SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4s2t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)
4s2t PROTEIN APP-1
(Caenorhabditis
elegans)
4 / 5 THR P 422
THR P 423
GLU P 536
HIS P 496
None
None
ZN  P 701 (-2.4A)
None
1.39A 1d4fB-4s2tP:
undetectable
1d4fB-4s2tP:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)
4s2t PROTEIN APP-1
(Caenorhabditis
elegans)
3 / 3 ARG P 427
THR P 423
VAL P 425
None
0.93A 1hxbA-4s2tP:
undetectable
1hxbA-4s2tP:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA8_0
(MINI-GRAMICIDIN A)
4s2t PROTEIN APP-1
(Caenorhabditis
elegans)
4 / 5 VAL P 230
TRP P 268
ALA P 199
TRP P 272
None
1.33A 1kqeA-4s2tP:
undetectable
1kqeE-4s2tP:
undetectable
1kqeA-4s2tP:
3.22
1kqeE-4s2tP:
3.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)
4s2t PROTEIN APP-1
(Caenorhabditis
elegans)
5 / 12 LEU P 452
GLY P 484
GLY P 486
GLY P 488
TYR P 539
None
1.11A 1y4lA-4s2tP:
undetectable
1y4lA-4s2tP:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)
4s2t PROTEIN APP-1
(Caenorhabditis
elegans)
4 / 4 LEU P 187
SER P 309
LEU P 228
LEU P 210
SO4  P 703 (-3.8A)
None
None
None
1.00A 1yajA-4s2tP:
undetectable
1yajA-4s2tP:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)
4s2t PROTEIN APP-1
(Caenorhabditis
elegans)
4 / 8 ASP P 472
TRP P 475
LYS P 476
GLY P 478
None
0.83A 2aouA-4s2tP:
undetectable
2aouA-4s2tP:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)
4s2t PROTEIN APP-1
(Caenorhabditis
elegans)
5 / 12 ILE P 502
LEU P 513
SER P 558
ARG P 588
ILE P 521
None
None
SO4  P 704 (-4.9A)
SO4  P 704 (-4.0A)
None
1.30A 2e7fA-4s2tP:
undetectable
2e7fA-4s2tP:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)
4s2t PROTEIN APP-1
(Caenorhabditis
elegans)
5 / 12 ILE P 502
LEU P 513
SER P 558
ARG P 588
ILE P 521
None
None
SO4  P 704 (-4.9A)
SO4  P 704 (-4.0A)
None
1.30A 2e7fB-4s2tP:
undetectable
2e7fB-4s2tP:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)
4s2t PROTEIN APP-1
(Caenorhabditis
elegans)
5 / 11 LEU P 573
LEU P 574
ILE P 439
PRO P 434
LEU P 474
None
1.29A 2ft9A-4s2tP:
undetectable
2ft9A-4s2tP:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)
4s2t PROTEIN APP-1
(Caenorhabditis
elegans)
5 / 12 ILE P 502
LEU P 513
SER P 558
ARG P 588
ILE P 521
None
None
SO4  P 704 (-4.9A)
SO4  P 704 (-4.0A)
None
1.30A 2ogyA-4s2tP:
undetectable
2ogyA-4s2tP:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)
4s2t PROTEIN APP-1
(Caenorhabditis
elegans)
5 / 12 ILE P 502
LEU P 513
SER P 558
ARG P 588
ILE P 521
None
None
SO4  P 704 (-4.9A)
SO4  P 704 (-4.0A)
None
1.31A 2ogyB-4s2tP:
undetectable
2ogyB-4s2tP:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)
4s2t PROTEIN APP-1
(Caenorhabditis
elegans)
3 / 3 ARG P 427
THR P 423
VAL P 425
None
0.94A 2q64A-4s2tP:
undetectable
2q64A-4s2tP:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)
4s2t PROTEIN APP-1
(Caenorhabditis
elegans)
3 / 3 ARG P 427
THR P 423
VAL P 425
None
0.91A 2qakA-4s2tP:
undetectable
2qakA-4s2tP:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)
4s2t PROTEIN APP-1
(Caenorhabditis
elegans)
4 / 8 TYR P 531
ILE P 533
LEU P 479
LEU P 477
None
0.84A 2vctA-4s2tP:
undetectable
2vctA-4s2tP:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)
