA A 166
GLN A 169
ILE A 170
PHE A 234
THR A 213
 None
 1.45A 3qelD-4s2mA:
undetectable		 3qelD-4s2mA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_2
(GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 4s2m BETA-LACTAMASE
(Enterobacter
cloacae) 		5 / 9 ALA A 166
GLN A 169
ILE A 170
THR A 213
PRO A  68
 None
 1.44A 3qelD-4s2mA:
undetectable		 3qelD-4s2mA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 4s2m BETA-LACTAMASE
(Enterobacter
cloacae) 		5 / 12 LEU A  46
THR A  71
ILE A 204
PHE A 235
VAL A  43
 None
 1.20A 5dlvB-4s2mA:
undetectable		 5dlvB-4s2mA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4s2m BETA-LACTAMASE
(Enterobacter
cloacae) 		4 / 5 LEU A  81
ARG A 134
ILE A  79
ILE A 130
 None
 1.09A 5dzk4-4s2mA:
undetectable
5dzkg-4s2mA:
undetectable
5dzkm-4s2mA:
undetectable
5dzkn-4s2mA:
undetectable		 5dzk4-4s2mA:
1.74
5dzkg-4s2mA:
20.72
5dzkm-4s2mA:
20.80
5dzkn-4s2mA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4s2m BETA-LACTAMASE
(Enterobacter
cloacae) 		4 / 4 ILE A  79
ILE A 130
ARG A 134
LEU A  81
 None
 1.25A 5dzkh-4s2mA:
undetectable
5dzkn-4s2mA:
undetectable
5dzkv-4s2mA:
undetectable		 5dzkh-4s2mA:
20.80
5dzkn-4s2mA:
20.80
5dzkv-4s2mA:
1.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4s2m BETA-LACTAMASE
(Enterobacter
cloacae) 		5 / 9 GLY A  84
LEU A  83
LEU A 181
ILE A 130
PHE A 172
 None
 0.97A 5vkqC-4s2mA:
undetectable
5vkqD-4s2mA:
undetectable		 5vkqC-4s2mA:
8.93
5vkqD-4s2mA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4s2m BETA-LACTAMASE
(Enterobacter
cloacae) 		5 / 9 GLY A  84
LEU A 181
ILE A 130
PHE A 172
ILE A  74
 None
 0.99A 5vkqC-4s2mA:
undetectable
5vkqD-4s2mA:
undetectable		 5vkqC-4s2mA:
8.93
5vkqD-4s2mA:
8.93