SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4s3k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4s3k SPORE GERMINATION
PROTEIN YAAH
(Bacillus
megaterium) 		4 / 7 ILE A 271
GLY A 272
PRO A 280
ASN A 276
 None
None
None
SO4  A 501 (-3.9A)
 0.98A 1oniG-4s3kA:
undetectable
1oniI-4s3kA:
1.1		 1oniG-4s3kA:
17.32
1oniI-4s3kA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RK3_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 4s3k SPORE GERMINATION
PROTEIN YAAH
(Bacillus
megaterium) 		4 / 4 LEU A 323
ILE A 318
ARG A 402
TYR A 283
 None
None
SO4  A 501 (-2.9A)
None
 1.47A 1rk3A-4s3kA:
undetectable		 1rk3A-4s3kA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2001_1
(SERUM ALBUMIN)		 4s3k SPORE GERMINATION
PROTEIN YAAH
(Bacillus
megaterium) 		5 / 10 ALA A 230
PHE A 231
ALA A 235
ARG A 238
LEU A 239
 None
 0.66A 2bxqA-4s3kA:
undetectable		 2bxqA-4s3kA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 4s3k SPORE GERMINATION
PROTEIN YAAH
(Bacillus
megaterium) 		5 / 12 PHE A 277
ALA A 405
GLY A 157
LEU A 156
LEU A 153
 None
 1.09A 2hw2A-4s3kA:
undetectable		 2hw2A-4s3kA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_2
(AAC(6')-IB)		 4s3k SPORE GERMINATION
PROTEIN YAAH
(Bacillus
megaterium) 		3 / 3 TRP A 417
GLN A 345
TRP A 407
 None
 1.38A 2vqyA-4s3kA:
undetectable		 2vqyA-4s3kA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 4s3k SPORE GERMINATION
PROTEIN YAAH
(Bacillus
megaterium) 		4 / 5 LEU A 323
ILE A 318
ARG A 402
TYR A 283
 None
None
SO4  A 501 (-2.9A)
None
 1.40A 2zlcA-4s3kA:
undetectable		 2zlcA-4s3kA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4s3k SPORE GERMINATION
PROTEIN YAAH
(Bacillus
megaterium) 		5 / 12 PHE A 140
GLY A 136
ILE A 125
THR A 121
LEU A 156
 None
 0.90A 3iv6A-4s3kA:
undetectable		 3iv6A-4s3kA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4s3k SPORE GERMINATION
PROTEIN YAAH
(Bacillus
megaterium) 		5 / 12 ALA A  29
LEU A  32
ILE A  15
SER A  11
LEU A  38
 None
 1.13A 3k2hB-4s3kA:
undetectable		 3k2hB-4s3kA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4s3k SPORE GERMINATION
PROTEIN YAAH
(Bacillus
megaterium) 		4 / 6 GLN A  18
TYR A   4
GLN A  42
SER A  14
 None
SO4  A 502 ( 4.9A)
None
None
 0.87A 3peoG-4s3kA:
undetectable		 3peoG-4s3kA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 4s3k SPORE GERMINATION
PROTEIN YAAH
(Bacillus
megaterium) 		5 / 12 TRP A 407
GLY A 136
GLY A 108
PHE A 167
ALA A 138
 None
 1.13A 4a6dA-4s3kA:
undetectable		 4a6dA-4s3kA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 4s3k SPORE GERMINATION
PROTEIN YAAH
(Bacillus
megaterium) 		5 / 12 TRP A 407
GLY A 136
GLY A 108
PHE A 167
ALA A 138
 None
 1.07A 4a6eA-4s3kA:
undetectable		 4a6eA-4s3kA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A81_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 4s3k SPORE GERMINATION
PROTEIN YAAH
(Bacillus
megaterium) 		5 / 12 ILE A 420
GLY A 104
ILE A 318
VAL A 279
ASN A 322
 None
 1.23A 4a81A-4s3kA:
undetectable		 4a81A-4s3kA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 4s3k SPORE GERMINATION
PROTEIN YAAH
(Bacillus
megaterium) 		3 / 3 GLU A 311
TYR A 307
SER A 255
 None
 0.94A 4at0A-4s3kA:
undetectable		 4at0A-4s3kA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4s3k SPORE GERMINATION
PROTEIN YAAH
(Bacillus
megaterium) 		4 / 7 LEU A 411
PRO A 367
SER A 388
VAL A 381
 None
 0.99A 4klrA-4s3kA:
undetectable		 4klrA-4s3kA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4s3k SPORE GERMINATION
PROTEIN YAAH
(Bacillus
megaterium) 		3 / 3 LEU A 401
ARG A 402
MET A 246
 None
SO4  A 501 (-2.9A)
None
 0.87A 4m11C-4s3kA:
undetectable		 4m11C-4s3kA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4s3k SPORE GERMINATION
PROTEIN YAAH
(Bacillus
megaterium) 		4 / 7 ALA A 230
ARG A 185
GLY A 184
GLU A 182
 None
 0.96A 5btdA-4s3kA:
undetectable
5btdB-4s3kA:
1.7
5btdC-4s3kA:
undetectable		 5btdA-4s3kA:
22.14
5btdB-4s3kA:
23.40
5btdC-4s3kA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4s3k SPORE GERMINATION
PROTEIN YAAH
(Bacillus
megaterium) 		4 / 7 ALA A 230
ARG A 185
GLY A 184
GLU A 182
 None
 1.00A 5btdA-4s3kA:
undetectable
5btdC-4s3kA:
undetectable
5btdD-4s3kA:
1.9		 5btdA-4s3kA:
22.14
5btdC-4s3kA:
22.14
5btdD-4s3kA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4s3k SPORE GERMINATION
PROTEIN YAAH
(Bacillus
megaterium) 		4 / 6 ALA A 230
ARG A 185
GLY A 184
GLU A 182
 None
 0.92A 5btgA-4s3kA:
undetectable
5btgB-4s3kA:
1.7
5btgC-4s3kA:
undetectable		 5btgA-4s3kA:
22.14
5btgB-4s3kA:
23.40
5btgC-4s3kA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4s3k SPORE GERMINATION
PROTEIN YAAH
(Bacillus
megaterium) 		4 / 7 ALA A 230
ARG A 185
GLY A 184
GLU A 182
 None
 0.89A 5btgA-4s3kA:
undetectable
5btgC-4s3kA:
undetectable
5btgD-4s3kA:
undetectable		 5btgA-4s3kA:
22.14
5btgC-4s3kA:
22.14
5btgD-4s3kA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 4s3k SPORE GERMINATION
PROTEIN YAAH
(Bacillus
megaterium) 		5 / 12 ILE A 396
GLY A 104
PHE A 424
TYR A 134
ILE A 318
 None
 1.31A 5j7wC-4s3kA:
undetectable		 5j7wC-4s3kA:
20.09