4s2t PROTEIN APP-1
(Caenorhabditis
elegans)
4 / 8 TYR P 531
ILE P 533
LEU P 479
LEU P 477
None
0.87A 2vctB-4s2tP:
undetectable
2vctB-4s2tP:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)
4s2t PROTEIN APP-1
(Caenorhabditis
elegans)
5 / 12 ILE P 218
SER P  41
SER P  35
LEU P 125
TYR P 262
None
1.15A 3k2hB-4s2tP:
undetectable
3k2hB-4s2tP:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)
4s2t PROTEIN APP-1
(Caenorhabditis
elegans)
4 / 8 ASN P 433
THR P 432
GLN P 565
SER P 567
None
1.03A 3kp6A-4s2tP:
undetectable
3kp6A-4s2tP:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P73_A_ACTA275_0
(MHC RFP-Y CLASS I
ALPHA CHAIN)
4s2t PROTEIN APP-1
(Caenorhabditis
elegans)
3 / 3 ILE P 235
VAL P 184
ARG P 188
None
0.73A 3p73A-4s2tP:
undetectable
3p73A-4s2tP:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_C_ACRC701_1
(ALPHA-GLUCOSIDASE)
4s2t PROTEIN APP-1
(Caenorhabditis
elegans)
5 / 12 ILE P 218
ASP P 122
ASP P 154
ARG P 160
ASP P  48
None
1.38A 3phaC-4s2tP:
undetectable
3phaC-4s2tP:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)
4s2t PROTEIN APP-1
(Caenorhabditis
elegans)
5 / 11 GLN P  82
PHE P  57
TYR P  43
GLY P  59
GLY P  56
SO4  P 705 (-3.9A)
None
None
None
None
1.18A 3sufC-4s2tP:
undetectable
3sufC-4s2tP:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)
4s2t PROTEIN APP-1
(Caenorhabditis
elegans)
4 / 5 SER P 558
THR P 560
GLU P 540
ASP P 320
SO4  P 704 (-4.9A)
None
None
None
1.44A 3tm4B-4s2tP:
undetectable
3tm4B-4s2tP:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)
4s2t PROTEIN APP-1
(Caenorhabditis
elegans)
5 / 12 LEU P 204
ILE P 239
TYR P 225
ILE P 218
LEU P 163
None
1.19A 3vw1B-4s2tP:
undetectable
3vw1B-4s2tP:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
4s2t PROTEIN APP-1
(Caenorhabditis
elegans)
5 / 12 ILE P 269
TRP P 268
VAL P 184
LEU P 187
VAL P 311
None
None
None
SO4  P 703 (-3.8A)
SO4  P 703 (-4.6A)
1.01A 3w68C-4s2tP:
undetectable
3w68C-4s2tP:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)
4s2t PROTEIN APP-1
(Caenorhabditis
elegans)
4 / 6 THR P 124
TYR P 266
HIS P  39
TYR P 227
None
1.48A 4df2A-4s2tP:
undetectable
4df2A-4s2tP:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)
4s2t PROTEIN APP-1
(Caenorhabditis
elegans)
4 / 6 TRP P 108
THR P 134
VAL P  66
SER P 126
None
1.03A 4iaqA-4s2tP:
undetectable
4iaqA-4s2tP:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)
4s2t PROTEIN APP-1
(Caenorhabditis
elegans)
5 / 12 ILE P 119
PRO P 145
LEU P 109
VAL P  65
THR P  36
None
0.90A 4kfjB-4s2tP:
undetectable
4kfjB-4s2tP:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)
4s2t PROTEIN APP-1
(Caenorhabditis
elegans)
3 / 3 GLY P 524
GLU P 522
THR P 485
None
ZN  P 702 ( 2.6A)
None
0.59A 4kouA-4s2tP:
undetectable
4kouA-4s2tP:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)
4s2t PROTEIN APP-1
(Caenorhabditis
elegans)
3 / 3 ASP P  68
TRP P  74
SER P 117
None
0.99A 4lrhA-4s2tP:
undetectable
4lrhA-4s2tP:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)
4s2t PROTEIN APP-1
(Caenorhabditis
elegans)
5 / 12 PHE P 556
LEU P 559
GLY P 448
THR P 560
THR P 470
None
1.35A 4mubA-4s2tP:
undetectable
4mubA-4s2tP:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)
4s2t PROTEIN APP-1
