SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4s3m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 4s3m 2-DEHYDROPANTOATE
2-REDUCTASE
(Staphylococcus
aureus) 		4 / 7 TYR A  40
VAL A 126
ILE A 117
GLY A  11
 None
None
None
NAP  A 500 (-3.1A)
 0.85A 11gsA-4s3mA:
undetectable		 11gsA-4s3mA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		 4s3m 2-DEHYDROPANTOATE
2-REDUCTASE
(Staphylococcus
aureus) 		5 / 10 TYR A  40
VAL A 126
VAL A  53
ILE A 117
GLY A  11
 None
None
None
None
NAP  A 500 (-3.1A)
 0.92A 13gsA-4s3mA:
undetectable		 13gsA-4s3mA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 4s3m 2-DEHYDROPANTOATE
2-REDUCTASE
(Staphylococcus
aureus) 		5 / 12 HIS A  81
ILE A   8
ILE A  31
ALA A  86
TYR A  84
 None
 1.48A 1ki7B-4s3mA:
undetectable		 1ki7B-4s3mA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_F_H4BF1005_1
(HYPOTHETICAL PROTEIN
PH0634)		 4s3m 2-DEHYDROPANTOATE
2-REDUCTASE
(Staphylococcus
aureus) 		5 / 9 ILE A  66
ASP A  64
PHE A  63
THR A  28
THR A  29
 None
 1.13A 2dttE-4s3mA:
undetectable
2dttF-4s3mA:
0.6		 2dttE-4s3mA:
17.29
2dttF-4s3mA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 4s3m 2-DEHYDROPANTOATE
2-REDUCTASE
(Staphylococcus
aureus) 		4 / 8 TYR A  40
VAL A 126
ILE A 117
GLY A  11
 None
None
None
NAP  A 500 (-3.1A)
 0.80A 2gssA-4s3mA:
undetectable		 2gssA-4s3mA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 4s3m 2-DEHYDROPANTOATE
2-REDUCTASE
(Staphylococcus
aureus) 		4 / 8 TYR A  40
VAL A 126
ILE A 117
GLY A  11
 None
None
None
NAP  A 500 (-3.1A)
 0.80A 2gssB-4s3mA:
undetectable		 2gssB-4s3mA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 4s3m 2-DEHYDROPANTOATE
2-REDUCTASE
(Staphylococcus
aureus) 		5 / 8 TYR A  40
VAL A 126
VAL A  53
ILE A 117
GLY A  11
 None
None
None
None
NAP  A 500 (-3.1A)
 0.90A 3hjoA-4s3mA:
undetectable		 3hjoA-4s3mA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 4s3m 2-DEHYDROPANTOATE
2-REDUCTASE
(Staphylococcus
aureus) 		4 / 8 VAL A 126
VAL A  53
ILE A 117
GLY A  11
 None
None
None
NAP  A 500 (-3.1A)
 0.79A 3hjoB-4s3mA:
undetectable		 3hjoB-4s3mA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 4s3m 2-DEHYDROPANTOATE
2-REDUCTASE
(Staphylococcus
aureus) 		5 / 10 TYR A  40
VAL A 126
VAL A  53
ILE A 117
GLY A  11
 None
None
None
None
NAP  A 500 (-3.1A)
 0.92A 3km6A-4s3mA:
undetectable		 3km6A-4s3mA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 4s3m 2-DEHYDROPANTOATE
2-REDUCTASE
(Staphylococcus
aureus) 		4 / 8 TYR A  40
VAL A 126
ILE A 117
GLY A  11
 None
None
None
NAP  A 500 (-3.1A)
 0.83A 3n9jA-4s3mA:
undetectable		 3n9jA-4s3mA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4s3m 2-DEHYDROPANTOATE
2-REDUCTASE
(Staphylococcus
aureus) 		5 / 9 LEU A   3
VAL A  70
ILE A   7
LEU A  91
VAL A 110
 None
NAP  A 500 ( 4.5A)
None
None
None
 1.31A 3oxzA-4s3mA:
undetectable		 3oxzA-4s3mA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)		 4s3m 2-DEHYDROPANTOATE
2-REDUCTASE
(Staphylococcus
aureus) 		5 / 12 THR A  72
GLY A 100
HIS A  73
ASN A  97
LEU A  94
 NAP  A 500 ( 4.9A)
None
None
NAP  A 500 (-3.6A)
None
 1.19A 4pooA-4s3mA:
undetectable		 4pooA-4s3mA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 4s3m 2-DEHYDROPANTOATE
2-REDUCTASE
(Staphylococcus
aureus) 		5 / 12 GLY A  14
GLY A   9
ILE A  38
ILE A  67
ALA A  18
 None
NAP  A 500 ( 3.8A)
None
None
None
 1.13A 4qtuB-4s3mA:
4.5		 4qtuB-4s3mA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4s3m 2-DEHYDROPANTOATE
2-REDUCTASE
(Staphylococcus
aureus) 		3 / 3 TYR A 272
LEU A 204
ASP A 223
 None
 0.79A 5zv2B-4s3mA:
undetectable		 5zv2B-4s3mA:
16.34