SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4s2u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1428_0
(FPRA)		 4s2u RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Escherichia
coli) 		4 / 7 PHE A  92
ALA A 114
PHE A 139
PHE A 138
 None
 1.26A 1lquA-4s2uA:
undetectable		 1lquA-4s2uA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4s2u RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Escherichia
coli) 		4 / 5 ASP A 220
LEU A 152
ALA A 246
LEU A 229
 None
 1.01A 1nh8A-4s2uA:
undetectable		 1nh8A-4s2uA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		 4s2u RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Escherichia
coli) 		3 / 3 SER A 149
ASP A 129
ASN A 145
 None
 1.01A 3lsfB-4s2uA:
undetectable
3lsfE-4s2uA:
undetectable		 3lsfB-4s2uA:
23.51
3lsfE-4s2uA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 4s2u RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Escherichia
coli) 		5 / 12 ILE A  85
ILE A  89
PRO A  90
LEU A  70
VAL A 122
 None
 0.90A 4kfjB-4s2uA:
undetectable		 4kfjB-4s2uA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 4s2u RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Escherichia
coli) 		3 / 3 TYR A  91
THR A 127
THR A  59
 None
 0.81A 5aoxB-4s2uA:
undetectable		 5aoxB-4s2uA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_F_ACTF1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 4s2u RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Escherichia
coli) 		3 / 3 TYR A  91
THR A 127
THR A  59
 None
 0.82A 5aoxE-4s2uA:
undetectable		 5aoxE-4s2uA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4s2u RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Escherichia
coli) 		5 / 12 VAL A 166
ASP A 155
LEU A 152
PRO A 169
LEU A 229
 None
 1.07A 6b0iB-4s2uA:
6.0		 6b0iB-4s2uA:
15.20