(Caenorhabditis
elegans)
4 / 6 ASP P 122
VAL P 153
ASP P 154
ALA P  38
None
1.17A 4nedA-4s2tP:
undetectable
4nedA-4s2tP:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)
4s2t PROTEIN APP-1
(Caenorhabditis
elegans)
5 / 12 ILE P 521
TYR P 585
VAL P 589
SER P 558
LEU P 446
None
None
None
SO4  P 704 (-4.9A)
None
1.50A 4qztA-4s2tP:
undetectable
4qztA-4s2tP:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)
4s2t PROTEIN APP-1
(Caenorhabditis
elegans)
4 / 4 LEU P 474
ILE P 533
HIS P 441
VAL P 445
None
1.17A 4xyzA-4s2tP:
undetectable
4xyzA-4s2tP:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)
4s2t PROTEIN APP-1
(Caenorhabditis
elegans)
3 / 3 LEU P 331
ARG P 332
ARG P 600
None
0.78A 4yiaB-4s2tP:
undetectable
4yiaB-4s2tP:
4.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)
4s2t PROTEIN APP-1
(Caenorhabditis
elegans)
5 / 11 LEU P 446
VAL P 445
ASN P 442
PHE P 438
GLY P 532
None
1.00A 4zbqA-4s2tP:
undetectable
4zbqA-4s2tP:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
4s2t PROTEIN APP-1
(Caenorhabditis
elegans)
4 / 5 VAL P 384
TYR P  43
ILE P 218
THR P 422
None
1.29A 4ze1A-4s2tP:
undetectable
4ze1A-4s2tP:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)
4s2t PROTEIN APP-1
(Caenorhabditis
elegans)
5 / 12 GLY P 120
ASP P 154
VAL P 153
VAL P  65
LEU P  33
None
0.96A 5kocA-4s2tP:
undetectable
5kocA-4s2tP:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)
4s2t PROTEIN APP-1
(Caenorhabditis
elegans)
4 / 7 GLY P 486
HIS P 487
ASP P 424
HIS P 392
None
ZN  P 702 ( 3.7A)
ZN  P 701 (-2.4A)
None
0.75A 5nnwD-4s2tP:
undetectable
5nnwD-4s2tP:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)
4s2t PROTEIN APP-1
(Caenorhabditis
elegans)
4 / 7 GLY P 486
HIS P 487
ASP P 424
HIS P 392
None
ZN  P 702 ( 3.7A)
ZN  P 701 (-2.4A)
None
0.78A 5no9D-4s2tP:
undetectable
5no9D-4s2tP:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)
4s2t PROTEIN APP-1
(Caenorhabditis
elegans)
4 / 7 ASN P 212
ARG P 214
ILE P 213
GLY P 215
None
0.84A 5nzyA-4s2tP:
undetectable
5nzyA-4s2tP:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)
4s2t PROTEIN APP-1
(Caenorhabditis
elegans)
5 / 12 LEU P 287
VAL P 285
ALA P 231
TRP P 268
ALA P 198
None
0.75A 5tzoB-4s2tP:
undetectable
5tzoB-4s2tP:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
4s2t PROTEIN APP-1
(Caenorhabditis
elegans)
5 / 10 GLY P 532
LEU P 359
ILE P 381
LEU P 412
THR P 428
None
0.95A 5vm8B-4s2tP:
undetectable
5vm8B-4s2tP:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)
4s2t PROTEIN APP-1
(Caenorhabditis
elegans)
5 / 12 HIS P 483
VAL P 562
ARG P 534
VAL P 425
ASP P 413
None
None
None
None
ZN  P 701 ( 2.2A)
1.40A 6bxlB-4s2tP:
undetectable
6bxlB-4s2tP:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_0
(ADENOSYLHOMOCYSTEINA
SE)
4s2t PROTEIN APP-1
(Caenorhabditis
elegans)
5 / 12 HIS P 483
ASP P 424
HIS P 392
GLY P 486
HIS P 487
None
ZN  P 701 (-2.4A)
None
None
ZN  P 702 ( 3.7A)
1.49A 6exiA-4s2tP:
undetectable
6exiA-4s2tP:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_A_ACTA403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)
4s2t PROTEIN APP-1
(Caenorhabditis
elegans)
3 / 3 TYR P 418
ASP P 371
GLN P 370
None
0.94A 6g1pA-4s2tP:
undetectable
6g1pA-4s2tP:
20.34