SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4s3n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_B_T44B528_1
(TRANSTHYRETIN
THR119MET VARIANT)		 4s3n 2'-5'-OLIGOADENYLATE
SYNTHASE 3
(Homo
sapiens) 		4 / 4 LYS A  28
LEU A 116
ALA A  29
LEU A 133
 None
 1.30A 1f86B-4s3nA:
undetectable		 1f86B-4s3nA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_B_MTXB352_1
(PTERIDINE REDUCTASE
1)		 4s3n 2'-5'-OLIGOADENYLATE
SYNTHASE 3
(Homo
sapiens) 		5 / 12 ARG A 331
PHE A 329
LEU A 256
LEU A 202
LEU A 248
 None
 1.49A 1p33B-4s3nA:
undetectable		 1p33B-4s3nA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_C_MTXC353_1
(PTERIDINE REDUCTASE
1)		 4s3n 2'-5'-OLIGOADENYLATE
SYNTHASE 3
(Homo
sapiens) 		5 / 12 ARG A 331
PHE A 329
LEU A 256
LEU A 202
LEU A 248
 None
 1.44A 1p33C-4s3nA:
undetectable		 1p33C-4s3nA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_1
(ESTROGEN RECEPTOR
BETA)		 4s3n 2'-5'-OLIGOADENYLATE
SYNTHASE 3
(Homo
sapiens) 		5 / 12 LEU A 232
THR A 233
ALA A 236
LEU A 345
LEU A 353
 None
 0.91A 1qknA-4s3nA:
undetectable		 1qknA-4s3nA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4s3n 2'-5'-OLIGOADENYLATE
SYNTHASE 3
(Homo
sapiens) 		3 / 3 LEU A 284
TRP A 303
TYR A 167
 None
 0.97A 3aicA-4s3nA:
undetectable		 3aicA-4s3nA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4s3n 2'-5'-OLIGOADENYLATE
SYNTHASE 3
(Homo
sapiens) 		3 / 3 LEU A 284
TRP A 303
TYR A 167
 None
 0.98A 3aicB-4s3nA:
undetectable		 3aicB-4s3nA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4s3n 2'-5'-OLIGOADENYLATE
SYNTHASE 3
(Homo
sapiens) 		3 / 3 LEU A 284
TRP A 303
TYR A 167
 None
 0.99A 3aicE-4s3nA:
undetectable		 3aicE-4s3nA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4s3n 2'-5'-OLIGOADENYLATE
SYNTHASE 3
(Homo
sapiens) 		3 / 3 LEU A 284
TRP A 303
TYR A 167
 None
 0.98A 3aicF-4s3nA:
undetectable		 3aicF-4s3nA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4s3n 2'-5'-OLIGOADENYLATE
SYNTHASE 3
(Homo
sapiens) 		3 / 3 LEU A 284
TRP A 303
TYR A 167
 None
 0.94A 3aicG-4s3nA:
undetectable		 3aicG-4s3nA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4s3n 2'-5'-OLIGOADENYLATE
SYNTHASE 3
(Homo
sapiens) 		3 / 3 LEU A 284
TRP A 303
TYR A 167
 None
 1.00A 3aicH-4s3nA:
undetectable		 3aicH-4s3nA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		 4s3n 2'-5'-OLIGOADENYLATE
SYNTHASE 3
(Homo
sapiens) 		5 / 12 LEU A 232
THR A 233
ALA A 236
LEU A 345
LEU A 353
 None
 1.06A 3hm1A-4s3nA:
undetectable		 3hm1A-4s3nA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 4s3n 2'-5'-OLIGOADENYLATE
SYNTHASE 3
(Homo
sapiens) 		4 / 8 PHE A 131
THR A 119
PRO A 121
SER A 145
 None
 0.98A 3tzfB-4s3nA:
undetectable		 3tzfB-4s3nA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA601_1
(SERUM ALBUMIN)		 4s3n 2'-5'-OLIGOADENYLATE
SYNTHASE 3
(Homo
sapiens) 		5 / 12 LEU A   3
TYR A   4
VAL A 255
LEU A 256
ARG A 253
 None
 1.41A 4po0A-4s3nA:
undetectable		 4po0A-4s3nA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 4s3n 2'-5'-OLIGOADENYLATE
SYNTHASE 3
(Homo
sapiens) 		4 / 6 PRO A 301
GLY A 178
PHE A 283
ARG A 290
 None
 1.50A 5jcnB-4s3nA:
undetectable		 5jcnB-4s3nA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA810_1
(CATALASE-PEROXIDASE)		 4s3n 2'-5'-OLIGOADENYLATE
SYNTHASE 3
(Homo
sapiens) 		4 / 6 TRP A 141
LEU A  69
PRO A  21
SER A  63
 None
 1.13A 5syjA-4s3nA:
undetectable		 5syjA-4s3nA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB810_1
(CATALASE-PEROXIDASE)		 4s3n 2'-5'-OLIGOADENYLATE
SYNTHASE 3
(Homo
sapiens) 		4 / 6 TRP A 141
LEU A  69
PRO A  21
SER A  63
 None
 1.13A 5syjB-4s3nA:
undetectable		 5syjB-4s3nA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_L_9CRL501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4s3n 2'-5'-OLIGOADENYLATE
SYNTHASE 3
(Homo
sapiens) 		6 / 12 ILE A 259
ALA A 320
ALA A 317
ARG A 253
LEU A 256
ILE A 295
 None
 1.47A 6a5zL-4s3nA:
undetectable		 6a5zL-4s3nA:
13.91