SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4s3l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4s3l MAJOR PILIN PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 SER A 337
PHE A 305
ILE A 244
ASN A 371
PHE A 261
 None
 1.37A 2vdyA-4s3lA:
undetectable		 2vdyA-4s3lA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4s3l MAJOR PILIN PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 SER A 337
PHE A 305
ILE A 244
ASN A 371
PHE A 261
 None
 1.36A 2vdyB-4s3lA:
undetectable		 2vdyB-4s3lA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4s3l MAJOR PILIN PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 ILE A  64
LEU A 214
PHE A 215
THR A  86
 None
 1.11A 2zxwN-4s3lA:
undetectable
2zxwW-4s3lA:
undetectable		 2zxwN-4s3lA:
20.38
2zxwW-4s3lA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4s3l MAJOR PILIN PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 SER A 337
PHE A 305
ILE A 244
ASN A 371
PHE A 261
 None
 1.37A 4c49B-4s3lA:
undetectable		 4c49B-4s3lA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4s3l MAJOR PILIN PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 SER A 337
PHE A 305
ILE A 244
ASN A 371
PHE A 261
 None
 1.35A 4c49C-4s3lA:
undetectable		 4c49C-4s3lA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4s3l MAJOR PILIN PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 SER A 337
PHE A 305
ILE A 244
ASN A 371
PHE A 261
 None
 1.45A 4c49D-4s3lA:
undetectable		 4c49D-4s3lA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 4s3l MAJOR PILIN PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 ASP A 120
GLY A 321
PRO A 277
THR A 276
 None
 0.99A 4l1aB-4s3lA:
undetectable		 4l1aB-4s3lA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 4s3l MAJOR PILIN PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 ASN A  65
THR A  67
ASN A 213
GLU A 208
 None
 1.28A 5uigA-4s3lA:
undetectable		 5uigA-4s3lA:
21.62